DE60334382D1 - Verfahren zur herstellung von temperaturinduzierten tumorzell-lysaten zur verwendung als immunogene verbindungen - Google Patents
Verfahren zur herstellung von temperaturinduzierten tumorzell-lysaten zur verwendung als immunogene verbindungenInfo
- Publication number
- DE60334382D1 DE60334382D1 DE60334382T DE60334382T DE60334382D1 DE 60334382 D1 DE60334382 D1 DE 60334382D1 DE 60334382 T DE60334382 T DE 60334382T DE 60334382 T DE60334382 T DE 60334382T DE 60334382 D1 DE60334382 D1 DE 60334382D1
- Authority
- DE
- Germany
- Prior art keywords
- cell lysates
- tumor cell
- induced tumor
- lysate
- producing temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013592 cell lysate Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 210000004881 tumor cell Anatomy 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- 239000006166 lysate Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000004443 dendritic cell Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000001338 necrotic effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02018512 | 2002-08-16 | ||
PCT/EP2003/009140 WO2004018659A1 (en) | 2002-08-16 | 2003-08-18 | Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60334382D1 true DE60334382D1 (de) | 2010-11-11 |
Family
ID=31896837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60334382T Expired - Lifetime DE60334382D1 (de) | 2002-08-16 | 2003-08-18 | Verfahren zur herstellung von temperaturinduzierten tumorzell-lysaten zur verwendung als immunogene verbindungen |
Country Status (9)
Country | Link |
---|---|
US (1) | US7595192B2 (de) |
EP (1) | EP1530628B1 (de) |
AT (1) | ATE482720T1 (de) |
AU (1) | AU2003260426A1 (de) |
DE (1) | DE60334382D1 (de) |
DK (1) | DK1530628T3 (de) |
ES (1) | ES2353753T3 (de) |
SI (1) | SI1530628T1 (de) |
WO (1) | WO2004018659A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1530628T1 (sl) | 2002-08-16 | 2011-02-28 | Glycotope Gmbh | Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine |
US8017388B2 (en) | 2003-08-18 | 2011-09-13 | Glycotope Gmbh | Tumour cell lines and uses thereof |
CA2557725C (en) * | 2004-02-13 | 2015-06-30 | Glycotope Gmbh | Highly active glycoproteins-process conditions and an efficient method for their production |
JP5623004B2 (ja) * | 2004-10-25 | 2014-11-12 | ベイラー リサーチ インスティテュートBaylor Research Institute | 熱ショックをかけたメラノーマ細胞体が装填された樹状細胞 |
WO2007001200A1 (fr) * | 2005-06-23 | 2007-01-04 | Obschestvo S Ogranichennoi Otvetsvennostyu 'rusgen' | Cellules dendritiques matures chargees d'un polylysat de tumeurs, et vaccin antitumoral a base desdites cellules |
GB0601598D0 (en) | 2006-01-26 | 2006-03-08 | Stathopoulos Apostolos | Method |
BRPI0716997B8 (pt) | 2006-09-10 | 2021-05-25 | Glycotope Gmbh | proteína ou composição de moléculas de proteína, métodos para produção e uso da mesma |
PL1920781T3 (pl) | 2006-11-10 | 2015-06-30 | Glycotope Gmbh | Kompozycje zawierające core-1-dodatnie mikroorganizmy i ich zastosowanie w leczeniu lub profilaktyce nowotworów |
CL2007002825A1 (es) | 2007-09-28 | 2008-05-30 | Univ De Chile Oncobiomed | Metodo para generar vacunas que estimulen el sistema inmune que comprende inducir celulas mononucleares de sangre periferica a que se diferencien a apc, para luego, separar dichas apc y mezclarlas con adyuvantes; extracto de celulas tumorales; y comp |
EP2281844A1 (de) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC-1-Antikörper |
CA2844543A1 (en) | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms carrying a tumor antigen |
CN109876137A (zh) * | 2012-11-15 | 2019-06-14 | 厦门鹭佳生物科技有限公司 | 一种自体肿瘤疫苗的制备方法及其应用 |
WO2014102220A1 (en) * | 2012-12-28 | 2014-07-03 | Amphera B.V. | Method for preparing an immunogenic lysate, the lysate obtained, dendritic cells loaded with such lysate and a pharmaceutical composition comprising the lysate or the dendritic cells |
CN117815404A (zh) | 2018-05-18 | 2024-04-05 | 第一三共株式会社 | 抗-muc1抗体-药物缀合物 |
CN114466666A (zh) * | 2019-07-22 | 2022-05-10 | 托德·阿拉明 | 细胞治疗和治疗性回输方法 |
WO2024026505A2 (en) * | 2022-07-29 | 2024-02-01 | Amit Patel | Disruption of telocyte activity |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931275A (en) * | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
ATE301201T1 (de) | 1993-06-07 | 2005-08-15 | Vical Inc | Für die gentherapie verwendbare plasmide |
US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
EP0906444A1 (de) | 1996-04-19 | 1999-04-07 | Gabriele Pecher | Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine |
US5948646A (en) | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
JP2003510334A (ja) * | 1999-09-30 | 2003-03-18 | コリクサ コーポレイション | 癌及び感染症の予防及び治療のためのストレスタンパク質組成物及び方法 |
DE10139428A1 (de) | 2001-08-17 | 2003-03-27 | Nemod Immuntherapie Ag | Herstellung und Verwendung von humanen CD124 und CD116 positiven Tumorzelllinien zur Herstellung von allogenen oder semi-allogenen Immuntherapeutika |
SI1529060T1 (sl) | 2002-07-22 | 2015-01-30 | Glycotope Gmbh | Postopek za proizvodnjo imunostimulacijskih mucinov (MUCI) |
SI1530628T1 (sl) | 2002-08-16 | 2011-02-28 | Glycotope Gmbh | Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine |
US8017388B2 (en) * | 2003-08-18 | 2011-09-13 | Glycotope Gmbh | Tumour cell lines and uses thereof |
-
2003
- 2003-08-18 SI SI200331930T patent/SI1530628T1/sl unknown
- 2003-08-18 DE DE60334382T patent/DE60334382D1/de not_active Expired - Lifetime
- 2003-08-18 ES ES03792365T patent/ES2353753T3/es not_active Expired - Lifetime
- 2003-08-18 DK DK03792365.3T patent/DK1530628T3/da active
- 2003-08-18 WO PCT/EP2003/009140 patent/WO2004018659A1/en not_active Application Discontinuation
- 2003-08-18 AU AU2003260426A patent/AU2003260426A1/en not_active Abandoned
- 2003-08-18 AT AT03792365T patent/ATE482720T1/de active
- 2003-08-18 US US10/524,738 patent/US7595192B2/en not_active Expired - Fee Related
- 2003-08-18 EP EP03792365A patent/EP1530628B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK1530628T3 (da) | 2011-01-10 |
US20060127419A1 (en) | 2006-06-15 |
ES2353753T3 (es) | 2011-03-04 |
US7595192B2 (en) | 2009-09-29 |
AU2003260426A1 (en) | 2004-03-11 |
EP1530628A1 (de) | 2005-05-18 |
EP1530628B1 (de) | 2010-09-29 |
WO2004018659A1 (en) | 2004-03-04 |
SI1530628T1 (sl) | 2011-02-28 |
ATE482720T1 (de) | 2010-10-15 |
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