DE60325965D1 - Für die behandlung bzw. prevention von schmerzen geeignete triazaspiroverbindungen - Google Patents
Für die behandlung bzw. prevention von schmerzen geeignete triazaspiroverbindungenInfo
- Publication number
- DE60325965D1 DE60325965D1 DE60325965T DE60325965T DE60325965D1 DE 60325965 D1 DE60325965 D1 DE 60325965D1 DE 60325965 T DE60325965 T DE 60325965T DE 60325965 T DE60325965 T DE 60325965T DE 60325965 D1 DE60325965 D1 DE 60325965D1
- Authority
- DE
- Germany
- Prior art keywords
- bzw
- prevention
- triazaspiro
- treatment
- pain related
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38480702P | 2002-05-31 | 2002-05-31 | |
US46021903P | 2003-04-03 | 2003-04-03 | |
US10/448,627 US6995168B2 (en) | 2002-05-31 | 2003-05-29 | Triazaspiro compounds useful for treating or preventing pain |
PCT/US2003/017419 WO2003101953A2 (en) | 2002-05-31 | 2003-06-02 | Triazaspiro compounds useful for treating or preventing pain |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325965D1 true DE60325965D1 (de) | 2009-03-12 |
Family
ID=29716134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325965T Expired - Lifetime DE60325965D1 (de) | 2002-05-31 | 2003-06-02 | Für die behandlung bzw. prevention von schmerzen geeignete triazaspiroverbindungen |
Country Status (12)
Country | Link |
---|---|
US (2) | US6995168B2 (de) |
EP (1) | EP1509523B1 (de) |
JP (2) | JP4658595B2 (de) |
AT (1) | ATE421517T1 (de) |
AU (1) | AU2003273250A1 (de) |
CY (1) | CY1109031T1 (de) |
DE (1) | DE60325965D1 (de) |
DK (1) | DK1509523T3 (de) |
ES (1) | ES2320750T3 (de) |
PT (1) | PT1509523E (de) |
SI (1) | SI1509523T1 (de) |
WO (1) | WO2003101953A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995168B2 (en) * | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
KR101204247B1 (ko) | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1h-피라졸 화합물 및 그의 시클린 의존성키나제 (cdk) 및 글리코겐 합성효소 키나제-3(gsk-3) 조정제로서 용도 |
JP5475235B2 (ja) * | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
DE102005038141A1 (de) * | 2005-08-12 | 2007-02-15 | Grünenthal GmbH | Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate |
UA107943C2 (en) * | 2009-11-16 | 2015-03-10 | Lilly Co Eli | Compounds of spiropiperidines as antagonists of the orl-1 receptors |
WO2014102590A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
CN103242230B (zh) * | 2013-05-02 | 2015-02-18 | 陕西步长高新制药有限公司 | 一种喹啉酮衍生物及其制备方法 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3161644A (en) | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
US3155670A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes |
US3155669A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 2, 4, 8-triaza-spiro (4, 5) dec-2-enes |
US3238216A (en) * | 1963-06-20 | 1966-03-01 | Res Lab Dr C Janssen N V | Substituted 1, 3, 8-triaza-spiro (4, 5) decanes |
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
US4374245A (en) | 1982-04-09 | 1983-02-15 | Hoechst-Roussel Pharmaceuticals Inc. | 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
US4418067A (en) | 1982-04-09 | 1983-11-29 | Hoechst-Roussel Pharmaceuticals Inc. | 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]dec.5)decan-4-one to treat pain |
US4409230A (en) | 1982-04-09 | 1983-10-11 | Hoechst-Roussel Pharmaceuticals Inc. | Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
DE4135473A1 (de) | 1991-10-28 | 1993-04-29 | Bayer Ag | Triazaspirodecanon-methylchromane |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
US5789402A (en) | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
US5739336A (en) | 1995-06-23 | 1998-04-14 | Syntex (U.S.A.) Inc. | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives |
GB9521781D0 (en) | 1995-10-24 | 1996-01-03 | Merck Sharp & Dohme | Therapeutic agents |
CA2226058C (en) | 1997-01-30 | 2008-01-29 | F. Hoffmann-La Roche Ag | 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives |
EP0921125B1 (de) | 1997-12-05 | 2002-01-30 | F. Hoffmann-La Roche Ag | 1,3,8-Triazaspiro[4,5]decan-4-on-derivate |
CN1291984A (zh) | 1998-03-06 | 2001-04-18 | 詹森药业有限公司 | 甘氨酸传输抑制剂 |
US6277991B1 (en) | 1998-05-18 | 2001-08-21 | Novo Nordisk A/S | 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes |
JP2002515503A (ja) * | 1998-05-18 | 2002-05-28 | ノボ ノルディスク アクティーゼルスカブ | オピオイド受容体のサブタイプへの高い親和性を有する新規1,3,8−トリアザスピロ〔4,5〕デカノン |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
CA2324330A1 (en) | 1999-11-08 | 2001-05-08 | Ssp Co., Ltd. | 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same |
WO2001036418A1 (en) | 1999-11-17 | 2001-05-25 | Novo Nordisk A/S | Novel triazaspirodecanones with high affinity for opioid receptor subtypes |
EP1537110B1 (de) | 1999-12-06 | 2007-01-17 | Euro-Celtique, S.A. | Triazospiroverbindungen mit nociceptin-rezeptoraffinität |
CA2404280A1 (en) * | 2000-03-24 | 2002-09-23 | Meiji Seika Kaisha, Ltd. | Diphenylalkylamine derivatives useful as opioid .delta. receptor agonists |
US6995168B2 (en) * | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
-
2003
- 2003-05-29 US US10/448,627 patent/US6995168B2/en not_active Expired - Lifetime
- 2003-06-02 SI SI200331540T patent/SI1509523T1/sl unknown
- 2003-06-02 PT PT03741857T patent/PT1509523E/pt unknown
- 2003-06-02 ES ES03741857T patent/ES2320750T3/es not_active Expired - Lifetime
- 2003-06-02 WO PCT/US2003/017419 patent/WO2003101953A2/en active Application Filing
- 2003-06-02 AU AU2003273250A patent/AU2003273250A1/en not_active Abandoned
- 2003-06-02 JP JP2004509647A patent/JP4658595B2/ja not_active Expired - Fee Related
- 2003-06-02 AT AT03741857T patent/ATE421517T1/de active
- 2003-06-02 EP EP03741857A patent/EP1509523B1/de not_active Expired - Lifetime
- 2003-06-02 DK DK03741857T patent/DK1509523T3/da active
- 2003-06-02 DE DE60325965T patent/DE60325965D1/de not_active Expired - Lifetime
-
2005
- 2005-06-16 US US11/155,263 patent/US7414062B2/en not_active Expired - Lifetime
-
2009
- 2009-04-10 CY CY20091100427T patent/CY1109031T1/el unknown
-
2010
- 2010-08-31 JP JP2010194855A patent/JP2011021021A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1509523A4 (de) | 2006-04-05 |
EP1509523A2 (de) | 2005-03-02 |
AU2003273250A8 (en) | 2003-12-19 |
WO2003101953A2 (en) | 2003-12-11 |
JP4658595B2 (ja) | 2011-03-23 |
DK1509523T3 (da) | 2009-04-27 |
US20050009854A1 (en) | 2005-01-13 |
WO2003101953A3 (en) | 2004-08-05 |
JP2011021021A (ja) | 2011-02-03 |
SI1509523T1 (sl) | 2009-06-30 |
PT1509523E (pt) | 2009-04-20 |
US6995168B2 (en) | 2006-02-07 |
JP2006516239A (ja) | 2006-06-29 |
US20050234084A1 (en) | 2005-10-20 |
AU2003273250A1 (en) | 2003-12-19 |
CY1109031T1 (el) | 2014-07-02 |
ATE421517T1 (de) | 2009-02-15 |
US7414062B2 (en) | 2008-08-19 |
ES2320750T3 (es) | 2009-05-28 |
EP1509523B1 (de) | 2009-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |