DE60318320D1 - Benzimidazolone und ihre verwendung als cytokininhibitoren - Google Patents

Benzimidazolone und ihre verwendung als cytokininhibitoren

Info

Publication number
DE60318320D1
DE60318320D1 DE60318320T DE60318320T DE60318320D1 DE 60318320 D1 DE60318320 D1 DE 60318320D1 DE 60318320 T DE60318320 T DE 60318320T DE 60318320 T DE60318320 T DE 60318320T DE 60318320 D1 DE60318320 D1 DE 60318320D1
Authority
DE
Germany
Prior art keywords
sub
compounds
benzimidazolone
hibitors
cytokinin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60318320T
Other languages
English (en)
Other versions
DE60318320T2 (de
Inventor
Antonio J M Barbosa
Daniel R Goldberg
Abdelhakim Hammach
Pingrong Liu
Neil Moss
Mark Stephen Ralph
Gregory Paul Roth
Christopher Ronald Sarko
Fariba Soleymanzadeh
Andre White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Publication of DE60318320D1 publication Critical patent/DE60318320D1/de
Application granted granted Critical
Publication of DE60318320T2 publication Critical patent/DE60318320T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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DE60318320T 2002-09-13 2003-09-04 Benzimidazolone und ihre verwendung als cytokininhibitoren Expired - Lifetime DE60318320T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41042002P 2002-09-13 2002-09-13
US410420P 2002-09-13
PCT/US2003/027692 WO2004024699A1 (en) 2002-09-13 2003-09-04 Benzimidazolones and their use as cytokine inhibitors

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DE60318320D1 true DE60318320D1 (de) 2008-02-07
DE60318320T2 DE60318320T2 (de) 2008-12-11

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US (1) US7115644B2 (de)
EP (1) EP1539708B1 (de)
JP (1) JP4551765B2 (de)
AT (1) ATE382039T1 (de)
AU (1) AU2003265924A1 (de)
CA (1) CA2498754C (de)
DE (1) DE60318320T2 (de)
ES (1) ES2297265T3 (de)
WO (1) WO2004024699A1 (de)

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WO2011021678A1 (ja) * 2009-08-21 2011-02-24 武田薬品工業株式会社 縮合複素環化合物
US9550737B2 (en) * 2012-06-11 2017-01-24 Ucb Biopharma Sprl TNF -α modulating benzimidazoles
US8901304B1 (en) 2013-11-05 2014-12-02 King Fahd University Of Petroleum And Minerals Benzo[D]imidazole derivatives of piperidine and piperazine
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10532986B2 (en) * 2016-08-22 2020-01-14 Medshine Discovery Inc. Cyclic compound acting as PDE4 inhibitor
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

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CA2498754A1 (en) 2004-03-25
ATE382039T1 (de) 2008-01-15
EP1539708A1 (de) 2005-06-15
US7115644B2 (en) 2006-10-03
AU2003265924A1 (en) 2004-04-30
EP1539708B1 (de) 2007-12-26
US20040192748A1 (en) 2004-09-30
WO2004024699A1 (en) 2004-03-25
CA2498754C (en) 2012-03-06
JP4551765B2 (ja) 2010-09-29

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