DE60313786D1 - Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 - Google Patents

Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4

Info

Publication number
DE60313786D1
DE60313786D1 DE60313786T DE60313786T DE60313786D1 DE 60313786 D1 DE60313786 D1 DE 60313786D1 DE 60313786 T DE60313786 T DE 60313786T DE 60313786 T DE60313786 T DE 60313786T DE 60313786 D1 DE60313786 D1 DE 60313786D1
Authority
DE
Germany
Prior art keywords
growth factor
binding protein
factor binding
insulinary
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313786T
Other languages
English (en)
Other versions
DE60313786T2 (de
Inventor
Kurt Lang
Andreas Schaubmar
Ralf Schumacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60313786D1 publication Critical patent/DE60313786D1/de
Application granted granted Critical
Publication of DE60313786T2 publication Critical patent/DE60313786T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60313786T 2002-09-27 2003-09-25 Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4 Expired - Lifetime DE60313786T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02021844 2002-09-27
EP02021844 2002-09-27
PCT/EP2003/010658 WO2004028568A1 (en) 2002-09-27 2003-09-25 Conjugates of insulin-like growth factor binding protein-4 and poly (ethylene glycol)

Publications (2)

Publication Number Publication Date
DE60313786D1 true DE60313786D1 (de) 2007-06-21
DE60313786T2 DE60313786T2 (de) 2008-01-24

Family

ID=32039114

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60313786T Expired - Lifetime DE60313786T2 (de) 2002-09-27 2003-09-25 Poly(ethylen glykol)-konjugate von insulinähnlichem wachstumfaktor bindenden protein-4

Country Status (9)

Country Link
US (1) US20060100144A1 (de)
EP (1) EP1545623B1 (de)
JP (1) JP4237703B2 (de)
AT (1) ATE361761T1 (de)
AU (1) AU2003285286A1 (de)
CA (1) CA2498062C (de)
DE (1) DE60313786T2 (de)
ES (1) ES2285215T3 (de)
WO (1) WO2004028568A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006034832A2 (en) * 2004-09-27 2006-04-06 Univ Muenchen L Maximilians Use of igfbp-2 in senescence diseases and for the maintenance of organ functions
WO2006094530A1 (en) * 2005-03-11 2006-09-14 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
US8034792B2 (en) * 2007-09-11 2011-10-11 University Of Massachusetts Insulin-like growth factor binding protein 7 for treatment of cancer
JP5758888B2 (ja) 2009-07-06 2015-08-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重特異性ジゴキシゲニン結合抗体
WO2011056799A1 (en) * 2009-11-05 2011-05-12 Sangart, Inc. Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material
RU2013135175A (ru) 2011-01-03 2015-02-10 Ф. Хоффманн-Ля Рош Аг Фармацевтическая композиция комплекса антитела против дигоксигенина и дигоксигенина, конъюгированного с пептидом
WO2013040504A2 (en) 2011-09-14 2013-03-21 University Of Massachusetts Srpx for treatment of cancer
MX2017002140A (es) * 2014-08-19 2017-08-21 Biogen Ma Inc Metodo de pegilacion.
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
CN107708679A (zh) 2015-06-04 2018-02-16 安特里阿比奥有限公司 用于制备位点特异性蛋白质偶联物的胺聚乙二醇化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004775A (en) * 1990-08-03 1999-12-21 The Salk Institute For Biological Studies DNA encoding IGFBP-4
US5212074A (en) * 1990-08-28 1993-05-18 Chiron Corporation Genetic material encoding new insulin-like growth factor binding protein igfbp-6
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US6207640B1 (en) * 1994-04-07 2001-03-27 Genentech, Inc. Treatment of partial growth hormone insensitivity syndrome
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6841386B2 (en) * 2001-04-10 2005-01-11 Viacell, Inc. Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein
JP2005508295A (ja) * 2001-06-07 2005-03-31 エフ．ホフマン−ラ　ロシュ　アーゲー Ｉｇｆ結合タンパク質の変異体、およびそれらのアゴニストの作製法

Also Published As

Publication number Publication date
WO2004028568A1 (en) 2004-04-08
JP2006503843A (ja) 2006-02-02
JP4237703B2 (ja) 2009-03-11
EP1545623B1 (de) 2007-05-09
ES2285215T3 (es) 2007-11-16
CA2498062A1 (en) 2004-04-08
US20060100144A1 (en) 2006-05-11
ATE361761T1 (de) 2007-06-15
CA2498062C (en) 2010-05-25
DE60313786T2 (de) 2008-01-24
AU2003285286A1 (en) 2004-04-19
EP1545623A1 (de) 2005-06-29

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