DE60218048D1 - THIOPHEN COMPOUNDS AS A MEDICAMENT - Google Patents

THIOPHEN COMPOUNDS AS A MEDICAMENT

Info

Publication number
DE60218048D1
DE60218048D1 DE60218048T DE60218048T DE60218048D1 DE 60218048 D1 DE60218048 D1 DE 60218048D1 DE 60218048 T DE60218048 T DE 60218048T DE 60218048 T DE60218048 T DE 60218048T DE 60218048 D1 DE60218048 D1 DE 60218048D1
Authority
DE
Germany
Prior art keywords
sub
medicament
thiophen
compounds
thiophen compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218048T
Other languages
German (de)
Other versions
DE60218048T2 (en
Inventor
David Griffiths
Craig Johnstone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60218048D1 publication Critical patent/DE60218048D1/en
Application granted granted Critical
Publication of DE60218048T2 publication Critical patent/DE60218048T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to thiophene carboxamides of formula (I), wherein R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB>, A, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
DE60218048T 2001-07-25 2002-07-19 THIOPHEN COMPOUNDS AS A MEDICAMENT Expired - Lifetime DE60218048T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102617A SE0102617D0 (en) 2001-07-25 2001-07-25 Novel compounds
SE0102617 2001-07-25
PCT/SE2002/001402 WO2003010163A1 (en) 2001-07-25 2002-07-19 Novel compounds

Publications (2)

Publication Number Publication Date
DE60218048D1 true DE60218048D1 (en) 2007-03-22
DE60218048T2 DE60218048T2 (en) 2007-08-09

Family

ID=20284945

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218048T Expired - Lifetime DE60218048T2 (en) 2001-07-25 2002-07-19 THIOPHEN COMPOUNDS AS A MEDICAMENT

Country Status (17)

Country Link
US (1) US7098240B2 (en)
EP (1) EP1421079B1 (en)
JP (2) JP2004536869A (en)
KR (1) KR20040018521A (en)
CN (1) CN1538968A (en)
AT (1) ATE353327T1 (en)
BR (1) BR0211472A (en)
CA (1) CA2454702A1 (en)
DE (1) DE60218048T2 (en)
ES (1) ES2280559T3 (en)
IL (1) IL160023A0 (en)
MX (1) MXPA04000755A (en)
NO (1) NO20040314L (en)
NZ (1) NZ530751A (en)
SE (1) SE0102617D0 (en)
WO (1) WO2003010163A1 (en)
ZA (1) ZA200400494B (en)

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GB0003154D0 (en) * 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
SK288015B6 (en) * 2001-06-11 2012-11-05 Virochem Pharma Inc. Thiophene derivatives as antiviral agents for flavivirus infection
SE0102616D0 (en) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
US7166639B2 (en) * 2001-10-04 2007-01-23 Smithkline Beecham Corporation NF-κB inhibitors
US7375131B2 (en) * 2002-06-06 2008-05-20 Smithklinebeecham Corp. NF-κB inhibitors
CN100413861C (en) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 Compounds and methods for the treatment or prevention of flavivirus infections
SE0300092D0 (en) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300091D0 (en) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050113566A1 (en) * 2003-04-25 2005-05-26 Player Mark R. Inhibitors of C-FMS kinase
US7427683B2 (en) * 2003-04-25 2008-09-23 Ortho-Mcneil Pharmaceutical, Inc. c-fms kinase inhibitors
MXPA05011503A (en) * 2003-04-25 2006-05-31 Johnson & Johnson C-fms kinase inhibitors.
US7790724B2 (en) 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
EP1493739A1 (en) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Thiophene derivatives of aminoacids, process for the preparation thereof and compositions containing them
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
EP2305671A1 (en) * 2004-01-05 2011-04-06 AstraZeneca AB Thiophene and thiazole derivatives as CHK1 inhibitors
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
PE20060748A1 (en) 2004-09-21 2006-10-01 Smithkline Beecham Corp INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2
AP2007004245A0 (en) 2005-05-13 2007-12-31 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
WO2007005534A2 (en) 2005-06-30 2007-01-11 Smithkline Beecham Corporation Chemical compounds
NZ576780A (en) 2006-11-15 2011-12-22 Virochem Pharma Inc Thiophene analogues for the treatment or prevention of flavivirus infections
CN101583598B (en) * 2007-01-15 2012-09-12 参天制药株式会社 Novel indole derivative having inhibitory activity on i kappa b kinase
AR065804A1 (en) 2007-03-23 2009-07-01 Smithkline Beecham Corp COMPOSITE OF INDOL CARBOXAMIDE, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT AND USE OF THIS COMPOUND TO PREPARE A MEDICINAL PRODUCT
RU2499592C2 (en) 2008-04-21 2013-11-27 Отономи, Инк. Pharmaceutical composition for treating ear diseases
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
CA2730281A1 (en) * 2008-07-14 2010-01-21 Santen Pharmaceutical Co., Ltd. Novel indole derivative having, carbamoyl group, ureido group and substituted oxy group
CN102131774A (en) 2008-08-25 2011-07-20 参天制药株式会社 Novel pyrrole derivative having, as substituents, ureide group, aminocarbonyl group and bicyclic group which may have substituent
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
EP2520292A1 (en) 2011-05-06 2012-11-07 Helmholtz-Zentrum für Infektionsforschung GmbH Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated disorders
KR20190024983A (en) 2016-06-29 2019-03-08 오토노미, 인코포레이티드 Triglyceride ear preparations and uses thereof
CN107739370B (en) * 2017-10-26 2021-03-30 中国药科大学 Preparation method and application of pyrrolidone BRD4 protein inhibitor

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Publication number Priority date Publication date Assignee Title
GB1468012A (en) * 1973-08-09 1977-03-23 Beecham Group Ltd 2-amino-3-carboxy-thiophene derivatives
DE3529247A1 (en) 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen USE OF THIENYL UREAS AND ISOHARNS AS AN PERFORMANCE DRIVER IN ANIMALS, NEW THIENYL URINS AND ISOHARNS AND THEIR PRODUCTION
AU3044197A (en) 1996-07-11 1998-02-09 Pfizer Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
PT853083E (en) * 1997-01-06 2001-12-28 Pfizer COMPOSITION OF PYRIDILFURANE AND PYRIDYLTHOPHENE AND ITS PHARMACEUTICAL UTILIZATION
US6809088B2 (en) * 1997-03-24 2004-10-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
US6037340A (en) 1997-05-28 2000-03-14 Cadus Pharmaceutical Corporation Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds
DE19744026A1 (en) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazole derivatives, their preparation and their use in medicinal products
AU2713799A (en) 1998-03-12 1999-09-27 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
HN2000000051A (en) * 1999-05-19 2001-02-02 Pfizer Prod Inc USEFUL HETEROCICLIC DERIVATIVES AS ANTI-TARGET AGENTS
CN100355751C (en) * 2000-03-29 2007-12-19 西克拉塞尔有限公司 2-substd. 4-heteroaryl-pyrimidines and their use in treatment of proliferative disorders
US6414013B1 (en) 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
WO2002030353A2 (en) 2000-10-12 2002-04-18 Smithkline Beecham Corporation NF-λB INHIBITORS

Also Published As

Publication number Publication date
US7098240B2 (en) 2006-08-29
NZ530751A (en) 2005-09-30
CN1538968A (en) 2004-10-20
KR20040018521A (en) 2004-03-03
US20040235821A1 (en) 2004-11-25
ES2280559T3 (en) 2007-09-16
MXPA04000755A (en) 2004-04-20
JP2010111683A (en) 2010-05-20
NO20040314L (en) 2004-03-25
SE0102617D0 (en) 2001-07-25
EP1421079A1 (en) 2004-05-26
IL160023A0 (en) 2004-06-20
DE60218048T2 (en) 2007-08-09
WO2003010163A1 (en) 2003-02-06
ATE353327T1 (en) 2007-02-15
CA2454702A1 (en) 2003-02-06
BR0211472A (en) 2004-11-09
JP2004536869A (en) 2004-12-09
ZA200400494B (en) 2005-04-22
EP1421079B1 (en) 2007-02-07

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