DE69130122D1 - Verfahren zur Modulierung der Produktion von sekundären Metaboliten. - Google Patents

Verfahren zur Modulierung der Produktion von sekundären Metaboliten.

Info

Publication number
DE69130122D1
DE69130122D1 DE69130122T DE69130122T DE69130122D1 DE 69130122 D1 DE69130122 D1 DE 69130122D1 DE 69130122 T DE69130122 T DE 69130122T DE 69130122 T DE69130122 T DE 69130122T DE 69130122 D1 DE69130122 D1 DE 69130122D1
Authority
DE
Germany
Prior art keywords
modulating
production
secondary metabolites
organelles
microbodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69130122T
Other languages
English (en)
Other versions
DE69130122T2 (de
Inventor
Der Voort Lucia Helena Mar Van
Roelof Ary Lans Bovenberg
Walraven Henry Muller
Adrianus Johannes Verkley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of DE69130122D1 publication Critical patent/DE69130122D1/de
Publication of DE69130122T2 publication Critical patent/DE69130122T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Hydrogenated Pyridines (AREA)
DE69130122T 1990-03-23 1991-03-25 Verfahren zur Modulierung der Produktion von sekundären Metaboliten. Expired - Fee Related DE69130122T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200695 1990-03-23

Publications (2)

Publication Number Publication Date
DE69130122D1 true DE69130122D1 (de) 1999-01-14
DE69130122T2 DE69130122T2 (de) 1999-02-18

Family

ID=8204972

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130122T Expired - Fee Related DE69130122T2 (de) 1990-03-23 1991-03-25 Verfahren zur Modulierung der Produktion von sekundären Metaboliten.

Country Status (6)

Country Link
EP (1) EP0448180B1 (de)
JP (1) JPH05199897A (de)
AT (1) ATE166392T1 (de)
DE (1) DE69130122T2 (de)
IE (1) IE910956A1 (de)
PT (1) PT97116B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882883A (en) * 1994-09-28 1999-03-16 Novo Nordisk A/S Process for the production of secondary metabolites
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
US5919680A (en) * 1995-11-27 1999-07-06 Isis Innovation Limited Process for the production of SSC's via expandase activity on penicillin G
DE69811039T2 (de) 1997-04-22 2004-01-22 Dsm N.V. Verfahren für die fermentative produktion von deazylierten cephalosporinen.
JP2000512511A (ja) 1997-04-22 2000-09-26 ギスト ブロカデス ベスローテン フェンノートシャップ 脱アシル化セファロスポリンの発酵による製造方法
WO1999060102A2 (en) * 1998-05-19 1999-11-25 Dsm N.V. Improved in vivo production of cephalosporins
EP1179071A2 (de) * 1999-05-21 2002-02-13 Dsm N.V. Regulierung der organellehomöostase in einer zelle
WO2007073947A2 (en) 2005-12-28 2007-07-05 Dsm Ip Assets B.V. Mutant type ii beta- lactam acylases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI104984B (fi) * 1988-08-11 2000-05-15 Dsm Nv Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi

Also Published As

Publication number Publication date
EP0448180A3 (en) 1992-07-08
PT97116B (pt) 1998-10-30
ATE166392T1 (de) 1998-06-15
EP0448180A2 (de) 1991-09-25
JPH05199897A (ja) 1993-08-10
DE69130122T2 (de) 1999-02-18
IE910956A1 (en) 1991-09-25
EP0448180B1 (de) 1998-05-20
PT97116A (pt) 1991-12-31

Similar Documents

Publication Publication Date Title
AT380272B (de) Verfahren zur herstellung von mikroorganismen
AT380694B (de) Verfahren zur herstellung von mikroorganismen
DK162586A (da) Substrat til jordloes plantedyrkning
DE68900007D1 (de) Verfahren zur herstellung von organischen di- und polysulfiden.
DE69006804D1 (de) Verfahren zur Reduzierung des Leistungsbedarfs eines mobilen Funkempfängers.
ATA251879A (de) Verfahren zur herstellung von neuen 4-halogen-9- fluor-3-oxoandrost-4-en- und 4-halogen-9-fluor-3oxoandrosta-1,4-dien-17beta-thiocarbons[ureeste n
DE3675134D1 (de) Verfahren zur herstellung von 2,5-dicetopiperazinen.
ATE14597T1 (de) Verfahren zur enzymatischen herstellung von l-2- amino-4-methylphosphinobuttersaeure.
DE69130122D1 (de) Verfahren zur Modulierung der Produktion von sekundären Metaboliten.
DE3776193D1 (de) Verfahren zum stapeln von rohlingen.
ES2039195T3 (es) Derivado de la pirazolsulfonamida, procedimiento para su fabricacion y herbicida que lo contiene.
PT86619A (pt) Process for preparing alkylmelatonins
DE69109485D1 (de) Verfahren zum entfärben von wasser.
AT379593B (de) Verfahren zur herstellung von neuen trans-2,3dihydro-7-methoxy-3-methyl-2-subst. phenylbenzofuranderivaten
DE3486023D1 (de) Verfahren zur herstellung von urokinase zymogen.
AT374831B (de) Verfahren zur herstellung von 5-brom- oder jod-6,9alpha-oxido-prostaglandinderivaten
DK572181A (da) Fremgangsmaade til fremstilling af 3-oxo-delta1,4-steroider
DE3580340D1 (de) Verfahren zur herstellung von schichtstoffen.
DE69019034D1 (de) Verfahren zur Produktion von Hybridpflanzen von Allium.
ATA592679A (de) Verfahren zur herstellung von alpha-aryl-alpha, alpha-di(omega-aminoalkyl)acetamiden mit disubstituierter aminogruppe
ES8105308A1 (es) Procedimiento para la fabricacion de 4-tiazolidonas,2-subs- tituidas
AT356911B (de) Verfahren zur herstellung von schichtstoffen
ATE258926T1 (de) Verfahren zur herstellung von ranitidin
DE3851523D1 (de) Verfahren zur Herstellung von Thiotepa.
DK0433845T3 (da) Fremgangsmåde til fremstilling af 2-acylamino-9-acyl-6-halogen-puriner

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DSM N.V., HEERLEN, NL

8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8339 Ceased/non-payment of the annual fee