DE69021645T2 - N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, processes for their preparation and their use as medicaments. - Google Patents

N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, processes for their preparation and their use as medicaments.

Info

Publication number
DE69021645T2
DE69021645T2 DE69021645T DE69021645T DE69021645T2 DE 69021645 T2 DE69021645 T2 DE 69021645T2 DE 69021645 T DE69021645 T DE 69021645T DE 69021645 T DE69021645 T DE 69021645T DE 69021645 T2 DE69021645 T2 DE 69021645T2
Authority
DE
Germany
Prior art keywords
lower alkyl
alkyl
chem
alkoxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69021645T
Other languages
German (de)
Other versions
DE69021645D1 (en
Inventor
Joseph T Strupczewski
Grover C Helsley
Yulin Chiang
Kenneth J Bordeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69021645D1 publication Critical patent/DE69021645D1/en
Publication of DE69021645T2 publication Critical patent/DE69021645T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

This invention related to compounds of the formula: <CHEM> wherein X is -O-, -S-, - @H, or -@-R<2>; p is 1 or 2; Y is hydrogen, C1 to C6 alkyl, -OH, Cl, F, Br, I, C1 to C6 alkoxy, -CF3, NO2, or -NH2, when p is 1; Y is C1 to C6 alkoxy when p is 2 and X is -O-; R<2> is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, and phenyl sulfonyl groups; Z is -CH- or -N-; n is 2, 3, 4, or 5; R is hydrogen, alkyl, C1 - C6-alkoxy, hydroxyl, carboxyl, Cl, F, Br, I, amino, C1 - C6-mono or-dialryl amino, -NO2, lower alkyl thiol -OCF3, cyano, acylamino, -CF3, trifluoroacetyl, aminocarbonyl, <CHEM> where alkyl is lower alkyl; aryl is phenyl or <CHEM> R1 is hydrogen, lower alkyl, C1 - C6 alkoxy, hydroxy, Cl, F, Br, I, C1 - C6 alkyl amino, -NO2, -CN, -CF3, -OCF3; and heteroaryl is <CHEM> where Q is -O-, -S-, - @H, -CH=N; R3 is hydrogen, lower alkyl, or acyl; and m is 1, 2, or 3; or a pharmaceutically acceptable acid addition salt thereof. The invention relates further to a process for the preparation of the above compounds and their use as medicaments having antipsychotic and/or analgetic activity.
DE69021645T 1989-05-19 1990-05-16 N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, processes for their preparation and their use as medicaments. Expired - Lifetime DE69021645T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US45679089A 1989-12-29 1989-12-29

Publications (2)

Publication Number Publication Date
DE69021645D1 DE69021645D1 (en) 1995-09-21
DE69021645T2 true DE69021645T2 (en) 1996-02-22

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69021645T Expired - Lifetime DE69021645T2 (en) 1989-05-19 1990-05-16 N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, processes for their preparation and their use as medicaments.

Country Status (24)

Country Link
EP (1) EP0402644B1 (en)
JP (1) JPH0662580B2 (en)
KR (1) KR0157308B1 (en)
CN (2) CN1086387C (en)
AT (1) ATE126512T1 (en)
AU (1) AU640653B2 (en)
CA (1) CA2017193C (en)
CZ (1) CZ282385B6 (en)
DD (1) DD300433A5 (en)
DE (1) DE69021645T2 (en)
DK (1) DK0402644T3 (en)
ES (1) ES2076253T3 (en)
FI (2) FI104072B (en)
GR (1) GR3017447T3 (en)
HK (2) HK1006710A1 (en)
HU (2) HU218200B (en)
IE (1) IE68431B1 (en)
IL (1) IL94425A (en)
NO (1) NO177301C (en)
NZ (1) NZ233710A (en)
PL (1) PL163965B1 (en)
PT (1) PT94084B (en)
RU (3) RU2147583C1 (en)
SK (1) SK279474B6 (en)

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AU672182B2 (en) * 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
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CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
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DK60793D0 (en) * 1993-05-26 1993-05-26 Novo Nordisk As CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE
DK60593D0 (en) * 1993-05-26 1993-05-26 Novo Nordisk As CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
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KR100308748B1 (en) * 1996-01-05 2001-12-12 게리 디. 스트리트, 스티븐 엘. 네스비트 4,5-Dihydronaphth[1,2-C]Isoxazoles and Derivatives Thereof Having CNS Activity
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AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
ES2370634T3 (en) * 2001-08-31 2011-12-21 Novartis Ag OPTICAL ISOMERS OF AN ILOPERIDONE METABOLITE.
ATE493129T1 (en) 2001-10-30 2011-01-15 Novartis Pharma Gmbh DEPOT FORMULATIONS OF ILOPERIDONE AND A STAR-SHAPED POLYMER
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BR0314393A (en) * 2002-09-17 2005-07-19 Warner Lambert Co Heterocyclic Substituted Piperazines for the Treatment of Schizophrenia
MXPA05004273A (en) * 2002-11-08 2005-10-18 Warner Lambert Co Phenylalkyl and pyridylalkyl piperazine derivatives.
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
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Also Published As

Publication number Publication date
FI19991869A (en) 1999-09-02
AU5577090A (en) 1990-11-22
PL163965B1 (en) 1994-05-31
DE69021645D1 (en) 1995-09-21
CZ242590A3 (en) 1997-03-12
KR0157308B1 (en) 1998-11-16
IE68431B1 (en) 1996-06-12
DK0402644T3 (en) 1996-01-02
RU2239434C2 (en) 2004-11-10
NZ233710A (en) 1992-05-26
ATE126512T1 (en) 1995-09-15
JPH0662580B2 (en) 1994-08-17
EP0402644B1 (en) 1995-08-16
CN1305812A (en) 2001-08-01
CN1223348C (en) 2005-10-19
CA2017193C (en) 2000-06-27
HK1006710A1 (en) 1999-03-12
FI104072B1 (en) 1999-11-15
NO177301B (en) 1995-05-15
RU2062776C1 (en) 1996-06-27
PT94084B (en) 1996-12-31
DD300433A5 (en) 1992-06-11
PL285247A1 (en) 1991-02-11
HU211853A9 (en) 1995-12-28
RU2147583C1 (en) 2000-04-20
NO902214L (en) 1990-11-20
JPH0363263A (en) 1991-03-19
NO902214D0 (en) 1990-05-18
FI902449A0 (en) 1990-05-17
ES2076253T3 (en) 1995-11-01
HU903090D0 (en) 1990-09-28
CA2017193A1 (en) 1990-11-19
EP0402644A1 (en) 1990-12-19
PT94084A (en) 1991-01-08
SK242590A3 (en) 1998-11-04
CN1086387C (en) 2002-06-19
FI104072B (en) 1999-11-15
HK1038316A1 (en) 2002-03-15
IL94425A0 (en) 1991-03-10
NO177301C (en) 1995-08-23
IL94425A (en) 1994-02-27
GR3017447T3 (en) 1995-12-31
HUT58720A (en) 1992-03-30
HU218200B (en) 2000-06-28
IE901809L (en) 1990-11-19
CN1048037A (en) 1990-12-26
KR900018070A (en) 1990-12-20
CZ282385B6 (en) 1997-07-16
AU640653B2 (en) 1993-09-02
SK279474B6 (en) 1998-11-04

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