DE60222378D1 - Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben - Google Patents

Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben

Info

Publication number
DE60222378D1
DE60222378D1 DE60222378T DE60222378T DE60222378D1 DE 60222378 D1 DE60222378 D1 DE 60222378D1 DE 60222378 T DE60222378 T DE 60222378T DE 60222378 T DE60222378 T DE 60222378T DE 60222378 D1 DE60222378 D1 DE 60222378D1
Authority
DE
Germany
Prior art keywords
fluorescence
metallic
nanoloch
production
fluorescence analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222378T
Other languages
English (en)
Other versions
DE60222378T2 (de
Inventor
Akito Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp
Publication of DE60222378D1 publication Critical patent/DE60222378D1/de
Application granted granted Critical
Publication of DE60222378T2 publication Critical patent/DE60222378T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE60222378T 2001-01-12 2002-01-09 Fluoreszenzanalseelement mit der Verwendung einer metallischen Nanovertiefung und Verfahren zur Herstellung desselben Expired - Lifetime DE60222378T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001005041 2001-01-12
JP2001005041A JP3525142B2 (ja) 2001-01-12 2001-01-12 金属ナノウェルを用いた蛍光分析用素子及びその製造方法
PCT/JP2002/000026 WO2002056012A1 (fr) 2001-01-12 2002-01-09 Element d'analyse par fluorescence au moyen d'un nanopuits metallique et procede de production de cet element

Publications (2)

Publication Number Publication Date
DE60222378D1 true DE60222378D1 (de) 2007-10-25
DE60222378T2 DE60222378T2 (de) 2008-06-12

Family

ID=18873135

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60222378T Expired - Lifetime DE60222378T2 (de) 2001-01-12 2002-01-09 Fluoreszenzanalseelement mit der Verwendung einer metallischen Nanovertiefung und Verfahren zur Herstellung desselben

Country Status (6)

Country Link
US (1) US20040029152A1 (de)
EP (1) EP1353179B1 (de)
JP (1) JP3525142B2 (de)
AT (1) ATE373235T1 (de)
DE (1) DE60222378T2 (de)
WO (1) WO2002056012A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1027031C2 (nl) * 2004-09-13 2006-03-14 Univ Delft Tech Titerplaat.
WO2007094817A2 (en) * 2005-08-02 2007-08-23 University Of Utah Research Foundation Biosensors including metallic nanocavities
US8535616B2 (en) * 2005-08-02 2013-09-17 Moxtek, Inc. Sub-wavelength metallic apertures as light enhancement devices
US20070148677A1 (en) * 2005-12-02 2007-06-28 Chagovetz Alexander M Methods and systems for acquiring real-time quantitative melt data
US7595150B2 (en) * 2006-06-30 2009-09-29 Searete Llc Method of applying an elongated molecule to a surface
US7851028B2 (en) 2006-06-30 2010-12-14 The Invention Science Fund I, Llc Method of combing an elongated molecule
US7618771B2 (en) 2006-06-30 2009-11-17 Searete Llc Method of combing a nucleic acid
JP2008051512A (ja) * 2006-08-22 2008-03-06 Fujifilm Corp 近接場光を用いたセンサおよびその作製方法
CA2677833C (en) * 2007-01-22 2016-05-03 Wafergen, Inc. Apparatus for high throughput chemical reactions
JP5222599B2 (ja) * 2007-07-20 2013-06-26 株式会社日立ハイテクノロジーズ 核酸分析デバイス及びそれを用いた核酸分析装置
CL2009000560A1 (es) 2008-03-11 2010-02-19 Univ Duke Un metodo para endurecer un medio endurecible por radiacion que comprende colocar una composicion dentro de un objeto para ser endurecido, la aplicacion de al menos uno elegido entre rayos x, rayos gama o haz de electrones a traves del objeto y dentro de la composicion.
DE602008002705D1 (de) 2008-03-13 2010-11-04 Icrea Verfahren zur Herstellung von molekular plasmonischen Nanostrukturen
WO2009134612A2 (en) 2008-04-11 2009-11-05 University Of Utah Research Foundation Methods and compositions related to quantitative array based methylation analysis
JP4997181B2 (ja) * 2008-06-13 2012-08-08 株式会社日立ハイテクノロジーズ 核酸分析デバイス及び核酸分析装置
JP5066110B2 (ja) 2009-01-30 2012-11-07 株式会社日立ハイテクノロジーズ 蛍光分析装置、及び蛍光分析方法
JP5707030B2 (ja) * 2009-04-02 2015-04-22 株式会社日立ハイテクノロジーズ 核酸分析デバイス、及び核酸分析装置
FR2951271B1 (fr) * 2009-10-13 2012-11-16 Univ Troyes Technologie Support d'echantillon, procede et systeme d'imagerie par fonctionnalisation du substrat
EP2513630B1 (de) * 2009-12-17 2016-05-25 Chris Geddes Detektionssystem umfassend mischmetallsubstrate zur metallverstärkten fluoreszenz
KR20120010513A (ko) 2010-07-26 2012-02-03 삼성전자주식회사 바이오 물질 수용소자와 그 제조 및 동작방법
KR101663183B1 (ko) 2010-08-26 2016-10-06 삼성전자주식회사 열전재료, 이를 포함하는 열전모듈과 열전장치
JP5372876B2 (ja) * 2010-09-10 2013-12-18 株式会社日立ハイテクノロジーズ 核酸分析デバイス，核酸分析装置、及び核酸分析方法
CN102604140B (zh) * 2012-03-21 2013-12-11 陕西师范大学 含胆固醇的聚合物荧光传感薄膜的制备方法
CN103980884B (zh) * 2014-05-21 2016-09-21 南京理工大学 Al3+荧光传感器、合成方法及应用
JP2016012114A (ja) * 2014-06-02 2016-01-21 オリンパス株式会社 照明装置、これを有する顕微鏡装置及び顕微鏡観察方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
CA2076709A1 (en) * 1992-08-24 1994-02-25 Ulrich J. Krull Amplified fluorescence emission for chemical transduction
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5776785A (en) * 1996-12-30 1998-07-07 Diagnostic Products Corporation Method and apparatus for immunoassay using fluorescent induced surface plasma emission
DE19715483A1 (de) * 1997-04-14 1998-10-15 Boehringer Mannheim Gmbh Methode zur gleichzeitigen Bestimmung von biomolekularen Wechselwirkungen mittels Plasmonenresonanz undFluoreszenzdetektion
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP3647267B2 (ja) * 1998-05-29 2005-05-11 キヤノン株式会社 面発光レーザーを用いた表面プラズモン共鳴センサ装置
US6262216B1 (en) * 1998-10-13 2001-07-17 Affymetrix, Inc. Functionalized silicon compounds and methods for their synthesis and use
US6236033B1 (en) * 1998-12-09 2001-05-22 Nec Research Institute, Inc. Enhanced optical transmission apparatus utilizing metal films having apertures and periodic surface topography
US6429027B1 (en) * 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
JP3872227B2 (ja) * 1999-02-26 2007-01-24 北斗科学産業株式会社 新規の生物学的チップ及び分析方法
US6489102B2 (en) * 1999-08-05 2002-12-03 Wisconsin Alumni Research Foundation Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
JP3249954B2 (ja) * 1999-07-07 2002-01-28 科学技術振興事業団 蛍光免疫分析方法及び装置
WO2001009388A1 (en) * 1999-07-30 2001-02-08 The Penn State Research Foundation Instruments, methods and reagents for surface plasmon resonance
US6395483B1 (en) * 1999-09-02 2002-05-28 3M Innovative Properties Company Arrays with mask layers
EP1305659B1 (de) * 2000-07-21 2004-12-08 Micro Managed Photons A/S Bandlücken strukturen für oberflächenplasmonenpolariton
CA2314398A1 (en) * 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays

