DE602007004470D1 - Modifiziertes adenovirus-hexon-protein und anwendungen davon - Google Patents

Modifiziertes adenovirus-hexon-protein und anwendungen davon

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Publication number
DE602007004470D1
DE602007004470D1 DE602007004470T DE602007004470T DE602007004470D1 DE 602007004470 D1 DE602007004470 D1 DE 602007004470D1 DE 602007004470 T DE602007004470 T DE 602007004470T DE 602007004470 T DE602007004470 T DE 602007004470T DE 602007004470 D1 DE602007004470 D1 DE 602007004470D1
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Prior art keywords
hexon protein
applications
modified adenovirus
adenovirus hexon
adenovirus
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DE602007004470T
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English (en)
Inventor
Soumitra Roy
James M Wilson
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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DE602007004470T 2006-04-28 2007-04-27 Modifiziertes adenovirus-hexon-protein und anwendungen davon Active DE602007004470D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79607806P 2006-04-28 2006-04-28
PCT/US2007/010347 WO2008010864A2 (en) 2006-04-28 2007-04-27 Modified adenovirus hexon protein and uses thereof

Publications (1)

Publication Number Publication Date
DE602007004470D1 true DE602007004470D1 (de) 2010-03-11

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DE602007004470T Active DE602007004470D1 (de) 2006-04-28 2007-04-27 Modifiziertes adenovirus-hexon-protein und anwendungen davon

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US (3) US20090074810A1 (de)
EP (1) EP2012822B1 (de)
JP (1) JP5889514B2 (de)
CN (1) CN101437538A (de)
AT (1) ATE455558T1 (de)
CY (1) CY1110002T1 (de)
DE (1) DE602007004470D1 (de)
DK (1) DK2012822T3 (de)
ES (1) ES2341501T3 (de)
HR (1) HRP20100228T1 (de)
PL (1) PL2012822T3 (de)
PT (1) PT2012822E (de)
RS (1) RS51250B (de)
SI (1) SI2012822T1 (de)
WO (1) WO2008010864A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4399255B2 (ja) * 2001-06-22 2010-01-13 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 細菌の形質転換体を迅速に選別する方法および新規なサルアデノウイルス蛋白質
CA2466431C (en) * 2001-11-21 2014-08-05 The Trustees Of The University Of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
US7964196B2 (en) 2004-05-25 2011-06-21 Chimeros, Inc. Self-assembling nanoparticle drug delivery system
CA2648581A1 (en) 2006-04-07 2008-09-12 Chimeros, Inc. Compositions and methods for treating b- cell malignancies
BRPI0819783A2 (pt) * 2007-11-28 2015-06-23 Univ Pennsylvania Subfamília simiana e adenovírus sadv-39, -25.2, -26, -30, -37 e -38 e usos dos mesmos.
EP2220217A2 (de) 2007-11-28 2010-08-25 The Trustees of the University of Pennsylvania Simian-adenoviren sadv-40, -31 und-34 der unterfamilie c und anwendungen davon
ES2621165T3 (es) 2007-11-28 2017-07-03 The Trustees Of The University Of Pennsylvania Adenovirus de simio de la subfamilia B SADV-28, -27, -29, -32, -33 y -35 y usos de los mismos
EP2250255A2 (de) 2008-03-04 2010-11-17 The Trustees of the University of Pennsylvania Simian-adenoviren sadv-36, -42.1, -42.2 und -44 sowie anwendungen davon
JP5809978B2 (ja) 2008-10-31 2015-11-11 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア サルアデノウイルスSAdV−43、−45、−46、−47、−48、−49および−50ならびにそれらの用途
WO2010120874A2 (en) 2009-04-14 2010-10-21 Chimeros, Inc. Chimeric therapeutics, compositions, and methods for using same
US8846031B2 (en) 2009-05-29 2014-09-30 The Trustees Of The University Of Pennsylvania Simian adenovirus 41 and uses thereof
JP5903045B2 (ja) 2009-07-31 2016-04-13 パックスバックス, インコーポレイテッド アデノウイルスに基づくベクター
WO2011129468A1 (en) * 2010-04-14 2011-10-20 Mogam Biotechnology Research Institute Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same
EP2643465B1 (de) 2010-11-23 2016-05-11 The Trustees Of The University Of Pennsylvania Affen-adenovirus a1321 der subfamilie e und verwendungen davon
AU2012305714A1 (en) 2011-09-09 2014-03-27 Biomed Realty, L.P. Methods and compositions for controlling assembly of viral proteins
CN103242433B (zh) * 2012-02-14 2016-12-14 中国医学科学院病原生物学研究所 一种腺病毒非结构蛋白免疫原、其抗体及应用
KR20150014505A (ko) 2012-05-18 2015-02-06 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용
EP2946016A4 (de) * 2013-01-15 2016-11-23 Univ California Adenoviren und deren verwendung
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
PL3062815T3 (pl) 2013-11-01 2019-07-31 Pfizer Inc. Wektory do ekspresji antygenów związanych z gruczołem krokowym
CN103865923B (zh) * 2014-01-28 2017-04-26 中国人民解放军第三0二医院 流感病毒为载体的HAdV嵌合疫苗的制备及其应用
EP2940128A1 (de) 2014-04-30 2015-11-04 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Adenovirus mit einem albuminbindenden Teil
WO2015191508A1 (en) 2014-06-09 2015-12-17 Voyager Therapeutics, Inc. Chimeric capsids
JP6401871B2 (ja) 2014-11-05 2018-10-10 ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. パーキンソン病の治療のためのaadcポリヌクレオチド
KR20230169197A (ko) 2014-11-14 2023-12-15 보이저 테라퓨틱스, 인크. 근위축성 측삭 경화증(als)을 치료하는 조성물 및 방법
KR102584655B1 (ko) 2014-11-14 2023-10-06 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
US11697825B2 (en) 2014-12-12 2023-07-11 Voyager Therapeutics, Inc. Compositions and methods for the production of scAAV
US11485791B2 (en) * 2015-03-17 2022-11-01 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies
CA3013637A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
CN117384961A (zh) 2016-02-23 2024-01-12 萨克生物研究学院 对病毒动力学影响最小的治疗性腺病毒中的外源基因表达
EA201891717A1 (ru) * 2016-02-23 2019-02-28 Иммьюн Дизайн Корп. Препараты мультигеномных ретровирусных векторов и способы и системы для их получения и применения
WO2017189959A1 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017189964A2 (en) 2016-04-29 2017-11-02 Voyager Therapeutics, Inc. Compositions for the treatment of disease
WO2017201258A1 (en) 2016-05-18 2017-11-23 Voyager Therapeutics, Inc. Compositions and methods of treating huntington's disease
SG11201809699XA (en) 2016-05-18 2018-12-28 Voyager Therapeutics Inc Modulatory polynucleotides
CN110650673B (zh) 2016-08-30 2024-04-09 加利福尼亚大学董事会 用于生物医学靶向和递送的方法以及用于实践该方法的装置和***
WO2018111767A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
CN106754760A (zh) * 2017-01-20 2017-05-31 华南农业大学 一种嵌合ibdv中和表位的重组人3型腺病毒的制备方法和应用
EP3619308A4 (de) 2017-05-05 2021-01-27 Voyager Therapeutics, Inc. Zusammensetzungen und verfahren zur behandlung von morbus huntington
AU2018261790A1 (en) 2017-05-05 2019-11-28 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
CN111132626B (zh) 2017-07-17 2024-01-30 沃雅戈治疗公司 轨迹阵列引导***
US11434502B2 (en) 2017-10-16 2022-09-06 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (ALS)
US20200237799A1 (en) 2017-10-16 2020-07-30 Voyager Therapeutics, Inc. Treatment of amyotrophic lateral sclerosis (als)
EP3723771A4 (de) * 2017-12-11 2022-04-06 Beth Israel Deaconess Medical Center, Inc. Rekombinante adenoviren und verwendungen davon
WO2020172509A1 (en) * 2019-02-21 2020-08-27 Unleash Immuno Oncolytics, Inc. Oncolytic adenoviral vector and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465253B1 (en) * 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US6083716A (en) * 1996-09-06 2000-07-04 The Trustees Of The University Of Pennsylvania Chimpanzee adenovirus vectors
US6211160B1 (en) * 1996-09-06 2001-04-03 The Trustees Of The University Of Pennsylvania Method for tolerizing a mammalian patient to administration of gene therapy virus vectors
IL141500A0 (en) * 1998-08-27 2002-03-10 Aventis Pharma Sa Targeted adenovirus vectors for delivery of heterologous genes
US6955808B2 (en) * 1999-09-24 2005-10-18 Uab Research Foundation Capsid-modified recombinant adenovirus and methods of use
CA2466431C (en) * 2001-11-21 2014-08-05 The Trustees Of The University Of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
EP1388541A1 (de) * 2002-08-09 2004-02-11 Centre National De La Recherche Scientifique (Cnrs) Pyrrolopyrazine als Kinasehemmer
JP4754480B2 (ja) * 2003-06-20 2011-08-24 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア キメラアデノウイルスの作成法およびそのようなキメラアデノウイルスの使用
US7291498B2 (en) * 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
US7144712B2 (en) * 2003-07-30 2006-12-05 Vaccine Research Institute Of San Diego Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
FR2860004A1 (fr) * 2003-09-18 2005-03-25 Roussy Inst Gustave Nouveau vecteur adenoviral pour l'infection de cellules deficientes ou depourvues en recepteurs car

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DK2012822T3 (da) 2010-05-25
ES2341501T3 (es) 2010-06-21
PL2012822T3 (pl) 2010-06-30
RS51250B (sr) 2010-12-31
US20160102295A1 (en) 2016-04-14
ATE455558T1 (de) 2010-02-15
JP5889514B2 (ja) 2016-03-22
US20170096646A1 (en) 2017-04-06
JP2009535032A (ja) 2009-10-01
PT2012822E (pt) 2010-04-27
WO2008010864A3 (en) 2008-05-02
EP2012822B1 (de) 2010-01-20
SI2012822T1 (sl) 2010-06-30
WO2008010864A2 (en) 2008-01-24
EP2012822A2 (de) 2009-01-14
US20090074810A1 (en) 2009-03-19
CY1110002T1 (el) 2015-01-14
CN101437538A (zh) 2009-05-20

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