DE602007012589D1 - 4-ä4-Ä(ä3-TERT-BUTYL-1-Ä3-(HYDROXYMETHYL)-PHENYLÜ-1H-PYRAZOL-5-YLü-CARBAMOYL)-AMINOÜ-3-FLUOROPHENOXYü -N-METHYLPYRIDIN-2-CARBOXAMID SOWIE PRODRUGS UND - Google Patents
4-ä4-Ä(ä3-TERT-BUTYL-1-Ä3-(HYDROXYMETHYL)-PHENYLÜ-1H-PYRAZOL-5-YLü-CARBAMOYL)-AMINOÜ-3-FLUOROPHENOXYü -N-METHYLPYRIDIN-2-CARBOXAMID SOWIE PRODRUGS UNDInfo
- Publication number
- DE602007012589D1 DE602007012589D1 DE602007012589T DE602007012589T DE602007012589D1 DE 602007012589 D1 DE602007012589 D1 DE 602007012589D1 DE 602007012589 T DE602007012589 T DE 602007012589T DE 602007012589 T DE602007012589 T DE 602007012589T DE 602007012589 D1 DE602007012589 D1 DE 602007012589D1
- Authority
- DE
- Germany
- Prior art keywords
- methylpyridine
- pyrazol
- prodrugs
- carboxamide
- carbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87583006P | 2006-12-20 | 2006-12-20 | |
US98677307P | 2007-11-09 | 2007-11-09 | |
PCT/US2007/088365 WO2008079968A1 (en) | 2006-12-20 | 2007-12-20 | 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino] -3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007012589D1 true DE602007012589D1 (de) | 2011-03-31 |
Family
ID=39247683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007012589T Active DE602007012589D1 (de) | 2006-12-20 | 2007-12-20 | 4-ä4-Ä(ä3-TERT-BUTYL-1-Ä3-(HYDROXYMETHYL)-PHENYLÜ-1H-PYRAZOL-5-YLü-CARBAMOYL)-AMINOÜ-3-FLUOROPHENOXYü -N-METHYLPYRIDIN-2-CARBOXAMID SOWIE PRODRUGS UND |
Country Status (12)
Country | Link |
---|---|
US (1) | US8101773B2 (de) |
EP (1) | EP2111401B1 (de) |
JP (1) | JP2010514691A (de) |
CN (1) | CN101679362A (de) |
AT (1) | ATE498620T1 (de) |
AU (1) | AU2007336873A1 (de) |
CA (1) | CA2673041A1 (de) |
DE (1) | DE602007012589D1 (de) |
DK (1) | DK2111401T3 (de) |
IL (1) | IL199403A0 (de) |
MX (1) | MX2009006579A (de) |
WO (1) | WO2008079968A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
PT1626714E (pt) | 2003-05-20 | 2007-08-24 | Bayer Pharmaceuticals Corp | Diarilureias para doenças mediadas por pdgfr |
BR122016015715B8 (pt) | 2003-07-23 | 2021-05-25 | Bayer Healthcare Llc | composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico |
CA2581843C (en) * | 2004-09-29 | 2012-05-15 | Bayer Healthcare Ag | Thermodynamically stable form of bay 43-9006 tosylate |
PL1868579T3 (pl) | 2005-03-07 | 2011-03-31 | Bayer Healthcare Llc | Kompozycja farmaceutyczna zawierająca difenylomocznik podstawiony omega-karboksyarylem do leczenia nowotworu |
AR062927A1 (es) * | 2006-10-11 | 2008-12-17 | Bayer Healthcare Ag | 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada |
CN102140093A (zh) * | 2010-02-03 | 2011-08-03 | 上海源力生物技术有限公司 | 吡啶酮酰胺类衍生物、其制备方法及其在医药上的应用 |
AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP2782584B1 (de) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natürliche kombinierte hormonersatzformulierungen und -therapien |
KR20150020683A (ko) * | 2012-06-15 | 2015-02-26 | 바스프 에스이 | 다사티닙 및 선택된 공-결정 형성제를 포함하는 다성분 결정 |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20150210722A1 (en) | 2012-08-29 | 2015-07-30 | Respivert Limited | Kinase inhibitors |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CN105012321A (zh) * | 2015-08-20 | 2015-11-04 | 中国人民解放军第三军医大学第三附属医院 | 替加环素在制备抗胶质瘤药物中的应用 |
WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
CN113662938B (zh) * | 2021-09-26 | 2022-08-16 | 广西科技大学 | 一种胺类衍生物在制备抗肿瘤药物组合物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2295427A1 (de) | 2004-04-30 | 2011-03-16 | Bayer HealthCare, LLC | Substituierte Pyrazolyl-harnstoff-derivate zur Behandlung von Krebs |
DE102005015253A1 (de) | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
JP2009518298A (ja) | 2005-12-01 | 2009-05-07 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | 癌治療に有用な尿素化合物 |
-
2007
- 2007-12-20 DK DK07865924.0T patent/DK2111401T3/da active
- 2007-12-20 US US12/520,609 patent/US8101773B2/en not_active Expired - Fee Related
- 2007-12-20 JP JP2009543220A patent/JP2010514691A/ja active Pending
- 2007-12-20 AT AT07865924T patent/ATE498620T1/de active
- 2007-12-20 MX MX2009006579A patent/MX2009006579A/es not_active Application Discontinuation
- 2007-12-20 AU AU2007336873A patent/AU2007336873A1/en not_active Abandoned
- 2007-12-20 EP EP07865924A patent/EP2111401B1/de not_active Not-in-force
- 2007-12-20 CA CA002673041A patent/CA2673041A1/en not_active Abandoned
- 2007-12-20 DE DE602007012589T patent/DE602007012589D1/de active Active
- 2007-12-20 WO PCT/US2007/088365 patent/WO2008079968A1/en active Application Filing
- 2007-12-20 CN CN200780051553A patent/CN101679362A/zh active Pending
-
2009
- 2009-06-17 IL IL199403A patent/IL199403A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US8101773B2 (en) | 2012-01-24 |
CA2673041A1 (en) | 2008-07-03 |
DK2111401T3 (da) | 2011-05-30 |
JP2010514691A (ja) | 2010-05-06 |
AU2007336873A1 (en) | 2008-07-03 |
EP2111401B1 (de) | 2011-02-16 |
WO2008079968A1 (en) | 2008-07-03 |
CN101679362A (zh) | 2010-03-24 |
IL199403A0 (en) | 2010-03-28 |
EP2111401A1 (de) | 2009-10-28 |
US20100063107A1 (en) | 2010-03-11 |
MX2009006579A (es) | 2009-07-22 |
ATE498620T1 (de) | 2011-03-15 |
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