DE68926303D1 - Peptide und antikörper, die die integrin-ligandbindung inhibieren - Google Patents

Peptide und antikörper, die die integrin-ligandbindung inhibieren

Info

Publication number
DE68926303D1
DE68926303D1 DE68926303T DE68926303T DE68926303D1 DE 68926303 D1 DE68926303 D1 DE 68926303D1 DE 68926303 T DE68926303 T DE 68926303T DE 68926303 T DE68926303 T DE 68926303T DE 68926303 D1 DE68926303 D1 DE 68926303D1
Authority
DE
Germany
Prior art keywords
antibodies
integrine
ligandbinding
peptides
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926303T
Other languages
English (en)
Other versions
DE68926303T2 (de
Inventor
Edward Plow
Souza Stanley D
Mark Ginsberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/252,674 external-priority patent/US5149780A/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of DE68926303D1 publication Critical patent/DE68926303D1/de
Application granted granted Critical
Publication of DE68926303T2 publication Critical patent/DE68926303T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68926303T 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin-ligandbindung inhibieren Expired - Fee Related DE68926303T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/252,674 US5149780A (en) 1988-10-03 1988-10-03 Peptides and antibodies that inhibit integrin-ligand binding
US07/415,025 US5204445A (en) 1988-10-03 1989-10-02 Peptides and antibodies that inhibit integrin-ligand binding
PCT/US1989/004371 WO1990003983A1 (en) 1988-10-03 1989-10-03 Peptides and antibodies that inhibit integrin-ligand binding

Publications (2)

Publication Number Publication Date
DE68926303D1 true DE68926303D1 (de) 1996-05-23
DE68926303T2 DE68926303T2 (de) 1996-11-21

Family

ID=26942544

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926303T Expired - Fee Related DE68926303T2 (de) 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin-ligandbindung inhibieren

Country Status (10)

Country Link
US (1) US5204445A (de)
EP (1) EP0436660B1 (de)
AT (1) ATE136908T1 (de)
AU (1) AU4427389A (de)
CA (1) CA2000048A1 (de)
DE (1) DE68926303T2 (de)
ES (1) ES2024728A6 (de)
GR (1) GR1001291B (de)
PT (1) PT91888A (de)
WO (1) WO1990003983A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015076A2 (en) * 1989-06-02 1990-12-13 The Johns Hopkins University School Of Medicine MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE ADHESION RECEPTOR β-CHAIN, METHODS OF PRODUCING THESE ANTIBODIES AND USE THEREFORE
GB8914020D0 (en) † 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
WO1992003473A1 (en) * 1990-08-27 1992-03-05 Cetus Corporation Cd18 peptide medicaments for the treatment of disease
CA2109332A1 (en) * 1991-05-03 1992-11-04 Elaine Tuomanen Antibody recognizing endothelial cell ligand for leukocyte cr3
DE69225971D1 (de) * 1991-07-01 1998-07-23 Blood Center Of Southeastern W Pen-polymorphismus von menschlichem plättchenmembran-glykoprotein-iiia und diagnostische und therapeutische anwendung davon
US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
NO933860L (no) * 1992-10-30 1994-05-02 Bristol Myers Squibb Co Ekstracellulære matriks-reseptorligander som modulerer leukocyttfunksjon
EP0762886A4 (de) * 1994-04-19 1999-03-31 Univ Kansas Icam-1/lfa-1 kurzkettigen peptide und methoden zu deren verwendung
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6465253B1 (en) * 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US6187993B1 (en) 1995-02-25 2001-02-13 Imperial Cancer Research Technology Limited Transgenic animals as model of psoriasis
US6783980B2 (en) * 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
DE69638058D1 (de) * 1995-06-15 2009-11-26 Crucell Holland Bv Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie
US5817750A (en) * 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
CA2242647A1 (en) 1996-01-10 1997-07-17 Amersham Health As Contrast media
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
US20040043489A1 (en) * 1998-07-08 2004-03-04 Menzo Havenga Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use
US20030017138A1 (en) * 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) * 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6913922B1 (en) * 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US20050232900A1 (en) * 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6492169B1 (en) * 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US7129052B1 (en) 2000-07-12 2006-10-31 The United States Of America As Represented By The Department Of Health And Human Services Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins
AU6090200A (en) * 1999-07-15 2001-02-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins
EP1157999A1 (de) * 2000-05-24 2001-11-28 Introgene B.V. Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen
AU2002223556A1 (en) * 2000-09-20 2002-04-02 Crucell Holland B.V. Transduction of dendritic cells using adenoviral vectors
DE60138403D1 (de) * 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
CA2439852A1 (en) * 2001-03-02 2002-09-12 Christine Dingivan Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists
WO2003062400A2 (en) * 2002-01-24 2003-07-31 The Scripps Research Institute Fiber shaft modifications for efficient targeting
JP2005525368A (ja) * 2002-03-04 2005-08-25 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストをＨＭＧ−ＣｏＡ還元酵素阻害剤またはビスフォスフォネートと併用投与する障害の予防または治療方法
JP2005533001A (ja) * 2002-03-04 2005-11-04 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法
JP2005535572A (ja) 2002-04-12 2005-11-24 メディミューン，インコーポレーテッド 組換え抗インターロイキン−９抗体
MXPA04008891A (es) * 2002-04-25 2004-11-26 Crucell Holland Bv Medios y metodos para la produccion de vectores de adenovirus.
US20040176272A1 (en) * 2003-01-30 2004-09-09 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
CA2521826C (en) 2003-04-11 2013-08-06 Jennifer L. Reed Recombinant il-9 antibodies and uses thereof
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
WO2006047639A2 (en) 2004-10-27 2006-05-04 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
WO2008008373A2 (en) 2006-07-11 2008-01-17 Arubor Corp Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
LT2068889T (lt) 2006-08-10 2020-02-10 Roy C. Levitt Anakinra, naudojama bronchiolito obliteranso sindromo gydymui
WO2011103490A2 (en) * 2010-02-18 2011-08-25 The Regents Of The University Of California INTEGRIN αVβ8 NEUTRALIZING ANTIBODY

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006592A1 (en) * 1987-02-26 1988-09-07 Dana-Farber Cancer Institute, Inc. Cloning of lfa-1
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion

Also Published As

Publication number Publication date
ATE136908T1 (de) 1996-05-15
EP0436660B1 (de) 1996-04-17
AU4427389A (en) 1990-05-01
US5204445A (en) 1993-04-20
DE68926303T2 (de) 1996-11-21
WO1990003983A1 (en) 1990-04-19
ES2024728A6 (es) 1992-03-01
PT91888A (pt) 1990-04-30
GR890100632A (en) 1990-11-29
CA2000048A1 (en) 1990-04-03
EP0436660A4 (en) 1992-02-12
GR1001291B (el) 1993-07-30
EP0436660A1 (de) 1991-07-17

Similar Documents

Publication Publication Date Title
DE68926303D1 (de) Peptide und antikörper, die die integrin-ligandbindung inhibieren
DE3856560D1 (de) Dem menschlichen gewebefaktor ähnliche dns-segmente, polypeptide und antikörper
BR9507618A (pt) Frações polipeptidicas solúveis da proteína lag-3 processo de produção composição terapêutica anticorpos anti-idiotipo
EP1190043A4 (de) Glykoprotein vi und dessen anwendungen
ATE353365T1 (de) Neue b7-4 moleküle und deren verwendungen
DE69129803D1 (de) Wasserlösliche peptidanaloguen mit bindungstellen
DE59708952D1 (de) Fusionspolypeptid zur beeinflussung von wechselwirkungen zwischen proteinen
GR3019849T3 (en) Acute pancreatitis associated protein and means for the diagnosis of acute pancreatitis
EP0686161A4 (de) Alpha untereinheit des humanen beta-2 integrins
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
IL69469A (en) Polypeptide having human h1-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
EP1009752A4 (de) Neue moleküle aus der familieder tango-77-ähnlichen proteine und ihre verewendungen.
ATE354656T1 (de) Von menschlichem tumor stammendes polypeptidhormon phosphatonin
ATE321873T1 (de) Rekombinante aav-vektoren für die gentherapie von hämophilie a
DK295188D0 (da) Fibronectinbindende protein og fremgangsmaade til fremstilling heraf
ATE464383T1 (de) Tumor antigen
DE69333952D1 (de) Klonering von dem gen für das t gondii protein gp 28.5 peptidfragmente aus diesem protein und ihre verwendungen.
UA72875C2 (uk) БІЛКИ, ЯКІ ЗВ'ЯЗУЮТЬСЯ З <font face="Symbol">b</font>-АМІЛОЇДНИМ ПЕПТИДОМ ТА ПОЛІНУКЛЕОТИДИ, ЩО ЇХ КОДУЮТЬ
NO922421D0 (no) Collagenbindende protein, samt fremstilling derav
DK0990703T3 (da) Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf
DE69328060D1 (de) Angiotensin-II Typ-1 Rezeptor und dessen Herstellung
ATE171217T1 (de) Methoden zur synthese und reinigung von peptiden
HK1037209A1 (en) Proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses
CA2218755A1 (en) Monoclonal antibody to human beta 2 integrin alpha subunit
PT1241179E (pt) Proteína humana possuindo actividade antiproliferativa in vitro

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee