DE69130605T2 - Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides - Google Patents

Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides

Info

Publication number
DE69130605T2
DE69130605T2 DE69130605T DE69130605T DE69130605T2 DE 69130605 T2 DE69130605 T2 DE 69130605T2 DE 69130605 T DE69130605 T DE 69130605T DE 69130605 T DE69130605 T DE 69130605T DE 69130605 T2 DE69130605 T2 DE 69130605T2
Authority
DE
Germany
Prior art keywords
lower alkyl
aryl
antihypertensive
alpha
substituted pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69130605T
Other languages
German (de)
Other versions
DE69130605D1 (en
Inventor
Moliner Jose Repolles
Coy Francisco Pubill
Llorente Lydia Cabeza
Falco Carlos Malet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacer SA
Original Assignee
Lacer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer SA filed Critical Lacer SA
Application granted granted Critical
Publication of DE69130605D1 publication Critical patent/DE69130605D1/en
Publication of DE69130605T2 publication Critical patent/DE69130605T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Disclosed are dipeptide derivatives of general formula (I) <CHEM> including tautomeric forms thereof, wherein: n is O or an integer of from 1 to 3; R is OH, SH, COOH, NH2, halogen, OR4, SR4, COOR4, NHR4 or N(R4)2, R4 being selected from lower alkyl, optionally substituted, aryl and acyl groups; R1 represents OH, lower alkoxy, optionally substituted, aryl lower alkoxy, aryloxy or disubstituted amino groups; R2 is selected from lower alkyl and amino lower alkyl groups; R3 represents halogen, NO2, lower alkyl, halo lower alkyl, aryl lower alkyl or aryl; and pharmaceutically acceptable salts thereof. Said derivatives are useful, among others, in the treatment of hypertension.
DE69130605T 1991-02-27 1991-02-27 Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides Expired - Fee Related DE69130605T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91102950A EP0500989B1 (en) 1991-02-27 1991-02-27 N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents

Publications (2)

Publication Number Publication Date
DE69130605D1 DE69130605D1 (en) 1999-01-21
DE69130605T2 true DE69130605T2 (en) 1999-05-20

Family

ID=8206465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130605T Expired - Fee Related DE69130605T2 (en) 1991-02-27 1991-02-27 Antihypertensive N- (alpha-substituted pyridyl) carbonyl dipeptides

Country Status (18)

Country Link
US (1) US5432159A (en)
EP (1) EP0500989B1 (en)
JP (1) JPH05507295A (en)
AT (1) ATE174343T1 (en)
AU (1) AU650954B2 (en)
BR (1) BR9204779A (en)
CA (1) CA2081471A1 (en)
CZ (1) CZ280952B6 (en)
DE (1) DE69130605T2 (en)
ES (1) ES2037613B1 (en)
FI (1) FI924850A (en)
HU (1) HUT62313A (en)
NO (1) NO924076L (en)
PL (1) PL167915B1 (en)
PT (1) PT100148B (en)
RO (1) RO111369B1 (en)
RU (1) RU2098424C1 (en)
WO (1) WO1992015608A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014033A1 (en) * 1993-11-19 1995-05-26 Aktiebolaget Astra Novel dipeptide derivatives
EA003528B1 (en) * 1997-04-04 2003-06-26 Пфайзер Продактс Инк. Nicotinamide derivatives, use thereof, pharmaceutical composition, method of treatment and method for selective inhibition of pde4 d isoenzymes
MXPA03006886A (en) 2001-01-31 2003-11-13 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes.
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
SK8792003A3 (en) 2001-01-31 2004-09-08 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes and pharmaceutical composition containing them
ATE305467T1 (en) 2001-01-31 2005-10-15 Pfizer Prod Inc ETHER DERIVATIVES SUITABLE AS INHIBITORS OF PDE4 ISOZYMES
WO2003033471A1 (en) * 2001-10-17 2003-04-24 Tobishi Pharmaceutical Co.,Ltd Novel pyridone derivative and remedial agent for circulatory disease containing the same
EP1469875A1 (en) * 2002-01-29 2004-10-27 Wyeth Compositions and methods for modulating connexin hemichannels
EP1874757A1 (en) * 2005-04-14 2008-01-09 Merck & Co., Inc. Vla-4 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
NZ202232A (en) * 1981-11-06 1985-08-16 Smithkline Beckman Corp N-carboxyalkylproline-containing tripeptides and pharmaceutical compositions
DE3332633A1 (en) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituted carboxylic acid derivatives, process for their preparation, and pharmaceuticals

Also Published As

Publication number Publication date
AU1278392A (en) 1992-10-06
ATE174343T1 (en) 1998-12-15
US5432159A (en) 1995-07-11
RO111369B1 (en) 1996-09-30
BR9204779A (en) 1993-08-17
CZ280952B6 (en) 1996-05-15
JPH05507295A (en) 1993-10-21
PL167915B1 (en) 1995-12-30
NO924076L (en) 1992-12-21
HUT62313A (en) 1993-04-28
EP0500989B1 (en) 1998-12-09
ES2037613B1 (en) 1994-03-16
DE69130605D1 (en) 1999-01-21
NO924076D0 (en) 1992-10-21
PT100148B (en) 1999-06-30
CZ322092A3 (en) 1993-02-17
HU9203324D0 (en) 1993-01-28
PL296625A1 (en) 1993-08-09
EP0500989A1 (en) 1992-09-02
FI924850A0 (en) 1992-10-26
RU2098424C1 (en) 1997-12-10
FI924850A (en) 1992-10-26
AU650954B2 (en) 1994-07-07
CA2081471A1 (en) 1992-08-28
PT100148A (en) 1993-05-31
WO1992015608A1 (en) 1992-09-17
ES2037613A1 (en) 1993-06-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee