DE69221685T2 - Verfahren zur herstellung von optisch aktivem 3-chlor-1-phenyl-propan-1-ol und dessen derivat - Google Patents

Verfahren zur herstellung von optisch aktivem 3-chlor-1-phenyl-propan-1-ol und dessen derivat

Info

Publication number
DE69221685T2
DE69221685T2 DE69221685T DE69221685T DE69221685T2 DE 69221685 T2 DE69221685 T2 DE 69221685T2 DE 69221685 T DE69221685 T DE 69221685T DE 69221685 T DE69221685 T DE 69221685T DE 69221685 T2 DE69221685 T2 DE 69221685T2
Authority
DE
Germany
Prior art keywords
propan
chlorine
phenyl
derivative
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69221685T
Other languages
English (en)
Other versions
DE69221685D1 (de
Inventor
Sadao Tsuboi
Masayuki Negoro
Masanori Utaka
Michio Itoh
Yoshinori Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daicel Corp
Original Assignee
Daicel Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daicel Chemical Industries Ltd filed Critical Daicel Chemical Industries Ltd
Publication of DE69221685D1 publication Critical patent/DE69221685D1/de
Application granted granted Critical
Publication of DE69221685T2 publication Critical patent/DE69221685T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus
    • Y10S435/917—Aspergillus niger
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/939—Rhizopus
DE69221685T 1991-02-19 1992-02-18 Verfahren zur herstellung von optisch aktivem 3-chlor-1-phenyl-propan-1-ol und dessen derivat Expired - Fee Related DE69221685T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2452991 1991-02-19
PCT/JP1992/000159 WO1992014835A1 (en) 1991-02-19 1992-02-18 Process for producing optically active 3-chloro-1-phenyl-1-propanol and derivative thereof

Publications (2)

Publication Number Publication Date
DE69221685D1 DE69221685D1 (de) 1997-09-25
DE69221685T2 true DE69221685T2 (de) 1997-12-11

Family

ID=12140685

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69221685T Expired - Fee Related DE69221685T2 (de) 1991-02-19 1992-02-18 Verfahren zur herstellung von optisch aktivem 3-chlor-1-phenyl-propan-1-ol und dessen derivat

Country Status (4)

Country Link
US (1) US5457052A (de)
EP (1) EP0529085B1 (de)
DE (1) DE69221685T2 (de)
WO (1) WO1992014835A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3133480B2 (ja) * 1992-04-15 2001-02-05 昭和シェル石油株式会社 光学活性ハロゲン含有アルコールの製造方法
DE4217506A1 (de) * 1992-05-27 1993-12-02 Boehringer Mannheim Gmbh Mikrobielle Esterase zur enantioselektiven Spaltung von 1-Arylalkylestern
FR2692909B1 (fr) * 1992-06-24 1995-07-21 Irceba Procede de preparation d'aryl-1 alcanols substitues optiquement purs.
EP0792936B1 (de) * 1996-02-28 2003-01-29 Mitsubishi Chemical Corporation Verfahren zur Herstellung von optisch-aktivem 2-halogen-1-(substituiertes Phenyl)ethanol.
US5959159A (en) * 1997-10-24 1999-09-28 Molecular Optoelectronics Corporation Method for preparing optically active 5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane
WO2002057411A2 (en) * 2000-12-01 2002-07-25 Diversa Corporation Hydrolase enzymes and their use in kinetic resolution
RU2007106863A (ru) * 2004-08-26 2008-08-27 Пфайзер Инк. (US) Энантиоселективное биопреобразование для получения промежуточных соединений ингибитора белка тирозинкиназы
CN105445384B (zh) * 2014-08-26 2018-02-02 广州朗圣药业有限公司 3‑氯苯丙醇光学异构体的分离检测方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2707076B2 (ja) * 1987-05-01 1998-01-28 チッソ株式会社 光学活性化合物の製造法
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
US4868344A (en) * 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
GB9005467D0 (en) * 1990-03-12 1990-05-09 Ici Plc Process for the preparation of optically active intermediates for insecticidal compounds

Also Published As

Publication number Publication date
EP0529085B1 (de) 1997-08-20
US5457052A (en) 1995-10-10
EP0529085A1 (de) 1993-03-03
WO1992014835A1 (en) 1992-09-03
DE69221685D1 (de) 1997-09-25
EP0529085A4 (en) 1994-08-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee