DE60319877D1 - Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer - Google Patents

Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer

Info

Publication number
DE60319877D1
DE60319877D1 DE60319877T DE60319877T DE60319877D1 DE 60319877 D1 DE60319877 D1 DE 60319877D1 DE 60319877 T DE60319877 T DE 60319877T DE 60319877 T DE60319877 T DE 60319877T DE 60319877 D1 DE60319877 D1 DE 60319877D1
Authority
DE
Germany
Prior art keywords
hemmer
hmg
dosage form
coa reductase
form containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE60319877T
Other languages
English (en)
Other versions
DE60319877T2 (de
Inventor
Dwayne Thomas Bend Friesen
Bend Lorenz
Bend Lyon
Bruno C Hancock
T J Mcdermott
Ravi M Shanker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32682223&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60319877(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Application granted granted Critical
Publication of DE60319877D1 publication Critical patent/DE60319877D1/de
Publication of DE60319877T2 publication Critical patent/DE60319877T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60319877T 2002-12-20 2003-12-12 Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer Revoked DE60319877T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43534502P 2002-12-20 2002-12-20
US435345P 2002-12-20
PCT/IB2003/006087 WO2004056359A1 (en) 2002-12-20 2003-12-12 Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor

Publications (2)

Publication Number Publication Date
DE60319877D1 true DE60319877D1 (de) 2008-04-30
DE60319877T2 DE60319877T2 (de) 2009-04-30

Family

ID=32682223

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319877T Revoked DE60319877T2 (de) 2002-12-20 2003-12-12 Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer

Country Status (24)

Country Link
US (1) US7897175B2 (de)
EP (1) EP1581210B1 (de)
JP (1) JP2006512359A (de)
KR (1) KR20050088190A (de)
CN (1) CN1728995A (de)
AR (1) AR042534A1 (de)
AT (1) ATE389396T1 (de)
AU (1) AU2003286372A1 (de)
BR (1) BR0317593A (de)
CA (1) CA2509688A1 (de)
CO (1) CO5590898A2 (de)
DE (1) DE60319877T2 (de)
ES (1) ES2300628T3 (de)
GT (1) GT200300295A (de)
IL (1) IL169090A0 (de)
NL (1) NL1025070C (de)
NO (1) NO20052779L (de)
PE (1) PE20040970A1 (de)
PL (1) PL377606A1 (de)
RU (1) RU2005119176A (de)
TW (1) TW200420301A (de)
UY (1) UY28134A1 (de)
WO (1) WO2004056359A1 (de)
ZA (1) ZA200504123B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
CA2455288A1 (en) * 2001-06-21 2003-01-03 Pfizer Products Inc. Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors
CA2450748A1 (en) * 2001-06-22 2003-01-03 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
BRPI0516772A (pt) * 2004-10-25 2008-09-23 Japan Tobacco Inc formulação sólida com solubilidade e estabilidade melhoradas e método para produção da referida formulação
AP2007003979A0 (en) * 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
WO2006085217A2 (en) * 2005-02-08 2006-08-17 Pfizer Products Inc. Solid adsorbates of hydrophobic drugs
US7737155B2 (en) 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US8828438B2 (en) 2005-05-31 2014-09-09 Bend Research, Inc. Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors and HMG-CoA reductase
CA2618255C (en) 2005-08-08 2015-05-26 Abbott Gmbh & Co. Kg Itraconazole compositions with improved bioavailability
JP2009504590A (ja) * 2005-08-08 2009-02-05 アボット ゲーエムベーハー ウント コンパニー カーゲー 改善された生物学的利用能をもつ剤型
DE102005049293A1 (de) * 2005-10-15 2007-04-26 Bayer Healthcare Ag Kombinationspräparate von Salzen oder o-Acetylsalicylsäure
US7351853B2 (en) * 2006-01-23 2008-04-01 Albion Advanced Nutrition Method of manufacturing a granular mineral composition
KR100791256B1 (ko) * 2006-03-17 2008-01-03 주식회사 대웅제약 약학적으로 유용하고 안정한 아토바스타틴 고체분산체 및이를 포함하는 조성물
US20070269503A1 (en) * 2006-05-16 2007-11-22 James Walter Burgess Combinations of HMG CoA reductase inhibitors and negatively charged phospholipids and uses thereof
AU2007300071A1 (en) * 2006-09-27 2008-04-03 Dr. Reddy's Laboratories Ltd. Atorvastatin pharmaceutical compositions
WO2008065506A2 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Pharmaceutical compositions comprising nanoparticles comprising enteric polymers and casein
AR071706A1 (es) * 2008-05-15 2010-07-07 Otsuka Pharma Co Ltd Una formulacion farmaceutica de cilostazol solida de liberacion sostenida y metodo de preparacion.
EP2379547A1 (de) 2008-12-16 2011-10-26 Schering Corporation Pyridopyrimidinderivate und verfahren zu deren anwendung
WO2010075069A1 (en) 2008-12-16 2010-07-01 Schering Corporation Bicyclic pyranone derivatives as nicotinic acid receptor agonists
US8877221B2 (en) 2010-10-27 2014-11-04 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same
US9107983B2 (en) 2010-10-27 2015-08-18 Warsaw Orthopedic, Inc. Osteoconductive matrices comprising statins
CN103200935A (zh) 2010-11-04 2013-07-10 霍夫曼-拉罗奇有限公司 包含2-甲基丙硫代酸s-[2-([[1-(2-乙基丁基)-环己基]-羰基]氨基)苯基]酯和交联羧甲基纤维素钠的组合物
KR101298788B1 (ko) * 2011-03-15 2013-08-22 보령제약 주식회사 안정성이 개선된 복합제제
WO2012170417A2 (en) 2011-06-06 2012-12-13 Warsaw Orthopedic, Inc. Methods and compositions to enhance bone growth comprising a statin
US8313774B1 (en) 2012-06-26 2012-11-20 Magnifica Inc. Oral solid composition
MA40590A (fr) * 2014-08-28 2017-07-05 Dezima Pharma B V Composition pharmaceutique et combinaison thérapeutique comprenant un inhibiteur de protéine de transfert d'ester de cholestéryle et des inhibiteurs de hmg-coa réductase
JP2019131472A (ja) * 2016-05-31 2019-08-08 興和株式会社 医薬組成物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180589A (en) 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
EP0680320B1 (de) 1993-01-19 1999-04-14 Warner-Lambert Company Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren
DK0828495T3 (da) 1995-06-01 2003-02-24 Searle & Co Misoprostolholdige faste stabiliserede dispersioner
DE19627431A1 (de) 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
ATE250929T1 (de) * 1997-05-30 2003-10-15 Osmotica Corp Mehrlagige osmosevorrichtung
US6235311B1 (en) 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
US6147089A (en) * 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
SI20109A (sl) * 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
AU2157400A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
EP1970052A2 (de) * 1999-02-09 2008-09-17 Pfizer Products Inc. Zusammensetzungen basischer Arzneistoffe mit verbesserter Bioverfügbarkeit
EP1027888B1 (de) * 1999-02-10 2009-06-10 Pfizer Products Inc. Osmotisches System zur Verabreichung von Wirkstoffen, die feste amorphe Dispersionen enthalten
WO2001093860A1 (en) * 2000-06-09 2001-12-13 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US6620821B2 (en) * 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
HUP0303083A3 (en) * 2000-08-15 2005-05-30 Pfizer Prod Inc Pharmaceutical compositions containing therapeutic combination of a cetp inhibitor and atorvastatin and their use
US20020077348A1 (en) 2000-11-21 2002-06-20 Dean Herbert M. Dosage unit for cardioprotection
US20040235935A1 (en) * 2001-06-12 2004-11-25 Francis Vanderbist Oral pharmaceutical composition containing a statin derivative
US20040053842A1 (en) * 2002-07-02 2004-03-18 Pfizer Inc. Methods of treatment with CETP inhibitors and antihypertensive agents
CA2508840A1 (en) 2002-12-20 2004-07-08 Pfizer Products Inc. Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor
US20040132771A1 (en) 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors

