DE60332645D1 - Ii-key/antigene epitop-hybrid-peptid-vakzine - Google Patents

Ii-key/antigene epitop-hybrid-peptid-vakzine

Info

Publication number
DE60332645D1
DE60332645D1 DE60332645T DE60332645T DE60332645D1 DE 60332645 D1 DE60332645 D1 DE 60332645D1 DE 60332645 T DE60332645 T DE 60332645T DE 60332645 T DE60332645 T DE 60332645T DE 60332645 D1 DE60332645 D1 DE 60332645D1
Authority
DE
Germany
Prior art keywords
mhc class
terminal
interest
nucleic acid
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332645T
Other languages
English (en)
Inventor
Robert E Humphreys
Minzhen Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antigen Express Inc
Original Assignee
Antigen Express Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/245,871 external-priority patent/US20030235594A1/en
Application filed by Antigen Express Inc filed Critical Antigen Express Inc
Priority claimed from PCT/US2003/028574 external-priority patent/WO2004030616A2/en
Application granted granted Critical
Publication of DE60332645D1 publication Critical patent/DE60332645D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE60332645T 2002-09-17 2003-09-12 Ii-key/antigene epitop-hybrid-peptid-vakzine Expired - Lifetime DE60332645D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/245,871 US20030235594A1 (en) 1999-09-14 2002-09-17 Ii-Key/antigenic epitope hybrid peptide vaccines
US10/253,286 US7179645B2 (en) 2002-09-24 2002-09-24 Ii-Key/antigenic epitope hybrid peptide vaccines
PCT/US2003/028574 WO2004030616A2 (en) 2002-09-17 2003-09-12 Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES

Publications (1)

Publication Number Publication Date
DE60332645D1 true DE60332645D1 (de) 2010-07-01

Family

ID=31993142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60332645T Expired - Lifetime DE60332645D1 (de) 2002-09-17 2003-09-12 Ii-key/antigene epitop-hybrid-peptid-vakzine

Country Status (3)

