DE60238059D1 - Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid - Google Patents

Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid

Info

Publication number: DE60238059D1
Authority: DE; Germany
Prior art keywords: pravastatin; compound; composition containing; ppar alpha; polyglycolised glyceride
Prior art date: 2001-08-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60238059T

Other languages

English (en)

Inventor

Francis Vanderbist

Arthur Deboeck

Philippe Baudier

Antonio Sereno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Galephar MF

Original Assignee

Galephar MF

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-08-07

Publication date

2010-12-02

2002-08-07 Application filed by Galephar MF filed Critical Galephar MF

2002-08-07 Priority claimed from PCT/BE2002/000135 external-priority patent/WO2003013608A1/en

2010-12-02 Application granted granted Critical

2010-12-02 Publication of DE60238059D1 publication Critical patent/DE60238059D1/de

2022-08-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title abstract 2
229960002965 pravastatin Drugs 0.000 title abstract 2
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
238000013270 controlled release Methods 0.000 abstract 1
229960000701 fenofibric acid Drugs 0.000 abstract 1
MQOBSOSZFYZQOK-UHFFFAOYSA-N fenofibric acid Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 MQOBSOSZFYZQOK-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940074796 pravastatin and fenofibrate Drugs 0.000 abstract 1
TUZYXOIXSAXUGO-PZAWKZKUSA-M pravastatin(1-) Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-M 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60238059T 2001-08-07 2002-08-07 Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid Expired - Lifetime DE60238059D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
BE0100133		2001-08-07
PCT/BE2001/000147 WO2003013607A1 (en)	2001-08-07	2001-09-07	ORAL PHARMACEUTICAL COMPOSITION CONTAINING A COMBINATION OF FENOFIBRATE AND A HMG-CoA REDUCTASE INHIBITOR
PCT/BE2002/000135 WO2003013608A1 (en)	2001-08-07	2002-08-07	ORAL PHARMACEUTICAL COMPOSITION CONTAINING A COMBINAITION OF PPARα AND A HMG-COA REDUCTASE INHIBITOR

Publications (1)

Publication Number	Publication Date
DE60238059D1 true DE60238059D1 (de)	2010-12-02

Family

ID=3862570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60238059T Expired - Lifetime DE60238059D1 (de)	2001-08-07	2002-08-07	Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid

Country Status (7)

Country	Link
US (2)	US20070092567A1 (de)
AT (2)	ATE322896T1 (de)
DE (1)	DE60238059D1 (de)
DK (1)	DK1414496T3 (de)
ES (1)	ES2352189T3 (de)
PT (1)	PT1414496E (de)
WO (2)	WO2003013607A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005011642A1 (en) *	2003-08-05	2005-02-10	Galephar M/F	Single unit pharmaceutical composition comprising a mixture of a fibrate and an homocysteine reducing agent
EP1651194B1 (de) *	2003-08-06	2010-03-31	Galephar M/F	Stabile pharmazeutische zubereitungen zur kontrollierten freisetzung von fenofibrat and pravastatin
CN103040798A (zh) *	2011-11-08	2013-04-17	深圳信立泰药业股份有限公司	一种苯扎贝特缓释药物组合物
US9849184B2 (en)	2011-12-14	2017-12-26	Lts Lohmann Therapie-Systeme Ag	Wafer and capsule formulations with enhanced dissolution rates for fenofibrate
KR102501636B1 (ko) *	2021-12-07	2023-02-21	에이스바이오팜 주식회사	페노피브린산을 포함하는 경구용 정제 및 이의 제조방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2039763A1 (en) *	1990-04-30	1991-10-31	Henry Y. Pan	Combination of pravastatin and a fibric acid derivative, and method for treating dyslipidemia using such combination
CA2048395A1 (en) *	1990-08-23	1992-02-24	Henry Y. Pan	Method for preventing onset of or treating type iii hyperlipoproteinemia employing pravastatin
BE1011363A3 (fr) *	1997-09-11	1999-08-03	Smb Technology	Capsules semi-solides autoemulsionnables matricielles a action prolongee.
DE19858789A1 (de) *	1998-12-18	2000-06-21	Bayer Ag	Kombination von Cerivastatin und Fibraten
US6383471B1 (en) *	1999-04-06	2002-05-07	Lipocine, Inc.	Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6368620B2 (en) *	1999-06-11	2002-04-09	Abbott Laboratories	Formulations comprising lipid-regulating agents
US6372251B2 (en) *	1999-06-11	2002-04-16	Abbott Laboratories	Formulations comprising lipid-regulating agents
KR100801588B1 (ko) *	1999-09-21	2008-02-05	스키에파마 캐나다 인코포레이티드	생물학적 유효 물질의 표면 변형된 미립자 조성물
SI1292293T1 (en) *	2000-06-09	2004-06-30	LEK farmacevtska dru�ba d.d.	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
ATE357216T1 (de) *	2001-02-22	2007-04-15	Jagotec Ag	Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen
US6576256B2 (en) *	2001-08-28	2003-06-10	The Brigham And Women's Hospital, Inc.	Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin

2001
- 2001-09-07 WO PCT/BE2001/000147 patent/WO2003013607A1/en unknown
2002
- 2002-04-05 WO PCT/BE2002/000051 patent/WO2003013501A1/en not_active Application Discontinuation
- 2002-07-17 AT AT02748487T patent/ATE322896T1/de not_active IP Right Cessation
- 2002-08-07 PT PT02766983T patent/PT1414496E/pt unknown
- 2002-08-07 DE DE60238059T patent/DE60238059D1/de not_active Expired - Lifetime
- 2002-08-07 DK DK02766983.7T patent/DK1414496T3/da active
- 2002-08-07 ES ES02766983T patent/ES2352189T3/es not_active Expired - Lifetime
- 2002-08-07 AT AT02766983T patent/ATE485058T1/de active
2006
- 2006-02-06 US US11/347,822 patent/US20070092567A1/en not_active Abandoned
2010
- 2010-07-07 US US12/805,021 patent/US20150037414A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20070092567A1 (en)	2007-04-26
US20150037414A1 (en)	2015-02-05
ES2352189T3 (es)	2011-02-16
DK1414496T3 (da)	2011-01-24
WO2003013501A1 (en)	2003-02-20
PT1414496E (pt)	2012-04-20
ATE485058T1 (de)	2010-11-15
ATE322896T1 (de)	2006-04-15
WO2003013607A1 (en)	2003-02-20

Publication	Publication Date	Title
DE60127457D1 (de)	2007-05-03	Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen
ID30205A (id)	2001-11-15	Asam-asam lemak esensial dalam pencegahan kejadian-kejadian kardiovaskular
ATE236627T1 (de)	2003-04-15	Pharmazeutische zubereitung enhaltend eicosapentaensäure und/oder stearidonsäure
IT8423086A1 (it)	1986-04-10	Composizione farmaceutica o dietetica ad elevata attivita' antitrombotica e antiarteriosclerotica
BR0309740A (pt)	2005-02-22	Uso de ácido eicosapentaenóico (epa), ácido docosaexaenóico (dha) ou de uma mistura de epa e dha ou de um sal ou derivado farmaceuticamente aceitáveis dos mesmos
HUP0202342A2 (hu)	2002-11-28	Esszenciális zsírsavakat és homociszteinszint csökkentő hatóanyagokat tartalmazó gyógyászati és élelmiszer-készítmények
JPS57145803A (en)	1982-09-09	External decoloring agent for skin
ATE129894T1 (de)	1995-11-15	Kurzbettige, einfach ungesättigte fettsäuren enthaltende nahrungsmittel und pharmazeutische zusammensetzungen sowie deren anwendungen.
NZ217703A (en)	1989-01-06	2-(2-fluoro-4-biphenylyl) propionic acid compositions
ATE317280T1 (de)	2006-02-15	Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung
DE69922496D1 (de)	2005-01-13	Nahrungsmittel enthaltend eine mesomorphe phase aus monoglyceriden
EP0341707A3 (en)	1990-03-14	Phenylethanol ester of ortho-cinnamic acid, its preparation and use as fragrance compound
NZ218734A (en)	1990-03-27	Tablets containing coated microspheres which contain ibuprofen (2-(4-isobutyl phenyl)propanoic acid)
SI1651194T1 (sl)	2010-08-31	Stabilni farmacevtski sestavki za nadzorovano sproĹˇÄŤanje, ki vsebujejo fenofibrat in pravastatin
DE60238059D1 (de)	2010-12-02	Zusammensetzung enthaltend eine kombination aus einem ppar-alpha, pravastatin und polyglykolisiertem glyzerid
JP2002536304A5 (de)	2007-03-29
NO932843L (no)	1994-02-14	Farmasoeytiske preparater
KR960700701A (ko)	1996-02-24	파라세타몰 및 l-시스테인 또는 이것의 전구물질을 함유하는 약제조성물(pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof)
DE60008392D1 (de)	2004-03-25	Nicht-hygroskopische salze aktiver inhaltsstoffe, die therapeutische und/oder ernährungsphysiologische eigenschaften haben und oral verabreichbare zusammensetzungen, die diese enthalten
CA2427289A1 (en)	2002-05-23	Fat composition and hexacosanoic acid depressant for oral or enteral administration
AU586881B2 (en)	1989-07-27	New esters of cyclopropane carboxylic acid and of 2,3-dihydro-4-phenyl-1h-inden-2-ol, their preparation, their use in the fight against parasites and the compositions containing them
JPS57194755A (en)	1982-11-30	Composition for pisciculture
DE69423623T2 (de)	2000-08-31	Aminosäureergänzung
JPS52130926A (en)	1977-11-02	Medicinal composition comprising pentazocine and salicylamide
AR036186A1 (es)	2004-08-18	Composicion oral de telitromicina con sabor enmascarado