DE60329126D1 - Konjugate mit biologisch abbaubarem polymer und verwendung dafür - Google Patents
Konjugate mit biologisch abbaubarem polymer und verwendung dafürInfo
- Publication number
- DE60329126D1 DE60329126D1 DE60329126T DE60329126T DE60329126D1 DE 60329126 D1 DE60329126 D1 DE 60329126D1 DE 60329126 T DE60329126 T DE 60329126T DE 60329126 T DE60329126 T DE 60329126T DE 60329126 D1 DE60329126 D1 DE 60329126D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- polymer
- biodegradable polymer
- apyrase
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Biological Depolymerization Polymers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35830302P | 2002-02-20 | 2002-02-20 | |
| PCT/US2003/004845 WO2003070823A2 (en) | 2002-02-20 | 2003-02-19 | Conjugates comprising a biodegradable polymer and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60329126D1 true DE60329126D1 (de) | 2009-10-15 |
Family
ID=27757725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60329126T Expired - Lifetime DE60329126D1 (de) | 2002-02-20 | 2003-02-19 | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7785618B2 (de) |
| EP (2) | EP2138575B8 (de) |
| AT (1) | ATE441706T1 (de) |
| AU (1) | AU2003219796A1 (de) |
| DE (1) | DE60329126D1 (de) |
| WO (1) | WO2003070823A2 (de) |
Families Citing this family (90)
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| US7838619B2 (en) * | 2002-01-14 | 2010-11-23 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| AU2003219796A1 (en) * | 2002-02-20 | 2003-09-09 | Beth Israel Deaconess Medical Center | Conjugates comprising a biodegradable polymer and uses therefor |
| AU2003254023A1 (en) | 2002-07-19 | 2004-02-09 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
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| WO2006108052A2 (en) * | 2005-04-06 | 2006-10-12 | Genzyme Corporation | Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting |
| EP1933881B1 (de) | 2005-09-22 | 2019-03-13 | Medivas, LLC | Feste polymer-abgabezusammensetzungen und anwendungsverfahren dafür |
| EP1926780B1 (de) | 2005-09-22 | 2013-08-14 | Medivas, LLC | Bis-( -amino)-diol-diester-haltige poly(esteramid) und poly(esterurethan)-zusammensetzungen und verwendungsverfahren |
| DE102006046411A1 (de) * | 2006-09-20 | 2008-03-27 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von akutem Lungenversagen (ALI) |
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| WO2010108657A2 (en) | 2009-03-23 | 2010-09-30 | Noxxon Pharma Ag | C5a binding nucleic acids and the use thereof |
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| JP2014503187A (ja) | 2010-10-29 | 2014-02-13 | ノクソン ファーマ エージー | 身体からヘプシジンを除去するためのヘプシジン結合核酸の使用 |
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| MX368966B (es) * | 2011-06-10 | 2019-10-23 | Mersana Therapeutics Inc | Conjugados de proteina-polimero-farmaco. |
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| JP3158758B2 (ja) * | 1993-02-19 | 2001-04-23 | 松下電器産業株式会社 | 端末アダプタ装置とデータ伝送方法 |
| US6179817B1 (en) | 1995-02-22 | 2001-01-30 | Boston Scientific Corporation | Hybrid coating for medical devices |
| EP0815252A1 (de) | 1995-03-24 | 1998-01-07 | Novartis AG | Gentherapie für transplantation und entzündliche oder thrombotische zustände |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| WO1996040792A1 (en) * | 1995-06-07 | 1996-12-19 | Novo Nordisk A/S | Modification of polypeptides |
| US6312921B1 (en) | 1996-07-26 | 2001-11-06 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6248327B1 (en) | 1998-09-11 | 2001-06-19 | Vanderbilt University | Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis |
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| US6822086B1 (en) | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| US7838619B2 (en) * | 2002-01-14 | 2010-11-23 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| AU2003219796A1 (en) * | 2002-02-20 | 2003-09-09 | Beth Israel Deaconess Medical Center | Conjugates comprising a biodegradable polymer and uses therefor |
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| US20040205840A1 (en) * | 2003-04-11 | 2004-10-14 | Pioneer Hi-Bred International, Inc. | Method for reducing gene expression |
-
2003
- 2003-02-19 AU AU2003219796A patent/AU2003219796A1/en not_active Abandoned
- 2003-02-19 EP EP09011078.4A patent/EP2138575B8/de not_active Expired - Lifetime
- 2003-02-19 WO PCT/US2003/004845 patent/WO2003070823A2/en not_active Application Discontinuation
- 2003-02-19 DE DE60329126T patent/DE60329126D1/de not_active Expired - Lifetime
- 2003-02-19 AT AT03716070T patent/ATE441706T1/de not_active IP Right Cessation
- 2003-02-19 EP EP03716070A patent/EP1585817B1/de not_active Expired - Lifetime
-
2004
- 2004-08-20 US US10/922,378 patent/US7785618B2/en not_active Expired - Fee Related
-
2010
- 2010-08-27 US US12/870,030 patent/US20110044967A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050169968A1 (en) | 2005-08-04 |
| AU2003219796A8 (en) | 2003-09-09 |
| EP2138575B1 (de) | 2013-06-19 |
| ATE441706T1 (de) | 2009-09-15 |
| EP2138575A1 (de) | 2009-12-30 |
| EP2138575B8 (de) | 2013-07-24 |
| US7785618B2 (en) | 2010-08-31 |
| WO2003070823A9 (en) | 2005-06-02 |
| EP1585817A4 (de) | 2005-12-28 |
| AU2003219796A1 (en) | 2003-09-09 |
| WO2003070823A3 (en) | 2004-08-26 |
| US20110044967A1 (en) | 2011-02-24 |
| WO2003070823A2 (en) | 2003-08-28 |
| EP1585817B1 (de) | 2009-09-02 |
| EP1585817A2 (de) | 2005-10-19 |
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