Country Link
US (2) US7179645B2 (de)
AT (1) ATE468127T1 (de)
DE (1) DE60332645D1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
WO2006098769A2 (en) * 2004-09-24 2006-09-21 Afg Biosolutions, Inc. Multipathogen and monopathogen protection against the bacterial and viral infections associated with biological warfare, cardiac diseases, and cancers
JP5116150B2 (ja) * 2005-09-07 2013-01-09 日本電気株式会社 Ｈｌａ結合性ペプチド、それをコードするｄｎａ断片および組み換えベクター
US8945573B2 (en) 2005-09-08 2015-02-03 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Targeted identification of immunogenic peptides
CA2812794C (en) * 2005-09-08 2020-02-11 Henry M. Jackson Foundation For The Advancement Of Military Medicine, C. Targeted identification of immunogenic peptides
CA2523032A1 (en) * 2005-10-07 2007-04-07 Immunovaccine Technologies Inc. Vaccines for cancer therapy
DK1957528T3 (da) * 2005-11-30 2012-12-17 Univ Copenhagen Nukleotid-vaccine
US9202184B2 (en) * 2006-09-07 2015-12-01 International Business Machines Corporation Optimizing the selection, verification, and deployment of expert resources in a time of chaos
US8145582B2 (en) * 2006-10-03 2012-03-27 International Business Machines Corporation Synthetic events for real time patient analysis
US8055603B2 (en) * 2006-10-03 2011-11-08 International Business Machines Corporation Automatic generation of new rules for processing synthetic events using computer-based learning processes
US7809660B2 (en) * 2006-10-03 2010-10-05 International Business Machines Corporation System and method to optimize control cohorts using clustering algorithms
US20080294459A1 (en) * 2006-10-03 2008-11-27 International Business Machines Corporation Health Care Derivatives as a Result of Real Time Patient Analytics
EP2629094A1 (de) 2007-01-24 2013-08-21 Carnegie Mellon University Optische Biosensoren
US7970759B2 (en) 2007-02-26 2011-06-28 International Business Machines Corporation System and method for deriving a hierarchical event based database optimized for pharmaceutical analysis
US7792774B2 (en) 2007-02-26 2010-09-07 International Business Machines Corporation System and method for deriving a hierarchical event based database optimized for analysis of chaotic events
US7788203B2 (en) * 2007-02-26 2010-08-31 International Business Machines Corporation System and method of accident investigation for complex situations involving numerous known and unknown factors along with their probabilistic weightings
US7853611B2 (en) 2007-02-26 2010-12-14 International Business Machines Corporation System and method for deriving a hierarchical event based database having action triggers based on inferred probabilities
US20080294361A1 (en) * 2007-05-24 2008-11-27 Popp Shane M Intelligent execution system for the monitoring and execution of vaccine manufacturing
US9498493B2 (en) 2007-09-27 2016-11-22 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
US7930262B2 (en) * 2007-10-18 2011-04-19 International Business Machines Corporation System and method for the longitudinal analysis of education outcomes using cohort life cycles, cluster analytics-based cohort analysis, and probabilistic data schemas
US8426153B2 (en) * 2007-12-03 2013-04-23 Carnegie Mellon University Linked peptides fluorogenic biosensors
US7779051B2 (en) * 2008-01-02 2010-08-17 International Business Machines Corporation System and method for optimizing federated and ETL'd databases with considerations of specialized data structures within an environment having multidimensional constraints
MX2010007530A (es) * 2008-01-10 2010-11-10 Res Dev Foundation Vacunas y diagnosticos para ehrlichiosis.
AU2009253780B2 (en) 2008-06-05 2014-08-14 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
US8748130B2 (en) * 2008-09-02 2014-06-10 Antigen Express, Inc. Human papillomavirus / Ii-Key hybrids and methods of use
EP3552622A3 (de) * 2008-11-21 2019-12-04 Københavns Universitet (University Of Copenhagen) Priming einer immunantwort
US20100310591A1 (en) * 2009-01-28 2010-12-09 Robert Humphreys Ii-KEY HYBRID PEPTIDES THAT MODULATE THE IMMUNE RESPONSE TO INFLUENZA
US8187611B2 (en) * 2009-10-29 2012-05-29 Albert Einstein College Of Medicine Of Yeshiva University Anti-peptide antibodies that cross react with protective antigen of Bacillus anthracis and uses thereof
AU2011230619C1 (en) 2010-03-25 2016-06-23 Oregon Health & Science University CMV glycoproteins and recombinant vectors
US10318877B2 (en) 2010-10-19 2019-06-11 International Business Machines Corporation Cohort-based prediction of a future event
RS57397B8 (sr) 2011-06-10 2020-01-31 Univ Oregon Health & Science Cmv glikoproteini i rekombinantni vektori
EP2568289A3 (de) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunselektion von rekombinantem vesikulärem Stomatitisvirus mit Expression von HIV-1-Proteinen durch Breitbandneutralisierungs-Antikörper
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
PL3262932T3 (pl) * 2011-10-28 2019-10-31 Regeneron Pharma Genetycznie zmodyfikowany główny układ zgodności tkankowej myszy
EP2679596B1 (de) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 Env-proteinvariante
JP6608282B2 (ja) * 2012-10-30 2019-11-20 アラヴァックス ピーティーワイ リミテッド 新規免疫療法用分子およびその使用
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
BR112016006813A2 (pt) 2013-09-25 2017-09-19 Aravax Pty Ltd Composição imunoterapêutica nova e seus usos
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
CN105753989A (zh) * 2014-12-15 2016-07-13 牛津疫苗医学生物科技（英国）有限公司 人工多抗原融合蛋白及其制备和应用
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3072901A1 (de) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Lösliche hiv-1-hüllglykoproteintrimere
WO2016183500A1 (en) * 2015-05-14 2016-11-17 La Jolla Institute For Allergy And Immunology Novel antigens and t cell epitopes from cockroach and methods of making and using same
GB201704417D0 (en) 2017-03-20 2017-05-03 Univ Copenhagen Improved li vaccine adjuvant
CN114010777B (zh) * 2021-08-31 2022-07-22 王树毅 一种多佐剂制备多组分疫苗的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
DE3586772T2 (de) 1984-07-24 1993-03-04 Coselco Mimotopes Pty Ltd Verfahren zur bestimmung von mimotopen.
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US6133029A (en) 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US5194425A (en) 1988-06-23 1993-03-16 Anergen, Inc. Mhc-mediated toxic conjugates useful in ameliorating autoimmunity
CA2047191A1 (en) 1989-02-17 1990-08-18 Hendrik M. Geysen Method for the use and synthesis of peptides
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5126132A (en) 1989-08-21 1992-06-30 The United States Of America As Represented By The Department Of Health And Human Services Tumor infiltrating lymphocytes as a treatment modality for human cancer
JP3203599B2 (ja) 1989-10-24 2001-08-27 カイロン コーポレイション 感染性タンパク質デリバリーシステム
US6120769A (en) 1989-11-03 2000-09-19 Immulogic Pharmaceutical Corporation Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
US5747334A (en) 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
CA2090860C (en) 1990-11-21 2003-09-16 Richard A. Houghten Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US6419931B1 (en) * 1991-08-26 2002-07-16 Epimmune Inc. Compositions and methods for eliciting CTL immunity
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
JPH07501942A (ja) 1991-11-29 1995-03-02 カイロン　コーポレイション 抗ガン免疫療法用ベクター構成体
US5679527A (en) 1992-03-25 1997-10-21 Antigen Express, Inc. Modification of polypeptide structure
EP0671926B1 (de) * 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunmodulierende peptide
AU5670194A (en) 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US5559028A (en) 1993-05-19 1996-09-24 Antigen Express, Inc. Methods of enhancing or antigen presentation to T cells inhibiting
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
ATE243230T1 (de) 1995-11-01 2003-07-15 Bracco Research Sa Gelierte magnetisch markierte molekularsysteme als nmr-bilderzeugungsmittel
WO1997049430A1 (en) 1996-06-26 1997-12-31 Antigen Express, Inc. Immunotherapy by modulation of antigen presentation
US6432409B1 (en) 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response

Also Published As

Publication number Publication date
ATE468127T1 (de) 2010-06-15
US7179645B2 (en) 2007-02-20
US20080305122A1 (en) 2008-12-11
US20040058881A1 (en) 2004-03-25

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