DE69222006T2 - Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten - Google Patents

Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten

Info

Publication number
DE69222006T2
DE69222006T2 DE69222006T DE69222006T DE69222006T2 DE 69222006 T2 DE69222006 T2 DE 69222006T2 DE 69222006 T DE69222006 T DE 69222006T DE 69222006 T DE69222006 T DE 69222006T DE 69222006 T2 DE69222006 T2 DE 69222006T2
Authority
DE
Germany
Prior art keywords
compositions containing
serotonin antagonists
containing histamine
multilayer compositions
multilayer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69222006T
Other languages
English (en)
Other versions
DE69222006D1 (de
Inventor
Yogendra Dandiker
Paul Derrick Huckle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919123044A external-priority patent/GB9123044D0/en
Priority claimed from GB919123026A external-priority patent/GB9123026D0/en
Priority claimed from GB929203364A external-priority patent/GB9203364D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE69222006D1 publication Critical patent/DE69222006D1/de
Publication of DE69222006T2 publication Critical patent/DE69222006T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69222006T 1991-10-30 1992-10-23 Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten Expired - Lifetime DE69222006T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919123044A GB9123044D0 (en) 1991-10-30 1991-10-30 Compositions
GB919123026A GB9123026D0 (en) 1991-10-30 1991-10-30 Compositions
GB929203364A GB9203364D0 (en) 1992-02-18 1992-02-18 Compositions

Publications (2)

Publication Number Publication Date
DE69222006D1 DE69222006D1 (de) 1997-10-09
DE69222006T2 true DE69222006T2 (de) 1998-01-22

Family

ID=27265908

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222006T Expired - Lifetime DE69222006T2 (de) 1991-10-30 1992-10-23 Mehrschichtzusammensetzungen enthaltend Histamin- oder Serotonin- Antagonisten

Country Status (21)

Country Link
US (1) US5425950A (de)
EP (1) EP0546593B1 (de)
JP (1) JPH05194188A (de)
KR (1) KR930007439A (de)
AU (1) AU666880B2 (de)
BE (1) BE1005490A3 (de)
CA (1) CA2081709C (de)
CH (1) CH685536A5 (de)
CZ (1) CZ325792A3 (de)
DE (1) DE69222006T2 (de)
ES (1) ES2106818T3 (de)
FR (1) FR2683146B1 (de)
GB (1) GB2262445B (de)
IE (1) IE922775A1 (de)
IL (1) IL103593A0 (de)
IT (1) IT1263253B (de)
LU (1) LU88186A1 (de)
MX (1) MX9206236A (de)
NO (1) NO924183L (de)
NZ (1) NZ244921A (de)
TW (1) TW299236B (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5609884A (en) * 1992-08-31 1997-03-11 G. D. Searle & Co. Controlled release naproxen sodium plus naproxen combination tablet
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
JPH07223970A (ja) * 1994-02-10 1995-08-22 Tanabe Seiyaku Co Ltd 消化管内適所放出製剤
US6887461B1 (en) * 1998-10-26 2005-05-03 Genetics Institute, Llc Method of using IL-11 for treating mucositis
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
JPH0940561A (ja) * 1995-08-02 1997-02-10 Fujitsukusu Kk 瀉下剤
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
IN186245B (de) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US6607751B1 (en) * 1997-10-10 2003-08-19 Intellipharamaceutics Corp. Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum
GB9816556D0 (en) * 1998-07-30 1998-09-30 Pfizer Ltd Therapy
AU2004222771B2 (en) * 1998-07-30 2006-09-21 Pfizer Inc. Prevention of Migraine Recurrence
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
US20060240105A1 (en) * 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
US20080118556A1 (en) * 1998-11-02 2008-05-22 Elan Corporation, Plc Modified Release of Compositions Containing a Combination of Carbidopa, Levodopa and Entacapone
US20090149479A1 (en) * 1998-11-02 2009-06-11 Elan Pharma International Limited Dosing regimen
DK1126826T6 (en) * 1998-11-02 2019-06-24 Alkermes Pharma Ireland Ltd Multiparticulate modified release of methylphenidate
PE20001302A1 (es) 1998-11-27 2000-11-30 Hoffmann La Roche Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
EP1064938A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Dosierungsformen zur kontrollierte Wirkstoffabgabe mit mindenstens ein pulsierendem Zeitverlauf
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
US6620431B1 (en) 2000-04-17 2003-09-16 Charles Signorino Shellac film coatings providing release at selected pH and method
US20020028240A1 (en) * 2000-04-17 2002-03-07 Toyohiro Sawada Timed-release compression-coated solid composition for oral administration
IT1318571B1 (it) * 2000-06-09 2003-08-27 Farmaka Srl Composizioni cosmetiche per la cura del cuoio capelluto e dei capelli.
US6500457B1 (en) 2000-08-14 2002-12-31 Peirce Management, Llc Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
JP2004525897A (ja) * 2001-02-14 2004-08-26 グラクソ、ウェルカム、ソシエダッド、アノニマ 医薬処方
US20030072731A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US20030104052A1 (en) * 2001-10-25 2003-06-05 Bret Berner Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20030091630A1 (en) * 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
IL162459A0 (en) * 2001-12-24 2005-11-20 Teva Pharma Dosage form with a core table of active ingredientsheathed in a compressed annular body of powder o r granular material, and process and toolin
US20040013731A1 (en) * 2002-04-08 2004-01-22 Lavipharm Laboratories Inc. Drug-complex microparticles and methods of making/using same
AU2003249478A1 (en) * 2002-07-19 2004-02-09 Ranbaxy Laboratories Limited Taste masked sumatriptan tablets and processes for their preparation
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
US7332183B2 (en) * 2002-12-26 2008-02-19 Pozen Inc. Multilayer dosage forms containing NSAIDs and triptans
WO2004082679A1 (ja) * 2003-03-17 2004-09-30 Takeda Pharmaceutical Company Limited 放出制御組成物
US20040241252A1 (en) * 2003-05-29 2004-12-02 Abney Christopher Charles Pharmaceutical compositions for oral administration comprising lithium carbonate, processes of making the same, and methods of administering the same
JP2006527195A (ja) * 2003-06-06 2006-11-30 グラクソ グループ リミテッド トリプタンおよびnsaidを含む組成物
US7390503B1 (en) * 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20070122480A1 (en) * 2003-09-29 2007-05-31 Cj Corporation Sustained release formulations
GB0400452D0 (en) * 2004-01-09 2004-02-11 Norton Healthcare Ltd A pharmaceutical composition
GB0403628D0 (en) * 2004-02-18 2004-03-24 Arrow Group Ltd Compression-coated tablets and the manufacture thereof
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
ES2624585T3 (es) * 2004-05-28 2017-07-17 Imaginot Pty Ltd. Sistema de suministro de compuesto terapéutico oral
US20060024361A1 (en) * 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
EP1781262A1 (de) * 2004-07-29 2007-05-09 Sanofi-Aventis Pharmazeutische mehrschichtige tablette für die kontrollierte freisetzung von wirkstoffen mit hoch ph-abhängiger löslichkeit
US20060024368A1 (en) * 2004-07-30 2006-02-02 Reza Fassihi Compressed composite delivery system for release-rate modulation of bioactives
US10624858B2 (en) * 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
WO2006035313A1 (en) * 2004-09-29 2006-04-06 Aurobindo Pharma Ltd Solid unit dosage forms of 5-ht1 agonist
EP1799264A2 (de) * 2004-10-08 2007-06-27 Neuromolecular Pharmaceuticals Inc Verfahren und zusammensetzungen zur behandlung von migräne
US20060121112A1 (en) * 2004-12-08 2006-06-08 Elan Corporation, Plc Topiramate pharmaceutical composition
CN101076248A (zh) * 2004-12-09 2007-11-21 塞尔基因公司 使用d-苏型哌甲酯的治疗
CN101184477A (zh) * 2005-04-12 2008-05-21 依兰药物国际有限公司 治疗细菌感染的含头孢菌素控释组合物
US20100136106A1 (en) * 2005-06-08 2010-06-03 Gary Liversidge Modified Release Famciclovir Compositions
JP2009517346A (ja) * 2005-11-28 2009-04-30 イメイジノット ピーティーワイ エルティーディー 治療用化合物の経口送達系
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US9265732B2 (en) 2006-03-06 2016-02-23 Pozen Inc. Dosage forms for administering combinations of drugs
JP5349059B2 (ja) * 2006-03-06 2013-11-20 ポーゼン インコーポレイテッド 薬物の組み合わせを投与するための剤形
EP2010162A4 (de) * 2006-04-03 2013-01-09 Isa Odidi Zusammensetzung zur abgabe eines arzneimittels
JP5457830B2 (ja) 2006-04-03 2014-04-02 オディディ,イサ オルガノゾル被膜を含む制御放出送達デバイス
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2008015018A1 (en) 2006-08-03 2008-02-07 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid disease
US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
KR100885029B1 (ko) * 2007-02-07 2009-02-23 지엘팜텍 주식회사 경구투여용 서방성 삼중정제
EP1970056A1 (de) * 2007-03-15 2008-09-17 Polichem S.A. Zeitspezifische Dosierformen mit verzögerter/pulsatiler Freisetzung
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
CA2749273C (en) 2008-01-09 2018-09-04 Charleston Laboratories, Inc. Pharmaceutical oral dosage form comprising a triptan and an antiemetic
EP2273880B1 (de) * 2008-04-28 2014-12-31 Zogenix, Inc. Neuartige formulierungen zur behandlung von migräne
EP2391369A1 (de) * 2009-01-26 2011-12-07 Nitec Pharma AG Glukokortikoid-behandlung von asthma mit verzögerter freisetzung
NZ582836A (en) * 2009-01-30 2011-06-30 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage
WO2010100657A2 (en) * 2009-03-04 2010-09-10 Fdc Limited A novel oral controlled release dosage forms for water soluble drugs
EP3311667A1 (de) 2009-07-08 2018-04-25 Charleston Laboratories, Inc. Pharmazeutische zusammensetzungen
GB201003766D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Pulsatile drug release
GB201003731D0 (en) * 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
GB201003734D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Delayed prolonged drug delivery
SG10201510564PA (en) 2010-12-22 2016-01-28 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
KR20140075807A (ko) 2010-12-23 2014-06-19 퍼듀 퍼머 엘피 탬퍼 저항성 고체 경구 투여 형태
US9149533B2 (en) 2013-02-05 2015-10-06 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
EP2963013A4 (de) * 2013-02-27 2016-09-14 Shionogi & Co Indol- und azaindolderivate mit jeweils ampk-aktivierender wirkung
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
JP6613251B2 (ja) * 2014-06-13 2019-11-27 アベリー・デニソン・コーポレイション 医療用途に使用される改善された接着剤
EP3423041A4 (de) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. Pharmazeutische zusammensetzungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4892742A (en) * 1985-11-18 1990-01-09 Hoffmann-La Roche Inc. Controlled release compositions with zero order release
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
DE3814532A1 (de) * 1988-04-29 1989-11-09 Bayer Ag Dhp-retard-zubereitung
US4880636A (en) * 1988-05-13 1989-11-14 Franz Robert M Film coated tablet of ranitidine HCl
US5032406A (en) * 1989-02-21 1991-07-16 Norwich Eaton Pharmaceuticals, Inc. Dual-action tablet
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
GB9104890D0 (en) * 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions

Also Published As

Publication number Publication date
GB2262445B (en) 1996-05-15
CZ325792A3 (en) 1993-10-13
KR930007439A (ko) 1993-05-20
US5425950A (en) 1995-06-20
FR2683146A1 (fr) 1993-05-07
ITRM920788A1 (it) 1994-04-29
JPH05194188A (ja) 1993-08-03
GB2262445A (en) 1993-06-23
CA2081709A1 (en) 1993-05-01
TW299236B (de) 1997-03-01
CA2081709C (en) 2003-09-02
LU88186A1 (fr) 1993-05-17
GB9222662D0 (en) 1992-12-09
CH685536A5 (fr) 1995-08-15
EP0546593A1 (de) 1993-06-16
EP0546593B1 (de) 1997-09-03
ITRM920788A0 (it) 1992-10-29
MX9206236A (es) 1993-04-01
AU2746992A (en) 1993-05-06
DE69222006D1 (de) 1997-10-09
NO924183D0 (no) 1992-10-29
IT1263253B (it) 1996-08-05
NZ244921A (en) 1995-04-27
IL103593A0 (en) 1993-03-15
NO924183L (no) 1993-05-03
AU666880B2 (en) 1996-02-29
ES2106818T3 (es) 1997-11-16
FR2683146B1 (fr) 1995-05-12
IE922775A1 (en) 1993-05-05
BE1005490A3 (fr) 1993-08-10

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