Also Published As

Publication number Publication date
KR20050088190A (ko) 2005-09-02
UY28134A1 (es) 2004-07-30
WO2004056359A1 (en) 2004-07-08
CO5590898A2 (es) 2005-12-30
AU2003286372A1 (en) 2004-07-14
NL1025070C (nl) 2010-04-06
DE60319877T2 (de) 2009-04-30
BR0317593A (pt) 2005-11-22
CN1728995A (zh) 2006-02-01
NO20052779D0 (no) 2005-06-08
IL169090A0 (en) 2007-07-04
JP2006512359A (ja) 2006-04-13
PL377606A1 (pl) 2006-02-06
CA2509688A1 (en) 2004-07-08
ATE389396T1 (de) 2008-04-15
ES2300628T3 (es) 2008-06-16
RU2005119176A (ru) 2006-01-20
NO20052779L (no) 2005-08-25
US7897175B2 (en) 2011-03-01
US20040197398A1 (en) 2004-10-07
PE20040970A1 (es) 2004-12-14
EP1581210A1 (de) 2005-10-05
NL1025070A1 (nl) 2004-06-22
AR042534A1 (es) 2005-06-22
TW200420301A (en) 2004-10-16
EP1581210B1 (de) 2008-03-19
ZA200504123B (en) 2006-02-22
GT200300295A (es) 2004-08-18

Similar Documents

Publication Publication Date Title
DE60319877D1 (de) Dosierungsform enthaltend einen cetp-hemmer und einen hmg-coa reduktase hemmer
DK1373259T3 (da) Pyridazinonaldosereduktaseinhibitorer
DK1223918T3 (da) Farmaceutiske præparater omfattende en HMG-CoA-reductaseinhibitor
ATE443048T1 (de) 4-oxochinolinverbindungen und deren verwendung als hiv-integrase-inhibitoren
DE60204612D1 (de) Metallkoordinationsverbindung, Lumineszente Vorrichtung und Bildanzeigevorrichtung
DE60138597D1 (de) Lumineszente Vorrichtung und dafür verwendete Metallkoordinationsverbindung
IL165249A0 (en) Hapten-carrier conjugates and uses thereof
IS7362A (is) Kínasólín efnasambönd
AU2003301662A8 (en) Quinazolinones and derivatives thereof as factor xa inhibitors
AP2004003189A0 (en) Use of CETP inhibitors and optionally HMG COA reductase inhibitors and/or antihypertensive agents.
DE50303193D1 (de) Übertrager
IL163929A0 (en) Combination comprising an hmg-coa reductase inhibitor and an insulin secretor enhancer or an insulinsensitizer
HK1080734A1 (en) Combination therapy comprising a bisphosphonate and a hmg-coa reductase inhibitor
PL374364A1 (en) Use of cetp inhibitors and antihypertensive agents as well as optionally hmg coa reductase inhibitors
DE50313157D1 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
DE50305140D1 (de) Zerstäubungsanordnung
ATE295844T1 (de) Verbindungen und ihre verwendung als hemmer des glycintransports
DE60102537D1 (de) Acryl ester verbindung und ihre verwendung
DE50313548D1 (de) Zerstäubungsanordnung
HUP0303589A3 (en) Combination of a taxane and a cyclin-dependent kinase inhibitor
NO20034310D0 (no) Forfalskningsdetektor
EP1703911A4 (de) Kombinationstherapien unter verwendung einer zusammensetzung mit einem hmg-coa-reduktase-inhibitor und einer vitamin b6-verwandten verbindung
ITMI20022484A1 (it) Sorgente elettronica piroelettrica
GB0001565D0 (en) Dihydrofolate reductase inhibitors
ATE292314T1 (de) Münzbehälter

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: FRIESEN, DWAYNE THOMAS, BEND, OREG., US

Inventor name: LORENZ, DOUGLAS ALAN, BEND, OREG., US

Inventor name: LYON, DAVID KEITH, BEND, OREG., US

Inventor name: HANCOCK, BRUNO C., GROTON, CONN., US

Inventor name: MCDERMOTT, T. J., GROTON, CONN., US

Inventor name: SHANKER, RAVI M., GROTON, CONN., US

8363 Opposition against the patent
8331 Complete revocation