DE60206762D1 - Hexahydroazepino[4,5-g]indole und -indoline als 5-ht-rezeptor-liganden - Google Patents

Hexahydroazepino[4,5-g]indole und -indoline als 5-ht-rezeptor-liganden

Info

Publication number
DE60206762D1
DE60206762D1 DE60206762T DE60206762T DE60206762D1 DE 60206762 D1 DE60206762 D1 DE 60206762D1 DE 60206762 T DE60206762 T DE 60206762T DE 60206762 T DE60206762 T DE 60206762T DE 60206762 D1 DE60206762 D1 DE 60206762D1
Authority
DE
Germany
Prior art keywords
sup
hexahydroazepino
indolines
indole
receptor ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60206762T
Other languages
English (en)
Other versions
DE60206762T2 (de
Inventor
Jian-Min Fu
Kay Morris
Glenn Romero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE60206762D1 publication Critical patent/DE60206762D1/de
Application granted granted Critical
Publication of DE60206762T2 publication Critical patent/DE60206762T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60206762T 2001-07-13 2002-07-10 Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden Expired - Fee Related DE60206762T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30530501P 2001-07-13 2001-07-13
US305305P 2001-07-13
PCT/US2002/019804 WO2003006466A1 (en) 2001-07-13 2002-07-10 Hexahydroazepino (4, 5-g) indoles and indolines as 5-ht receptor ligands

Publications (2)

Publication Number Publication Date
DE60206762D1 true DE60206762D1 (de) 2006-03-02
DE60206762T2 DE60206762T2 (de) 2006-07-13

Family

ID=23180257

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60206762T Expired - Fee Related DE60206762T2 (de) 2001-07-13 2002-07-10 Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden

Country Status (11)

Country Link
US (1) US7022694B2 (de)
EP (1) EP1406902B1 (de)
JP (1) JP2005522408A (de)
AT (1) ATE307133T1 (de)
BR (1) BR0211140A (de)
CA (1) CA2452610A1 (de)
DE (1) DE60206762T2 (de)
DK (1) DK1406902T3 (de)
ES (1) ES2250667T3 (de)
MX (1) MXPA04000358A (de)
WO (1) WO2003006466A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018432A1 (en) * 2002-08-20 2004-03-04 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
CN1688584A (zh) * 2002-08-29 2005-10-26 先灵公司 治疗肥胖和中枢神经***疾病的选择性d1/d5受体拮抗剂
NZ549009A (en) 2004-02-25 2010-08-27 Lilly Co Eli 6-substituted 2,3,4,5-tetrahydro-1H-benzo[D]azepines as 5-HT2C receptor agonists
EP2248524A3 (de) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
CA2619450C (en) 2005-09-01 2013-10-22 Eli Lilly And Company 6-n-linked heterocycle-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028083A2 (en) 2005-09-01 2007-03-08 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
SI1926712T1 (sl) 2005-09-01 2010-01-29 Lilly Co Eli 6-substituirani 2,3.4,5-tetrahidro-1h-benzo(d)azepini kot agonisti 5-ht2c receptorja
DE602006008323D1 (de) 2005-09-01 2009-09-17 Lilly Co Eli 6-substituierte- 2,3,4,5-tetrahydro-1h-benzoädüazepine als 5-ht2c-rezeptoragonisten
JP5528699B2 (ja) 2006-05-16 2014-06-25 武田薬品工業株式会社 縮合複素環化合物およびその用途
EP2789338A3 (de) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Kondensiertes Pyridinderivat und seine Verwendung
EP2510949A4 (de) 2009-12-11 2013-11-13 Astellas Pharma Inc Therapeutikum für fibromyalgie
CN106488702A (zh) 2014-05-05 2017-03-08 曹正兵 抗菌表面涂层
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
EP3753924A1 (de) * 2019-06-18 2020-12-23 AnaMar AB Neue tricyclische 5-ht2-antagonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK26793D0 (da) 1993-03-10 1993-03-10 Novo Nordisk As Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling
US5917053A (en) 1994-09-14 1999-06-29 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
JP2001514631A (ja) 1997-03-07 2001-09-11 ノボ ノルディスク アクティーゼルスカブ ４，５，６，７−テトラヒドロ−チエノ［３，２−ｃ］ピリジン誘導体類、それらの製造方法及び使用
NZ507259A (en) 1998-03-31 2003-07-25 Neurosearch As Indole-2,3-dione-3-oxime derivatives for therapeutic use
GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi

Also Published As

Publication number Publication date
DK1406902T3 (da) 2006-01-30
ATE307133T1 (de) 2005-11-15
EP1406902A1 (de) 2004-04-14
WO2003006466A1 (en) 2003-01-23
CA2452610A1 (en) 2003-01-23
US20030060458A1 (en) 2003-03-27
BR0211140A (pt) 2005-10-25
EP1406902B1 (de) 2005-10-19
US7022694B2 (en) 2006-04-04
MXPA04000358A (es) 2004-05-04
DE60206762T2 (de) 2006-07-13
ES2250667T3 (es) 2006-04-16
JP2005522408A (ja) 2005-07-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee