DE69212879D1 - Gastric juice-stable pharmaceutical formulations for the oral administration of bile acids - Google Patents

Gastric juice-stable pharmaceutical formulations for the oral administration of bile acids

Info

Publication number
DE69212879D1
DE69212879D1 DE69212879T DE69212879T DE69212879D1 DE 69212879 D1 DE69212879 D1 DE 69212879D1 DE 69212879 T DE69212879 T DE 69212879T DE 69212879 T DE69212879 T DE 69212879T DE 69212879 D1 DE69212879 D1 DE 69212879D1
Authority
DE
Germany
Prior art keywords
oral administration
pharmaceutical formulations
gastric juice
bile acids
stable pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69212879T
Other languages
German (de)
Other versions
DE69212879T2 (en
Inventor
Egidio Marchi
Gianfranco Tamagnone
Leone Gabriele Rotini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Publication of DE69212879D1 publication Critical patent/DE69212879D1/en
Application granted granted Critical
Publication of DE69212879T2 publication Critical patent/DE69212879T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69212879T 1991-04-12 1992-04-02 Gastric juice-stable pharmaceutical formulations for the oral administration of bile acids Expired - Fee Related DE69212879T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO910113A IT1245890B (en) 1991-04-12 1991-04-12 PHARMACEUTICAL FORMULATIONS FOR ORAL USE GASTRORESANTS CONTAINING BILE ACIDS.

Publications (2)

Publication Number Publication Date
DE69212879D1 true DE69212879D1 (en) 1996-09-26
DE69212879T2 DE69212879T2 (en) 1997-01-23

Family

ID=11337390

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69212879T Expired - Fee Related DE69212879T2 (en) 1991-04-12 1992-04-02 Gastric juice-stable pharmaceutical formulations for the oral administration of bile acids

Country Status (8)

Country Link
US (1) US5380533A (en)
EP (1) EP0509335B1 (en)
JP (1) JP2509045B2 (en)
KR (1) KR970005176B1 (en)
CA (1) CA2065773C (en)
DE (1) DE69212879T2 (en)
ES (1) ES2090395T3 (en)
IT (1) IT1245890B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262172A (en) * 1992-06-19 1993-11-16 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing buffered bile acids
GB9417524D0 (en) * 1994-08-31 1994-10-19 Cortecs Ltd Pharmaceutical compositions
KR100578669B1 (en) * 1997-05-29 2006-12-07 동아제약주식회사 Transparent soft capsule with ursodeoxycholic acid
DE29717252U1 (en) * 1997-09-26 1998-02-19 Falk Pharma Gmbh Drug kit consisting of a budesonide-containing and an ursodeoxycholic acid-containing drug for the treatment of cholestatic liver diseases
US7772220B2 (en) * 2004-10-15 2010-08-10 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
RU2224523C2 (en) 1998-07-24 2004-02-27 Сео Хонг Ю Bile acid-containing aqueous solution and method for its preparing
US7303768B2 (en) 1998-07-24 2007-12-04 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
US20050158408A1 (en) * 1998-07-24 2005-07-21 Yoo Seo H. Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof
US20020068365A1 (en) * 1998-07-28 2002-06-06 Eric H. Kuhrts Controlled release nitric oxide producing agents
DE19906290A1 (en) * 1999-02-15 2000-08-17 Falk Pharma Gmbh Orally administered medicament for treating colon cancer comprises ursodesoxycholic acid in gastric fluid resistant coating to provide direct topical action at target site
BR0108080A (en) * 2000-02-04 2006-02-07 Seo Hong Yoo Preparation of aqueous clear bile acid solution dosage forms
PL357674A1 (en) * 2000-04-19 2004-07-26 Thomas Julius Borody Compositions and therapies for hyperlipidaemia-associated disorders
US7166234B1 (en) * 2000-10-26 2007-01-23 Integrated Biomedical Technology, Inc. Dialdehyde assay
KR100368936B1 (en) * 2000-10-04 2003-01-24 주식회사 대웅 A Medicine Containing Ursodeoxycholic Acid for Prevention and Treatment of Environmental Hormones
CA2403670C (en) * 2001-01-31 2010-02-09 Rohm Gmbh & Co. Kg Multiparticulate drug form comprising at least two differently coated pellet forms
ITMI20012572A1 (en) * 2001-12-06 2003-06-06 Istituto Biochimico Italiano URSODESOXICOLIC ACID MICROGRANULES
US7145125B2 (en) * 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
TW200533391A (en) * 2004-03-25 2005-10-16 Sun Pharmaceutical Ind Ltd Gastric retention drug delivery system
ATE458489T1 (en) * 2004-08-30 2010-03-15 Seo Hong Yoo NERVE PROTECTIVE EFFECT OF DISSOLVED UDCA IN A FOCAL ISCHEMIC MODEL
ATE506955T1 (en) * 2004-10-15 2011-05-15 Seo Hong Yoo COMPOSITIONS FOR REDUCING THE TOXICITY OF CISPLATIN, CARBOPLATIN AND OXALIPLATIN
WO2006050165A2 (en) * 2004-11-01 2006-05-11 Seo Hong Yoo Methods and compositions for reducing neurodegeneration in amyotrophic lateral sclerosis
CN102316889B (en) 2008-11-26 2014-11-26 萨蒂奥根制药公司 Compositions containing satiogens and methods of use
CA2744817C (en) 2008-11-26 2020-07-07 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
BRPI1006145B8 (en) * 2009-01-12 2021-05-25 Biokier Inc composition and method for treating diabetes
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
WO2011038014A2 (en) 2009-09-23 2011-03-31 Biokier, Inc. Composition and method for treatment of diabetes
US20110152204A1 (en) * 2009-12-18 2011-06-23 Satiogen Pharmaceuticals, Inc. Treatment of Obesity or Diabetes with Bile Acid Sequestrants
EP3593802A3 (en) 2010-05-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
PL2771003T3 (en) 2011-10-28 2017-10-31 Lumena Pharmaceuticals Llc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
WO2015142178A1 (en) 2014-03-20 2015-09-24 Disphar International B.V. Bile acid composition with enhanced solubility

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2340060A1 (en) * 1973-08-08 1975-02-20 Scherer Gmbh R P GELATINE RESISTANT CAPSULES AND METHOD FOR MANUFACTURING THEREOF
FR2358144A1 (en) * 1976-07-13 1978-02-10 Lipha Compsn. for treating biliary lithiasis - contains hymecromone and chenodeoxy-cholic acid, with lower cost and better tolerance
IT1101649B (en) * 1978-12-15 1985-10-07 Lehner Ag PROLONGED ACTION PHARMACEUTICAL COMPOSITION CONTAINING BILE ACIDS
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
AT389308B (en) * 1984-12-12 1989-11-27 Medica Pharma Co Ltd METHOD FOR PRODUCING NEW HAEMINARGINATE OR HAEMINLYSINATE
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
IT1197038B (en) * 1986-08-01 1988-11-25 Zambon Spa PHARMACEUTICAL COMPOSITION WITH ANALGESIC ACTIVITY
IT1212141B (en) * 1987-06-03 1989-11-08 So Ri Far S R L PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPY OF CALCULOSIS OF THE BILIARY ROUTES AND BILIARY DYSPEPSIA.
YU183988A (en) * 1988-09-30 1990-08-31 Lek Tovarna Farmacevtskih Process for preparing dispersion pills of dihydroergotoxine

Also Published As

Publication number Publication date
EP0509335B1 (en) 1996-08-21
CA2065773C (en) 1999-01-26
JPH0597676A (en) 1993-04-20
KR970005176B1 (en) 1997-04-14
DE69212879T2 (en) 1997-01-23
IT1245890B (en) 1994-10-25
CA2065773A1 (en) 1992-10-13
ES2090395T3 (en) 1996-10-16
ITBO910113A0 (en) 1991-04-12
JP2509045B2 (en) 1996-06-19
ITBO910113A1 (en) 1992-10-12
EP0509335A1 (en) 1992-10-21
KR920019359A (en) 1992-11-19
US5380533A (en) 1995-01-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee