DE69022176T2 - Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. - Google Patents
Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.Info
- Publication number
- DE69022176T2 DE69022176T2 DE69022176T DE69022176T DE69022176T2 DE 69022176 T2 DE69022176 T2 DE 69022176T2 DE 69022176 T DE69022176 T DE 69022176T DE 69022176 T DE69022176 T DE 69022176T DE 69022176 T2 DE69022176 T2 DE 69022176T2
- Authority
- DE
- Germany
- Prior art keywords
- alkynyladenosine
- production
- intermediate connection
- derivative
- stable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Ladders (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15751789 | 1989-06-20 | ||
JP472790 | 1990-01-13 | ||
PCT/JP1990/000807 WO1990015812A1 (fr) | 1989-06-20 | 1990-06-20 | Intermediaire de synthese de 2-alkynyladenosine, production de cet intermediaire, production de 2-alkynyladenosine avec cet intermediaire et derive stable de 2-alkynyladenosine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69022176D1 DE69022176D1 (de) | 1995-10-12 |
DE69022176T2 true DE69022176T2 (de) | 1996-02-15 |
Family
ID=26338545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69022176T Expired - Lifetime DE69022176T2 (de) | 1989-06-20 | 1990-06-20 | Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5283327A (de) |
EP (1) | EP0429681B1 (de) |
KR (1) | KR920700218A (de) |
AT (1) | ATE127472T1 (de) |
CA (1) | CA2035038C (de) |
DE (1) | DE69022176T2 (de) |
ES (1) | ES2077070T3 (de) |
WO (1) | WO1990015812A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189027A (en) | 1990-11-30 | 1993-02-23 | Yamasa Shoyu Kabushiki Kaisha | 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases |
JP2740362B2 (ja) * | 1991-02-12 | 1998-04-15 | ヤマサ醤油株式会社 | 安定な固体状2‐オクチニルアデノシンおよびその製造法 |
WO2000044763A2 (en) * | 1999-02-01 | 2000-08-03 | University Of Virginia Patent Foundation | Compositions for treating inflammatory response |
US6403567B1 (en) * | 1999-06-22 | 2002-06-11 | Cv Therapeutics, Inc. | N-pyrazole A2A adenosine receptor agonists |
US6180615B1 (en) * | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
USRE47351E1 (en) | 1999-06-22 | 2019-04-16 | Gilead Sciences, Inc. | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists |
CA2439222C (en) * | 2000-02-23 | 2009-07-14 | Cv Therapeutics, Inc. | Identification of partial agonists of the a2a adenosine receptor |
US7683037B2 (en) * | 2002-07-29 | 2010-03-23 | Gilead Palo Alto, Inc. | Myocardial perfusion imaging method |
US8470801B2 (en) | 2002-07-29 | 2013-06-25 | Gilead Sciences, Inc. | Myocardial perfusion imaging methods and compositions |
US20050020915A1 (en) * | 2002-07-29 | 2005-01-27 | Cv Therapeutics, Inc. | Myocardial perfusion imaging methods and compositions |
US7655636B2 (en) * | 2004-10-20 | 2010-02-02 | Gilead Palo Alto, Inc. | Use of A2A adenosine receptor agonists |
EP1989214B8 (de) | 2006-02-03 | 2016-12-21 | Gilead Sciences, Inc. | Verfahren zur herstellung eines a2a-adenosinrezeptoragonisten sowie dessen polymorphe |
JP2009541354A (ja) * | 2006-06-22 | 2009-11-26 | シーブイ・セラピューティクス・インコーポレイテッド | 虚血の治療におけるa2aアデノシン受容体アゴニストの使用 |
US20090081120A1 (en) * | 2006-09-01 | 2009-03-26 | Cv Therapeutics, Inc. | Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods |
EP2056834B1 (de) * | 2006-09-01 | 2012-08-29 | Gilead Sciences, Inc. | Verfahren und zusammensetzungen für erhöhte patientenverträglichkeit während myokardialer bildgebungsverfahren |
WO2008042796A2 (en) * | 2006-09-29 | 2008-04-10 | Cv Therapeutics, Inc. | Methods for myocardial imaging in patients having a history of pulmonary disease |
WO2008086096A2 (en) * | 2007-01-03 | 2008-07-17 | Cv Therapeutics, Inc. | Myocardial perfusion imaging |
MX2011003168A (es) * | 2008-09-29 | 2011-05-19 | Gilead Sciences Inc | Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples. |
US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
KR20150036767A (ko) | 2012-08-01 | 2015-04-07 | 루이스 앤드 클라크 파마슈티컬스, 인코포레이티드 | A2a 효능제로서의 n-알킬 2-(이치환된)알키닐아데노신-5-유론아미드 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6299395A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
WO1990005526A1 (en) * | 1988-11-15 | 1990-05-31 | Yamasa Shoyu Kabushiki Kaisha | Agent for treatment and prophylaxis of ischemic disease of heart or brain |
-
1990
- 1990-06-20 DE DE69022176T patent/DE69022176T2/de not_active Expired - Lifetime
- 1990-06-20 CA CA002035038A patent/CA2035038C/en not_active Expired - Lifetime
- 1990-06-20 WO PCT/JP1990/000807 patent/WO1990015812A1/ja active IP Right Grant
- 1990-06-20 KR KR1019910700169A patent/KR920700218A/ko not_active Application Discontinuation
- 1990-06-20 US US07/655,354 patent/US5283327A/en not_active Expired - Lifetime
- 1990-06-20 EP EP90909403A patent/EP0429681B1/de not_active Expired - Lifetime
- 1990-06-20 ES ES90909403T patent/ES2077070T3/es not_active Expired - Lifetime
- 1990-06-20 AT AT90909403T patent/ATE127472T1/de not_active IP Right Cessation
-
1993
- 1993-11-10 US US08/149,943 patent/US5459254A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0429681A1 (de) | 1991-06-05 |
EP0429681B1 (de) | 1995-09-06 |
EP0429681A4 (en) | 1992-03-11 |
DE69022176D1 (de) | 1995-10-12 |
ES2077070T3 (es) | 1995-11-16 |
KR920700218A (ko) | 1992-02-19 |
US5283327A (en) | 1994-02-01 |
ATE127472T1 (de) | 1995-09-15 |
WO1990015812A1 (fr) | 1990-12-27 |
US5459254A (en) | 1995-10-17 |
CA2035038C (en) | 1998-12-29 |
CA2035038A1 (en) | 1990-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE |