DE60224805D1 - 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazine un - Google Patents
1-glycinyl-4-(1-methylpiperidin-4-yl)piperazine unInfo
- Publication number
- DE60224805D1 DE60224805D1 DE60224805T DE60224805T DE60224805D1 DE 60224805 D1 DE60224805 D1 DE 60224805D1 DE 60224805 T DE60224805 T DE 60224805T DE 60224805 T DE60224805 T DE 60224805T DE 60224805 D1 DE60224805 D1 DE 60224805D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- glycinyl
- methylpiperidin
- piperazine
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30763401P | 2001-07-26 | 2001-07-26 | |
| US307634P | 2001-07-26 | ||
| US31146201P | 2001-08-13 | 2001-08-13 | |
| US311462P | 2001-08-13 | ||
| US33931701P | 2001-12-12 | 2001-12-12 | |
| US339317P | 2001-12-12 | ||
| PCT/US2002/021292 WO2003010160A2 (en) | 2001-07-26 | 2002-07-24 | 1-glycinyl-4 (methylpiperidin-4-yl) piperazines and -piperridines as factor xa antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60224805D1 true DE60224805D1 (de) | 2008-03-13 |
| DE60224805T2 DE60224805T2 (de) | 2009-01-22 |
Family
ID=27405265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60224805T Expired - Fee Related DE60224805T2 (de) | 2001-07-26 | 2002-07-24 | 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazine und -piperidine als faktor-xa-antagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7265121B2 (de) |
| EP (1) | EP1409479B1 (de) |
| AT (1) | ATE384713T1 (de) |
| AU (1) | AU2002322396A1 (de) |
| DE (1) | DE60224805T2 (de) |
| ES (1) | ES2298386T3 (de) |
| WO (1) | WO2003010160A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE298236T1 (de) * | 2001-12-12 | 2005-07-15 | Lilly Co Eli | Bestimmte glycin-derivate als faktor xa inhibitoren zur verwendung in der behandlung von thrombose |
| EA007300B1 (ru) * | 2002-04-01 | 2006-08-25 | Эли Лилли Энд Компани | Некоторые производные 1-(d-циклопропилглицинил)-4-(пиперидин-4-ил) пиперазина в качестве ингибиторов серинпротеазы фактора ха |
| WO2005058823A1 (ja) | 2003-12-17 | 2005-06-30 | Takeda Pharmaceutical Company Limited | ウレア誘導体、その製造法及び用途 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| CN107089928A (zh) * | 2017-05-07 | 2017-08-25 | 济南同路医药科技发展有限公司 | N‑Boc‑L‑炔丙基甘氨酸的合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995034311A1 (en) * | 1994-06-13 | 1995-12-21 | Merck & Co., Inc. | Piperazine compounds promote release of growth hormone |
| US6566373B2 (en) * | 1997-05-06 | 2003-05-20 | Smithkline Beecham Corporation | Protease inhibitors |
| WO1999011658A1 (en) | 1997-08-29 | 1999-03-11 | Proteus Molecular Design Ltd. | Meta-benzamidine derivatives as serin protease inhibitors |
| ES2248084T3 (es) * | 1999-06-14 | 2006-03-16 | Eli Lilly And Company | Inhibidores de serinproteasa. |
| WO2000076970A2 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Serine protease inhibitors |
| DE10041402A1 (de) | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| TWI257389B (en) * | 2001-06-12 | 2006-07-01 | Lilly Co Eli | Pharmaceutical compound |
-
2002
- 2002-07-24 WO PCT/US2002/021292 patent/WO2003010160A2/en active IP Right Grant
- 2002-07-24 EP EP02756385A patent/EP1409479B1/de not_active Expired - Lifetime
- 2002-07-24 DE DE60224805T patent/DE60224805T2/de not_active Expired - Fee Related
- 2002-07-24 AT AT02756385T patent/ATE384713T1/de not_active IP Right Cessation
- 2002-07-24 US US10/483,264 patent/US7265121B2/en not_active Expired - Fee Related
- 2002-07-24 ES ES02756385T patent/ES2298386T3/es not_active Expired - Lifetime
- 2002-07-24 AU AU2002322396A patent/AU2002322396A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE384713T1 (de) | 2008-02-15 |
| DE60224805T2 (de) | 2009-01-22 |
| ES2298386T3 (es) | 2008-05-16 |
| AU2002322396A1 (en) | 2003-02-17 |
| US7265121B2 (en) | 2007-09-04 |
| WO2003010160A3 (en) | 2003-10-02 |
| US20050026928A1 (en) | 2005-02-03 |
| EP1409479B1 (de) | 2008-01-23 |
| EP1409479A2 (de) | 2004-04-21 |
| WO2003010160A2 (en) | 2003-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8339 | Ceased/non-payment of the annual fee |