Also Published As

Publication number Publication date
JP2002214142A (ja) 2002-07-31
US20040029152A1 (en) 2004-02-12
ATE373235T1 (de) 2007-09-15
EP1353179B1 (de) 2007-09-12
EP1353179A1 (de) 2003-10-15
JP3525142B2 (ja) 2004-05-10
EP1353179A4 (de) 2004-05-19
DE60222378T2 (de) 2008-06-12
WO2002056012A1 (fr) 2002-07-18

Similar Documents

Publication Publication Date Title
DE60222378D1 (de) Fluoreszensanalyseelement mit der anwendung eines metallischen nanolochs und verfahren zur herstellung desselben
CN106691462B (zh) 检测装置和相关使用方法
DE60042738D1 (de) Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
WO2014144133A1 (en) Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
EP1256795A3 (de) Biochipleser
DE60026337D1 (de) Verfahren zur diagnose von leberkrankheit unter verwendung von biochemischen merkmalen
DE60045739D1 (de) Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
EE200300132A (et) Klaasmahuti ning protsess pinnakattega ja/või etiketitud klaasmahuti saamiseks
DE69522176D1 (de) Verfahren zur Dämpfung der Fluoreszenz von Fluoreszenzmarkierten Oligonukleotiden in Lösung
CN101346626A (zh) 用于测定具有生物来源和复杂组成的样品中一种或多种分析物的方法及其用途
DE60016178D1 (de) Verfahren zur diagnose und zur charakterisierung von schlaganfall
ATE525462T1 (de) Proteomanalyseverfahren für phosphoryliertes protein
ATE496298T1 (de) Methode um die sensitivität einer luminesenz assay zu erhöhen
US9050615B2 (en) Apparatus and method for coating substrates for analyte detection by means of an affinity assay method
ATE390633T1 (de) Reagens zum nachweis eines morbus-alzheimer- risikofaktors, nachweiskit dafür und verfahren zum nachweis eines morbus-alzheimer-risikofaktors unter verwendung davon
WO2004102194A9 (ja) 選択結合性物質固定化担体
DE60209537D1 (de) Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander
ATE422671T1 (de) Verfahren zur diagnose von morbus alzheimer
DE60207490D1 (de) Verfahren zur Herstellung von (Meth)Acrylsäureanhydrid
DE602004026500D1 (de) Verfahren zur Markierung phosphorylierten Peptiden, Komplexverbindunger, Verfahren zu deren Herstellung und Zwischenprodukte
EP1881471A3 (de) Etikettband mit Identifizierungscode
DE60334315D1 (de) Verfahren, biosensoren und kits zum nachweis und zur identifizierung von pilzen
EP1010764A3 (de) Hybridisierungsnachweisverfahren unter Verwendung von Biochips
DE60109739D1 (de) Verfahren zur herstellung und immobilisierung von nukleinsäure auf einem silan-modifizierten festträger
DE602004011730D1 (de) Verfahren zur Herstellung von Valsartan

Legal Events

Date Code Title Description
8364 No opposition during term of opposition