DE60313786D1 - Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 - Google Patents
Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4Info
- Publication number
- DE60313786D1 DE60313786D1 DE60313786T DE60313786T DE60313786D1 DE 60313786 D1 DE60313786 D1 DE 60313786D1 DE 60313786 T DE60313786 T DE 60313786T DE 60313786 T DE60313786 T DE 60313786T DE 60313786 D1 DE60313786 D1 DE 60313786D1
- Authority
- DE
- Germany
- Prior art keywords
- growth factor
- binding protein
- factor binding
- insulinary
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02021844 | 2002-09-27 | ||
EP02021844 | 2002-09-27 | ||
PCT/EP2003/010658 WO2004028568A1 (en) | 2002-09-27 | 2003-09-25 | Conjugates of insulin-like growth factor binding protein-4 and poly (ethylene glycol) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60313786D1 true DE60313786D1 (de) | 2007-06-21 |
DE60313786T2 DE60313786T2 (de) | 2008-01-24 |
Family
ID=32039114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60313786T Expired - Lifetime DE60313786T2 (de) | 2002-09-27 | 2003-09-25 | Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20060100144A1 (de) |
EP (1) | EP1545623B1 (de) |
JP (1) | JP4237703B2 (de) |
AT (1) | ATE361761T1 (de) |
AU (1) | AU2003285286A1 (de) |
CA (1) | CA2498062C (de) |
DE (1) | DE60313786T2 (de) |
ES (1) | ES2285215T3 (de) |
WO (1) | WO2004028568A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006034832A2 (en) * | 2004-09-27 | 2006-04-06 | Univ Muenchen L Maximilians | Use of igfbp-2 in senescence diseases and for the maintenance of organ functions |
WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
US8034792B2 (en) * | 2007-09-11 | 2011-10-11 | University Of Massachusetts | Insulin-like growth factor binding protein 7 for treatment of cancer |
JP5758888B2 (ja) | 2009-07-06 | 2015-08-05 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二重特異性ジゴキシゲニン結合抗体 |
WO2011056799A1 (en) * | 2009-11-05 | 2011-05-12 | Sangart, Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
RU2013135175A (ru) | 2011-01-03 | 2015-02-10 | Ф. Хоффманн-Ля Рош Аг | Фармацевтическая композиция комплекса антитела против дигоксигенина и дигоксигенина, конъюгированного с пептидом |
WO2013040504A2 (en) | 2011-09-14 | 2013-03-21 | University Of Massachusetts | Srpx for treatment of cancer |
MX2017002140A (es) * | 2014-08-19 | 2017-08-21 | Biogen Ma Inc | Metodo de pegilacion. |
US10046058B2 (en) | 2014-12-02 | 2018-08-14 | Rezolute, Inc. | Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates |
CN107708679A (zh) | 2015-06-04 | 2018-02-16 | 安特里阿比奥有限公司 | 用于制备位点特异性蛋白质偶联物的胺聚乙二醇化方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004775A (en) * | 1990-08-03 | 1999-12-21 | The Salk Institute For Biological Studies | DNA encoding IGFBP-4 |
US5212074A (en) * | 1990-08-28 | 1993-05-18 | Chiron Corporation | Genetic material encoding new insulin-like growth factor binding protein igfbp-6 |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
US6207640B1 (en) * | 1994-04-07 | 2001-03-27 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US6841386B2 (en) * | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
JP2005508295A (ja) * | 2001-06-07 | 2005-03-31 | エフ.ホフマン−ラ ロシュ アーゲー | Igf結合タンパク質の変異体、およびそれらのアゴニストの作製法 |
-
2003
- 2003-09-25 CA CA2498062A patent/CA2498062C/en not_active Expired - Fee Related
- 2003-09-25 WO PCT/EP2003/010658 patent/WO2004028568A1/en active IP Right Grant
- 2003-09-25 EP EP03778269A patent/EP1545623B1/de not_active Expired - Lifetime
- 2003-09-25 JP JP2004539015A patent/JP4237703B2/ja not_active Expired - Fee Related
- 2003-09-25 DE DE60313786T patent/DE60313786T2/de not_active Expired - Lifetime
- 2003-09-25 ES ES03778269T patent/ES2285215T3/es not_active Expired - Lifetime
- 2003-09-25 AT AT03778269T patent/ATE361761T1/de not_active IP Right Cessation
- 2003-09-25 AU AU2003285286A patent/AU2003285286A1/en not_active Abandoned
- 2003-09-26 US US10/529,090 patent/US20060100144A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2004028568A1 (en) | 2004-04-08 |
JP2006503843A (ja) | 2006-02-02 |
JP4237703B2 (ja) | 2009-03-11 |
EP1545623B1 (de) | 2007-05-09 |
ES2285215T3 (es) | 2007-11-16 |
CA2498062A1 (en) | 2004-04-08 |
US20060100144A1 (en) | 2006-05-11 |
ATE361761T1 (de) | 2007-06-15 |
CA2498062C (en) | 2010-05-25 |
DE60313786T2 (de) | 2008-01-24 |
AU2003285286A1 (en) | 2004-04-19 |
EP1545623A1 (de) | 2005-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |