DE69108014T2 - Verfahren zur herstellung von nucleosiden und ihre analogen. - Google Patents

Verfahren zur herstellung von nucleosiden und ihre analogen.

Info

Publication number
DE69108014T2
DE69108014T2 DE69108014T DE69108014T DE69108014T2 DE 69108014 T2 DE69108014 T2 DE 69108014T2 DE 69108014 T DE69108014 T DE 69108014T DE 69108014 T DE69108014 T DE 69108014T DE 69108014 T2 DE69108014 T2 DE 69108014T2
Authority
DE
Germany
Prior art keywords
nucleoside
analogs
cyclonucleoside
cytarabine
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108014T
Other languages
English (en)
Other versions
DE69108014D1 (de
Inventor
Khashayar Karimian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Acic Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2012094 external-priority patent/CA2012094C/en
Priority claimed from CA 2012093 external-priority patent/CA2012093C/en
Application filed by Acic Canada Inc filed Critical Acic Canada Inc
Application granted granted Critical
Publication of DE69108014D1 publication Critical patent/DE69108014D1/de
Publication of DE69108014T2 publication Critical patent/DE69108014T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
DE69108014T 1990-03-13 1991-03-13 Verfahren zur herstellung von nucleosiden und ihre analogen. Expired - Fee Related DE69108014T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA 2012094 CA2012094C (en) 1990-03-13 1990-03-13 Process for producing cytarabine and analogues thereof
CA 2012093 CA2012093C (en) 1990-03-13 1990-03-13 Process for producing 2,2'-cyclocytidine and analogues thereof
PCT/CA1991/000077 WO1991013900A1 (en) 1990-03-13 1991-03-13 Process for producing 2,2'-o-cyclonucleosides, nucleosides, and analogs thereof

Publications (2)

Publication Number Publication Date
DE69108014D1 DE69108014D1 (de) 1995-04-13
DE69108014T2 true DE69108014T2 (de) 1995-07-06

Family

ID=25674007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108014T Expired - Fee Related DE69108014T2 (de) 1990-03-13 1991-03-13 Verfahren zur herstellung von nucleosiden und ihre analogen.

Country Status (8)

Country Link
US (1) US5610292A (de)
EP (1) EP0521923B1 (de)
AT (1) ATE119541T1 (de)
AU (1) AU7473791A (de)
BR (1) BR9106158A (de)
DE (1) DE69108014T2 (de)
HU (1) HUT61566A (de)
WO (1) WO1991013900A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0767657A4 (de) * 1994-06-22 1999-01-20 Nexstar Pharmaceuticals Inc Neues verfahren zur herstellung von bekannten und neuen 2'-modifizierten nukleosiden durch intramolekulare nukleophile substitution
IT1277425B1 (it) 1995-08-03 1997-11-10 Pro Bio Sint Srl Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina
WO1998030575A1 (en) 1997-01-08 1998-07-16 Proligo Llc Bioconjugation of macromolecules
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
EP1186612B1 (de) * 2000-04-13 2006-11-29 Mitsui Chemicals, Inc. Verfahren zur herstellung von cytidin-derivaten
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
WO2003062452A2 (en) 2002-01-23 2003-07-31 Proligo, Llc Methods for the integrated synthesis and purification of oligonucleotides
AU2002361255A1 (en) 2002-12-31 2004-07-22 Proligo Llc Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
EP1668023A1 (de) * 2003-09-12 2006-06-14 Max-Delbrück-Centrum Für Molekulare Medizin B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN1300326C (zh) * 2004-12-22 2007-02-14 华南理工大学 酶催化制备阿糖胞苷酯的方法
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
US8404830B2 (en) 2007-07-17 2013-03-26 Somalogic, Inc. Method for generating aptamers with improved off-rates
EP2265274B1 (de) 2008-03-03 2018-11-21 Tosk, Inc. Methotrexat-adjuvantien zur verringerung der toxizität und anwendungsverfahren dafür
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US8598140B2 (en) 2010-04-12 2013-12-03 Somalogic, Inc. Aptamers to β-NGF and their use in treating β-NGF mediated diseases and disorders
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US9938314B2 (en) 2013-11-21 2018-04-10 Somalogic, Inc. Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652554A (en) * 1982-02-22 1987-03-24 St. Jude Children's Research Hospital Nitro-substituted 1-β-D-arabinofuranosylcytosines
BR9106157A (pt) * 1990-03-13 1993-03-16 Acic Canada Inc Compostos e processo 3'-o-tosil citidina e citosina e processo para producao dos mesmos

Also Published As

Publication number Publication date
HUT61566A (en) 1993-01-28
BR9106158A (pt) 1993-03-16
AU7473791A (en) 1991-10-10
EP0521923A1 (de) 1993-01-13
EP0521923B1 (de) 1995-03-08
HU9202906D0 (en) 1992-11-30
WO1991013900A1 (en) 1991-09-19
ATE119541T1 (de) 1995-03-15
US5610292A (en) 1997-03-11
DE69108014D1 (de) 1995-04-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee