DE69018777D1 - Benzothiazepine. - Google Patents

Benzothiazepine.

Info

Publication number
DE69018777D1
DE69018777D1 DE69018777T DE69018777T DE69018777D1 DE 69018777 D1 DE69018777 D1 DE 69018777D1 DE 69018777 T DE69018777 T DE 69018777T DE 69018777 T DE69018777 T DE 69018777T DE 69018777 D1 DE69018777 D1 DE 69018777D1
Authority
DE
Germany
Prior art keywords
benzothiazepines
pharmaceuticals
certain
useful intermediates
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69018777T
Other languages
English (en)
Other versions
DE69018777T2 (de
Inventor
David R Borcherding
Daniel E Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Application granted granted Critical
Publication of DE69018777D1 publication Critical patent/DE69018777D1/de
Publication of DE69018777T2 publication Critical patent/DE69018777T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, ***e
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Paper (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
DE69018777T 1989-11-22 1990-11-20 Benzothiazepine. Expired - Lifetime DE69018777T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/440,383 US5001236A (en) 1989-11-22 1989-11-22 Benzothiazepines

Publications (2)

Publication Number Publication Date
DE69018777D1 true DE69018777D1 (de) 1995-05-24
DE69018777T2 DE69018777T2 (de) 1995-08-24

Family

ID=23748542

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018777T Expired - Lifetime DE69018777T2 (de) 1989-11-22 1990-11-20 Benzothiazepine.

Country Status (9)

Country Link
US (1) US5001236A (de)
EP (1) EP0429060B1 (de)
JP (1) JP3029452B2 (de)
AT (1) ATE121393T1 (de)
AU (1) AU632637B2 (de)
CA (1) CA2030162C (de)
DE (1) DE69018777T2 (de)
ES (1) ES2073495T3 (de)
MX (1) MX9203684A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946840A (en) * 1989-04-06 1990-08-07 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5378698A (en) * 1991-10-21 1995-01-03 Shionogi & Co., Ltd. Benzothiazepine derivatives
ZA94284B (en) * 1993-01-27 1994-08-17 Shionogi & Co Process for preparing benzothiazepine derivatives
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
CN106188099B (zh) * 2016-07-21 2021-05-07 新乡医学院 一种1,4-硫氮卓衍生物及其合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3075967A (en) * 1961-06-12 1963-01-29 Olin Mathieson Benzothiazines
FR1552840A (de) * 1967-06-26 1969-01-10
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
US4690935A (en) * 1983-03-31 1987-09-01 Wayne State University Inhibition of tumor growth and metastasis with calcium channel blocker compounds
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
IT1206505B (it) * 1983-07-22 1989-04-27 Schiapparelli Farma Nuovi derivati benzotiazepinonici, metodo per la loro preparazione e composizioni farmaceutiche che licontengono.
US4512988A (en) * 1984-03-01 1985-04-23 E. R. Squibb & Sons, Inc. Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4694002A (en) * 1986-08-21 1987-09-15 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
CA2030160A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Benzothiazepine metastasis treatment
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators

Also Published As

Publication number Publication date
MX9203684A (es) 1992-09-01
AU632637B2 (en) 1993-01-07
DE69018777T2 (de) 1995-08-24
EP0429060B1 (de) 1995-04-19
CA2030162A1 (en) 1991-05-23
CA2030162C (en) 2001-07-24
ATE121393T1 (de) 1995-05-15
EP0429060A2 (de) 1991-05-29
AU6670690A (en) 1991-05-30
EP0429060A3 (en) 1991-12-11
JP3029452B2 (ja) 2000-04-04
JPH03170467A (ja) 1991-07-24
US5001236A (en) 1991-03-19
ES2073495T3 (es) 1995-08-16

Similar Documents

Publication Publication Date Title
PT775126E (pt) 1,1-dioxidos de 1,4-benzotiazepina hipolipidemica
BR1100989A (pt) Composto e composição de matéria
MX9201212A (es) Agentes de control biologico.
NL980022I2 (nl) Dibenzothiazepine.
FI953489A0 (fi) 2,6-diaminopuriinijohdannaisia
ZA953288B (en) Substituted pyridylpyrazoles
FI865025A (fi) 2-(3,5-dihalogen-4-aminobensyl) imidazoliner.
DE59002341D1 (de) Praezisions-referenzspannungsquelle.
DE69018777D1 (de) Benzothiazepine.
DE59105114D1 (de) Knochenersatz.
BR9408162A (pt) Derivados de ácido 2,3,5,6-tetrafluorbenzóico
NO973624L (no) Vasokonstriktive substituerte 2,3-dihydro-1,4-dioksinopiperidiner
MA23936A1 (fr) Dimaleate de n,n-diethyl-8, 8-dipropyl-2-azaspiro (4,5) decane -2-propanamine
ITMI913438A1 (it) Dibenzo (d, g) (1, 3, 2) diossafosfocine sostituite
DE3674284D1 (de) Kationische 1,2,3-thiadiazolazoverbindungen.
NO944024D0 (no) 1,2-dihydro-2-okso-pyridin
DE69021494D1 (de) 1,1,1-Trifluor-2-Hydroxyverbindungen.
NO943791D0 (no) 1,2-dihydro-2-okso-3-metylsulfonylaminometylpyridin
NO942212D0 (no) 13,14-dihydro-PGF2
ITTO920827A0 (it) Unita' di azionamento lineare.
FI891900A (fi) Utan besvaer med vatten paofyllbar julgransfot.
MX9203296A (es) Proteinas bmp-7.
FR2670867B1 (fr) Support de source d'eclairage.
MX9202951A (es) Nueva dibenzotiazepina antipsicotica.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition