DE60238497D1 - Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung - Google Patents

Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung

Info

Publication number
DE60238497D1
DE60238497D1 DE60238497T DE60238497T DE60238497D1 DE 60238497 D1 DE60238497 D1 DE 60238497D1 DE 60238497 T DE60238497 T DE 60238497T DE 60238497 T DE60238497 T DE 60238497T DE 60238497 D1 DE60238497 D1 DE 60238497D1
Authority
DE
Germany
Prior art keywords
immunoglobulin
production
particular frame
frame scaffold
scaffold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238497T
Other languages
English (en)
Inventor
Mei Yun Zhang
Stefan Schillberg
Sabine Zimmermann
Fiore Stefano Di
Neil Emans
Rainer Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Application granted granted Critical
Publication of DE60238497D1 publication Critical patent/DE60238497D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
DE60238497T 2001-09-14 2002-09-13 Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung Expired - Lifetime DE60238497D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31890401P 2001-09-14 2001-09-14
PCT/US2002/029003 WO2003025124A2 (en) 2001-09-14 2002-09-13 Immunoglobulin having particular framework scaffold and methods of making and using

Publications (1)

Publication Number Publication Date
DE60238497D1 true DE60238497D1 (de) 2011-01-13

Family

ID=23240056

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60238497T Expired - Lifetime DE60238497D1 (de) 2001-09-14 2002-09-13 Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung

Country Status (5)

Country Link
US (1) US20050037420A1 (de)
EP (1) EP1434800B1 (de)
AU (1) AU2002324973A1 (de)
DE (1) DE60238497D1 (de)
WO (1) WO2003025124A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002359913A1 (en) * 2001-12-20 2003-07-09 Agricultural Research Council Semi-synthetic antibody fragment combinatorial library based on avian immunoglobulin genes
KR20060069825A (ko) * 2003-08-01 2006-06-22 제넨테크, 인크. 제한된 다양성을 갖는 항체 ｃｄｒ 폴리펩티드 서열
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US20090028854A1 (en) * 2005-06-10 2009-01-29 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 SITE-DIRECTED MUTANT
WO2007056441A2 (en) 2005-11-07 2007-05-18 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
WO2007064919A2 (en) * 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
AU2007249408A1 (en) * 2006-05-09 2007-11-22 Genentech, Inc. Binding polypeptides with optimized scaffolds
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
PT3354657T (pt) 2009-09-22 2022-05-06 Medicago Inc Método de preparação de proteínas derivadas de plantas
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
WO2014016737A1 (en) * 2012-07-24 2014-01-30 Pfizer Inc. Novel chicken monoclonal antibodies against human phosphorylated tau and uses thereof
KR20160023725A (ko) * 2013-07-03 2016-03-03 서울대학교산학협력단 시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합
AU2021232512A1 (en) * 2020-03-02 2022-09-29 The Regents Of The University Of California Chimeric antigen receptors and related methods and compositions for the treatment of cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
AU717611B2 (en) * 1994-10-28 2000-03-30 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Tumor-specific antibody fragments, fusion proteins, and uses thereof
CN1354671A (zh) * 1998-11-02 2002-06-19 加利福尼亚大学董事会 抑制受磷蛋白活性以治疗心脏病和心力衰竭的方法
EP1479694B1 (de) * 1999-12-28 2016-10-26 ESBATech, an Alcon Biomedical Research Unit LLC ScFv Intrakörper mit definierter Struktur ("Framework"), der in einer reduzierenden Umgebung stabil ist
IT1307309B1 (it) * 1999-12-30 2001-10-30 Enea Ente Nuove Tec Peptidi stabilizzanti, polipeptidi ed anticorpi che li comprendono.
WO2003089475A2 (en) * 2002-04-22 2003-10-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi

Also Published As

Publication number Publication date
WO2003025124A2 (en) 2003-03-27
EP1434800B1 (de) 2010-12-01
US20050037420A1 (en) 2005-02-17
EP1434800A2 (de) 2004-07-07
WO2003025124A3 (en) 2003-09-18
AU2002324973A1 (en) 2003-04-01
EP1434800A4 (de) 2006-05-10

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DE60238497D1 (de) Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung
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