DE602008003221D1 - Prolinamidderivate als nk3-antagonisten - Google Patents

Prolinamidderivate als nk3-antagonisten

Info

Publication number
DE602008003221D1
DE602008003221D1 DE602008003221T DE602008003221T DE602008003221D1 DE 602008003221 D1 DE602008003221 D1 DE 602008003221D1 DE 602008003221 T DE602008003221 T DE 602008003221T DE 602008003221 T DE602008003221 T DE 602008003221T DE 602008003221 D1 DE602008003221 D1 DE 602008003221D1
Authority
DE
Germany
Prior art keywords
antagonists
prolinamide derivatives
prolinamide
derivatives
adhd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008003221T
Other languages
English (en)
Inventor
Bo Han
Henner Knust
Matthias Nettekoven
Hasane Ratni
Xihan Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602008003221D1 publication Critical patent/DE602008003221D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
DE602008003221T 2007-06-07 2008-05-29 Prolinamidderivate als nk3-antagonisten Active DE602008003221D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07109781 2007-06-07
PCT/EP2008/056589 WO2008148689A1 (en) 2007-06-07 2008-05-29 Prolinamide derivatives as nk3 antagonists

Publications (1)

Publication Number Publication Date
DE602008003221D1 true DE602008003221D1 (de) 2010-12-09

Family

ID=39639487

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008003221T Active DE602008003221D1 (de) 2007-06-07 2008-05-29 Prolinamidderivate als nk3-antagonisten

Country Status (14)

Country Link
US (1) US7528136B2 (de)
EP (1) EP2155672B1 (de)
JP (1) JP2010529069A (de)
KR (1) KR101163292B1 (de)
CN (1) CN101679241B (de)
AT (1) ATE486058T1 (de)
AU (1) AU2008258665B2 (de)
BR (1) BRPI0812447A2 (de)
CA (1) CA2689560A1 (de)
DE (1) DE602008003221D1 (de)
ES (1) ES2351378T3 (de)
IL (1) IL202236A0 (de)
MX (1) MX2009013115A (de)
WO (1) WO2008148689A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2433940B9 (de) * 2009-04-28 2015-10-28 Chugai Seiyaku Kabushiki Kaisha Spiroimidazolonderivat
US8314250B2 (en) 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
US8618303B2 (en) * 2011-01-07 2013-12-31 Hoffmann-La Roche Inc. Pyrrolidine derivatives
US9073881B2 (en) 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives
KR20140130449A (ko) 2012-02-24 2014-11-10 에프. 호프만-라 로슈 아게 항바이러스 화합물
NO2930176T3 (de) 2012-12-10 2018-07-07
BR112016003511B8 (pt) 2014-06-09 2023-10-03 Chugai Pharmaceutical Co Ltd Composição farmacêutica que contém derivados de hidantoína e uso dos mesmos
CN105153005A (zh) * 2015-08-05 2015-12-16 上海瑞博化学有限公司 一种4-羰基-脯氨酸衍生物的制备方法
JP7153653B2 (ja) 2017-02-14 2022-10-14 リサーチ トライアングル インスティテュート プロリン系神経ペプチドff受容体モジュレーター
KR102453438B1 (ko) 2020-06-15 2022-10-12 주식회사 한중엔시에스 리저버 일체형 진공 펌프

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1169731A (zh) * 1994-12-13 1998-01-07 诺瓦蒂斯有限公司 速激肽拮抗剂
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
CA2565953A1 (en) * 2004-05-12 2005-11-24 Pfizer Products Inc. Piperidine derivatives as nk1 and nk3 antagonists

Also Published As

Publication number Publication date
KR20100028629A (ko) 2010-03-12
IL202236A0 (en) 2010-06-16
KR101163292B1 (ko) 2012-07-05
EP2155672A1 (de) 2010-02-24
BRPI0812447A2 (pt) 2014-12-02
US7528136B2 (en) 2009-05-05
CN101679241A (zh) 2010-03-24
ES2351378T3 (es) 2011-02-03
AU2008258665A1 (en) 2008-12-11
WO2008148689A1 (en) 2008-12-11
CA2689560A1 (en) 2008-12-11
CN101679241B (zh) 2012-06-27
AU2008258665B2 (en) 2012-07-05
JP2010529069A (ja) 2010-08-26
US20080306086A1 (en) 2008-12-11
ATE486058T1 (de) 2010-11-15
MX2009013115A (es) 2010-01-15
EP2155672B1 (de) 2010-10-27

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