DE602006010602D1 - Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes - Google Patents
Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexesInfo
- Publication number
- DE602006010602D1 DE602006010602D1 DE602006010602T DE602006010602T DE602006010602D1 DE 602006010602 D1 DE602006010602 D1 DE 602006010602D1 DE 602006010602 T DE602006010602 T DE 602006010602T DE 602006010602 T DE602006010602 T DE 602006010602T DE 602006010602 D1 DE602006010602 D1 DE 602006010602D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor complex
- benzimidazole derivatives
- gabaa receptor
- modulating
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200501719 | 2005-12-05 | ||
US74253505P | 2005-12-06 | 2005-12-06 | |
DKPA200601326 | 2006-10-12 | ||
US85129106P | 2006-10-13 | 2006-10-13 | |
PCT/EP2006/069237 WO2007065864A1 (en) | 2005-12-05 | 2006-12-04 | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006010602D1 true DE602006010602D1 (de) | 2009-12-31 |
Family
ID=37873123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006010602T Active DE602006010602D1 (de) | 2005-12-05 | 2006-12-04 | Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes |
Country Status (14)
Country | Link |
---|---|
US (1) | US7923464B2 (de) |
EP (1) | EP1996556B1 (de) |
JP (1) | JP2009518292A (de) |
KR (1) | KR20080077620A (de) |
AT (1) | ATE449077T1 (de) |
AU (1) | AU2006324046A1 (de) |
CA (1) | CA2632395A1 (de) |
DE (1) | DE602006010602D1 (de) |
DK (1) | DK1996556T3 (de) |
ES (1) | ES2335438T3 (de) |
IL (1) | IL189974A0 (de) |
NO (1) | NO20083045L (de) |
PL (1) | PL1996556T3 (de) |
WO (1) | WO2007065864A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
EP2231617A1 (de) * | 2007-12-21 | 2010-09-29 | Wyeth LLC | Benzimidazolverbindungen |
CN102036952A (zh) * | 2008-04-16 | 2011-04-27 | 比奥里波克斯公司 | 用作药物的双芳基化合物 |
WO2010039668A2 (en) * | 2008-10-01 | 2010-04-08 | The Regents Of The University Of California | Inhibitors of cyclin kinase inhibitor p21 |
WO2010055127A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
WO2010055125A1 (en) * | 2008-11-14 | 2010-05-20 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the gabaa receptor complex |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK40192D0 (da) | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
CZ287545B6 (en) | 1995-04-21 | 2000-12-13 | Neurosearch As | Benzimidazole derivatives, pharmaceutical preparation in which they are comprised and their use |
JP2001502675A (ja) | 1996-10-21 | 2001-02-27 | ニューロサーチ・アクティーゼルスカブ | 1―フエニル―ベンズイミダゾール化合物及びこれをbaga▲下a▼―レセプターモデュレーターとして使用する方法 |
WO1999019323A1 (en) | 1997-10-10 | 1999-04-22 | Neurosearch A/S | Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use |
WO2000078728A1 (en) | 1999-06-22 | 2000-12-28 | Neurosearch A/S | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
WO2002050057A1 (en) | 2000-12-20 | 2002-06-27 | Neurosearch A/S | Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders |
EP1613618A2 (de) | 2003-04-03 | 2006-01-11 | Neurosearch A/S | Benzimidazol derivate und ihre verwendung als modulatoren des gaba-a rezeptoren komplexes |
US7335777B2 (en) * | 2003-04-03 | 2008-02-26 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAA receptor complex |
AP2006003549A0 (en) | 2003-08-21 | 2006-04-30 | Osi Pharm Inc | N-substituted benzimidazolyl C-kit inhibitors. |
JP2007509108A (ja) | 2003-10-23 | 2007-04-12 | アクゾ ノベル ナムローゼ フェンノートシャップ | 1,5,7−三置換ベンズイミダゾール誘導体及びgabaa受容体複合体を調節するためのその使用 |
BRPI0518794A2 (pt) | 2004-12-01 | 2008-12-09 | Osi Pharm Inc | composto, composiÇço, mÉtodo de tratamento de distérbio hiperproliferativo, e, biblioteca combinatorial |
EP1877052B1 (de) | 2005-04-13 | 2009-07-22 | Neurosearch A/S | Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes |
EP1874758A1 (de) * | 2005-04-19 | 2008-01-09 | Neurosearch A/S | Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes |
TWI391381B (zh) | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
-
2006
- 2006-12-04 DE DE602006010602T patent/DE602006010602D1/de active Active
- 2006-12-04 AU AU2006324046A patent/AU2006324046A1/en not_active Abandoned
- 2006-12-04 EP EP06830303A patent/EP1996556B1/de not_active Not-in-force
- 2006-12-04 KR KR1020087013766A patent/KR20080077620A/ko not_active Application Discontinuation
- 2006-12-04 ES ES06830303T patent/ES2335438T3/es active Active
- 2006-12-04 DK DK06830303.1T patent/DK1996556T3/da active
- 2006-12-04 US US12/085,769 patent/US7923464B2/en not_active Expired - Fee Related
- 2006-12-04 AT AT06830303T patent/ATE449077T1/de active
- 2006-12-04 JP JP2008542778A patent/JP2009518292A/ja not_active Abandoned
- 2006-12-04 WO PCT/EP2006/069237 patent/WO2007065864A1/en active Application Filing
- 2006-12-04 CA CA002632395A patent/CA2632395A1/en not_active Abandoned
- 2006-12-04 PL PL06830303T patent/PL1996556T3/pl unknown
-
2008
- 2008-03-06 IL IL189974A patent/IL189974A0/en unknown
- 2008-07-04 NO NO20083045A patent/NO20083045L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1996556A1 (de) | 2008-12-03 |
EP1996556B1 (de) | 2009-11-18 |
KR20080077620A (ko) | 2008-08-25 |
PL1996556T3 (pl) | 2010-05-31 |
WO2007065864A1 (en) | 2007-06-14 |
NO20083045L (no) | 2008-09-04 |
IL189974A0 (en) | 2008-08-07 |
JP2009518292A (ja) | 2009-05-07 |
US20090048321A1 (en) | 2009-02-19 |
US7923464B2 (en) | 2011-04-12 |
ATE449077T1 (de) | 2009-12-15 |
AU2006324046A1 (en) | 2007-06-14 |
ES2335438T3 (es) | 2010-03-26 |
DK1996556T3 (da) | 2010-04-06 |
CA2632395A1 (en) | 2007-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |