DE68928802D1 - 1,2,4-benzotriazin-n-oxidderivate als radiosensibilisierende und selektive cytotoxische mittel - Google Patents

1,2,4-benzotriazin-n-oxidderivate als radiosensibilisierende und selektive cytotoxische mittel

Info

Publication number
DE68928802D1
DE68928802D1 DE68928802T DE68928802T DE68928802D1 DE 68928802 D1 DE68928802 D1 DE 68928802D1 DE 68928802 T DE68928802 T DE 68928802T DE 68928802 T DE68928802 T DE 68928802T DE 68928802 D1 DE68928802 D1 DE 68928802D1
Authority
DE
Germany
Prior art keywords
cytotoxic agents
benzotriazine
radiosensitizing
oxide derivatives
selective cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68928802T
Other languages
English (en)
Other versions
DE68928802T2 (de
Inventor
William Lee
J Brown
Edward Grange
Abelardo Martinez
Michael Tracy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of DE68928802D1 publication Critical patent/DE68928802D1/de
Application granted granted Critical
Publication of DE68928802T2 publication Critical patent/DE68928802T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
DE68928802T 1988-03-18 1989-03-15 1,2,4-benzotriazin-n-oxidderivate als radiosensibilisierende und selektive cytotoxische mittel Expired - Fee Related DE68928802T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16987388A 1988-03-18 1988-03-18
PCT/US1989/001037 WO1989008647A1 (en) 1988-03-18 1989-03-15 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (2)

Publication Number Publication Date
DE68928802D1 true DE68928802D1 (de) 1998-10-08
DE68928802T2 DE68928802T2 (de) 1999-04-01

Family

ID=22617563

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928802T Expired - Fee Related DE68928802T2 (de) 1988-03-18 1989-03-15 1,2,4-benzotriazin-n-oxidderivate als radiosensibilisierende und selektive cytotoxische mittel

Country Status (14)

Country Link
EP (1) EP0413706B1 (de)
JP (1) JP2793312B2 (de)
KR (1) KR0140894B1 (de)
AT (1) ATE170515T1 (de)
AU (1) AU637572B2 (de)
CA (1) CA1339217C (de)
DE (1) DE68928802T2 (de)
DK (1) DK175885B1 (de)
ES (1) ES2013123A6 (de)
IE (1) IE62911B1 (de)
NO (1) NO179005C (de)
NZ (1) NZ228323A (de)
PT (1) PT90039B (de)
WO (1) WO1989008647A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929050T2 (de) 1989-09-18 2000-02-03 Sri International, Menlo Park 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel
US5110347A (en) * 1990-11-26 1992-05-05 E. I Du Pont De Nemours And Company Substituted fused heterocyclic herbicides
EP1723125A4 (de) * 2004-03-01 2009-11-18 Auckland Uniservices Ltd Neue 1,2,4-benzotriazin-1,4-dioxide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (de) * 1963-10-22 1970-03-15 Siegfried Ag Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) * 1968-11-16 1970-06-11 Bayer Ag Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) * 1972-11-15 1978-03-30 Bayer Ag, 5090 Leverkusen Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IL44058A (en) * 1973-02-02 1978-10-31 Ciba Geigy Ag 3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
SE7501624L (de) * 1974-03-15 1975-09-16 Ciba Geigy Ag
DE2538179C2 (de) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) * 1977-09-10 1979-03-22 Bayer Ag Mittel zur bekaempfung von pflanzenbakteriosen
WO1988002366A1 (en) * 1986-09-25 1988-04-07 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Also Published As

Publication number Publication date
AU3433789A (en) 1989-10-05
KR900700466A (ko) 1990-08-13
PT90039A (pt) 1989-11-10
DK175885B1 (da) 2005-05-23
NO179005B (no) 1996-04-09
CA1339217C (en) 1997-08-05
ES2013123A6 (es) 1990-04-16
AU637572B2 (en) 1993-06-03
DK223090D0 (da) 1990-09-17
NO179005C (no) 1996-07-17
NO904003L (no) 1990-09-13
NO904003D0 (no) 1990-09-13
KR0140894B1 (ko) 1998-06-01
IE890721L (en) 1989-09-18
EP0413706B1 (de) 1998-09-02
JPH03505867A (ja) 1991-12-19
WO1989008647A1 (en) 1989-09-21
PT90039B (pt) 1994-05-31
NZ228323A (en) 1992-09-25
ATE170515T1 (de) 1998-09-15
EP0413706A1 (de) 1991-02-27
IE62911B1 (en) 1995-03-08
DK223090A (da) 1990-11-15
JP2793312B2 (ja) 1998-09-03
DE68928802T2 (de) 1999-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee