DE60202203D1 - Neues verfahren zur herstellung von oxabispidinen - Google Patents

Neues verfahren zur herstellung von oxabispidinen

Info

Publication number
DE60202203D1
DE60202203D1 DE2002602203 DE60202203T DE60202203D1 DE 60202203 D1 DE60202203 D1 DE 60202203D1 DE 2002602203 DE2002602203 DE 2002602203 DE 60202203 T DE60202203 T DE 60202203T DE 60202203 D1 DE60202203 D1 DE 60202203D1
Authority
DE
Germany
Prior art keywords
sup
formula
compound
oxabispidines
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2002602203
Other languages
English (en)
Other versions
DE60202203T2 (de
Inventor
Lal Cheema
David Cladingboel
Rhona Sinclair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE60202203D1 publication Critical patent/DE60202203D1/de
Application granted granted Critical
Publication of DE60202203T2 publication Critical patent/DE60202203T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60202203T 2001-04-12 2002-04-12 Neues verfahren zur herstellung von oxabispidinen Expired - Lifetime DE60202203T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0101324A SE0101324D0 (sv) 2001-04-12 2001-04-12 New process
SE0101324 2001-04-12
PCT/SE2002/000727 WO2002083690A1 (en) 2001-04-12 2002-04-12 New process for the preparation of oxabispidines

Publications (2)

Publication Number Publication Date
DE60202203D1 true DE60202203D1 (de) 2005-01-13
DE60202203T2 DE60202203T2 (de) 2005-12-15

Family

ID=20283781

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202203T Expired - Lifetime DE60202203T2 (de) 2001-04-12 2002-04-12 Neues verfahren zur herstellung von oxabispidinen

Country Status (20)

Country Link
US (2) US7169921B2 (de)
EP (1) EP1385850B1 (de)
JP (1) JP4248880B2 (de)
KR (1) KR100848613B1 (de)
CN (1) CN1267435C (de)
AT (1) ATE284405T1 (de)
AU (1) AU2002249748B2 (de)
BR (1) BR0208861A (de)
CA (1) CA2443475A1 (de)
DE (1) DE60202203T2 (de)
ES (1) ES2233809T3 (de)
HK (1) HK1060886A1 (de)
IL (2) IL158249A0 (de)
MX (1) MXPA03009211A (de)
NO (1) NO20034526L (de)
NZ (1) NZ528515A (de)
PT (1) PT1385850E (de)
SE (1) SE0101324D0 (de)
WO (1) WO2002083690A1 (de)
ZA (1) ZA200307676B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
US20040192738A1 (en) * 2003-03-18 2004-09-30 Aventis Pharma Deutschland Gmbh 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxypyridin-3-yl)propyl] benzamide, its use as a medicament, and pharmaceutical preparations comprising it
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
CN101243093A (zh) * 2005-06-13 2008-08-13 阿斯利康(瑞典)有限公司 用于治疗心律不齐的新型氧杂双哌啶化合物
US20090216002A1 (en) * 2005-06-16 2009-08-27 Girindus Ag Synthesis of hydroquinone derivatives
AR057364A1 (es) * 2005-06-20 2007-11-28 Astrazeneca Ab Proceso para el aislamiento de 4-(oxiranilmetoxi) -benzonitrilos
MX2007016498A (es) * 2005-06-20 2008-03-04 Astrazeneca Ab Proceso para la preparacion de 3,7-dihidroxi-1,5-diazaciclooctanos .
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
CA2610205A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the production of (alkoxycarbonylamino)alkyl sulfonates
KR20080028435A (ko) * 2005-06-20 2008-03-31 아스트라제네카 아베 N,n’-이치환된 옥사비스피딘의 제조 방법
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process

Also Published As

Publication number Publication date
US7169921B2 (en) 2007-01-30
CN1267435C (zh) 2006-08-02
EP1385850B1 (de) 2004-12-08
WO2002083690A1 (en) 2002-10-24
EP1385850A1 (de) 2004-02-04
KR20030087065A (ko) 2003-11-12
BR0208861A (pt) 2004-10-19
CA2443475A1 (en) 2002-10-24
NZ528515A (en) 2005-06-24
JP4248880B2 (ja) 2009-04-02
IL158249A0 (en) 2004-05-12
CN1520417A (zh) 2004-08-11
ZA200307676B (en) 2004-07-13
JP2004533432A (ja) 2004-11-04
KR100848613B1 (ko) 2008-07-28
IL158249A (en) 2009-09-01
US20040181060A1 (en) 2004-09-16
ATE284405T1 (de) 2004-12-15
PT1385850E (pt) 2005-03-31
DE60202203T2 (de) 2005-12-15
SE0101324D0 (sv) 2001-04-12
NO20034526D0 (no) 2003-10-09
US20070197519A1 (en) 2007-08-23
HK1060886A1 (en) 2004-08-27
AU2002249748B2 (en) 2008-02-28
MXPA03009211A (es) 2004-01-29
NO20034526L (no) 2003-10-31
ES2233809T3 (es) 2005-06-16

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Legal Events

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