DE602005020049D1 - Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie - Google Patents
Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographieInfo
- Publication number
- DE602005020049D1 DE602005020049D1 DE602005020049T DE602005020049T DE602005020049D1 DE 602005020049 D1 DE602005020049 D1 DE 602005020049D1 DE 602005020049 T DE602005020049 T DE 602005020049T DE 602005020049 T DE602005020049 T DE 602005020049T DE 602005020049 D1 DE602005020049 D1 DE 602005020049D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrocodone
- preparative chromatography
- column
- separating
- cleaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/287—Non-polar phases; Reversed phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62243004P | 2004-10-27 | 2004-10-27 | |
PCT/US2005/038603 WO2006052456A1 (en) | 2004-10-27 | 2005-10-26 | Method for separation and purification of hydrocodone by preparative chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005020049D1 true DE602005020049D1 (de) | 2010-04-29 |
Family
ID=35833523
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005020049T Active DE602005020049D1 (de) | 2004-10-27 | 2005-10-26 | Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie |
Country Status (11)
Country | Link |
---|---|
US (1) | US7692013B2 (de) |
EP (1) | EP1807433B1 (de) |
JP (1) | JP2008518237A (de) |
CN (1) | CN101065384A (de) |
AT (1) | ATE461199T1 (de) |
AU (1) | AU2005305236A1 (de) |
CA (1) | CA2585533A1 (de) |
DE (1) | DE602005020049D1 (de) |
ES (1) | ES2341121T3 (de) |
MX (1) | MX2007004855A (de) |
WO (1) | WO2006052456A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2621943A1 (en) * | 2005-03-11 | 2006-09-21 | Noramco, Inc. | Hydrocodone polymorphs |
US7625918B2 (en) | 2005-03-11 | 2009-12-01 | Noramco, Inc. | Hydrocodone polymorphs |
US8492547B2 (en) * | 2009-07-09 | 2013-07-23 | Mallinckrodt Llc | Method for the enrichment of buprenorphine using chromatographic techniques |
KR102196230B1 (ko) | 2012-09-17 | 2020-12-29 | 더블유.알. 그레이스 앤드 캄파니-콘. | 크로마토그래피 매질 및 장치 |
PL3094390T3 (pl) | 2014-01-16 | 2021-12-06 | W.R. Grace & Co. - Conn. | Nośniki do chromatografii powinowactwa i urządzenia do chromatografii |
ES2929099T3 (es) | 2014-05-02 | 2022-11-24 | Grace W R & Co | Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado |
JP2018517559A (ja) | 2015-06-05 | 2018-07-05 | ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn | 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法 |
CN107304213B (zh) * | 2016-04-20 | 2021-08-20 | 李显林 | 一种罂粟提取物处理方法及设备 |
WO2018009856A1 (en) | 2016-07-08 | 2018-01-11 | Cody Laboratories, Inc. | Method for catalytic preparation of hydromorphone, hydrocodone and other opiates |
US20220395767A1 (en) * | 2021-06-15 | 2022-12-15 | Perkinelmer Health Sciences, Inc. | Enhancing lcms analyte signals |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2715626A (en) * | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
US4241065A (en) * | 1979-07-02 | 1980-12-23 | E. I. Du Pont De Nemours And Company | Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both |
DE69325096T2 (de) * | 1992-04-06 | 1999-09-30 | Biosite Diagnostics Inc., San Diego | Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden |
GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
US5677279A (en) * | 1996-12-16 | 1997-10-14 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating pain with amylin or agonists thereof |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
US6359111B1 (en) * | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
GB9904786D0 (en) * | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
AU2001282875A1 (en) * | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002030542A2 (en) * | 2000-10-12 | 2002-04-18 | Robert Corcoran | Purification of substance by reaction affinity chromatography |
JP2005522460A (ja) | 2002-02-28 | 2005-07-28 | マリンクロッド・インコーポレイテッド | 逆相分取用クロマトグラフィーを用いる少なくとも1種の麻薬性アルカロイドの分離および精製のための方法およびシステム |
US7226925B2 (en) * | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
US7629355B2 (en) * | 2003-10-14 | 2009-12-08 | Lawson John A | Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives |
-
2005
- 2005-10-26 WO PCT/US2005/038603 patent/WO2006052456A1/en active Application Filing
- 2005-10-26 MX MX2007004855A patent/MX2007004855A/es not_active Application Discontinuation
- 2005-10-26 ES ES05820862T patent/ES2341121T3/es active Active
- 2005-10-26 EP EP05820862A patent/EP1807433B1/de not_active Not-in-force
- 2005-10-26 CN CNA2005800408984A patent/CN101065384A/zh active Pending
- 2005-10-26 US US11/576,059 patent/US7692013B2/en not_active Expired - Fee Related
- 2005-10-26 AT AT05820862T patent/ATE461199T1/de not_active IP Right Cessation
- 2005-10-26 JP JP2007539074A patent/JP2008518237A/ja not_active Withdrawn
- 2005-10-26 AU AU2005305236A patent/AU2005305236A1/en not_active Abandoned
- 2005-10-26 CA CA002585533A patent/CA2585533A1/en not_active Abandoned
- 2005-10-26 DE DE602005020049T patent/DE602005020049D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
WO2006052456A1 (en) | 2006-05-18 |
MX2007004855A (es) | 2007-06-13 |
EP1807433A1 (de) | 2007-07-18 |
EP1807433B1 (de) | 2010-03-17 |
JP2008518237A (ja) | 2008-05-29 |
AU2005305236A1 (en) | 2006-05-18 |
US7692013B2 (en) | 2010-04-06 |
CA2585533A1 (en) | 2006-05-18 |
CN101065384A (zh) | 2007-10-31 |
US20070293676A1 (en) | 2007-12-20 |
ES2341121T3 (es) | 2010-06-15 |
ATE461199T1 (de) | 2010-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602005020049D1 (de) | Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie | |
BRPI0518207A (pt) | método de separação de um ou mais anticorpos de um ou mais outros compostos em uma amostra lìquida, kits para a purificação de anticorpos de um ou mais outros componentes em um lìquido, e para a captura de anticorpos de um ou mais outros componentes em um lìquido, coluna de cromatografia, e, filtro descartável para a purificação de anticorpos | |
Mosiashvili et al. | On the effect of basic and acidic additives on the separation of the enantiomers of some basic drugs with polysaccharide-based chiral selectors and polar organic mobile phases | |
Voitl et al. | Application of mixed mode resins for the purification of antibodies | |
US9073970B2 (en) | Chromatographic process for enrichment and isolation | |
HK1136305A1 (en) | Solid phase for use in a method for the purification of albumin conjugates | |
Hamman et al. | A high throughput approach to purifying chiral molecules using 3 μm analytical chiral stationary phases via supercritical fluid chromatography | |
ES2155477T3 (es) | Purificacion cromatografica y procedimiento de separacion de acidos nucleicos. | |
MX264489B (en) | Industrial method for separation and purification of fentanyl by reverse phase preparative chromatography | |
GB2441919A (en) | Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography | |
WO2007052303A3 (en) | Process for production of chlorinated sucrose based on hydrophobic affinity chromatography. | |
WO2005026323A3 (en) | Stationary phases and a purification process using the stationary phases | |
Curran | Separations with fluorous silica gel and related materials | |
ATE509989T1 (de) | Adsorber mit anthrachinonfarbstoffliganden zur trennung von biologischen stoffen | |
Kastler et al. | Group separation of organic nitrates on a new nitric acid ester NP-LC stationary phase | |
JP2007509945A5 (de) | ||
SE9201976D0 (sv) | En metod foer att adsorbera proteiner och peptider till hydrofoba zeoliter | |
Mant et al. | Preparative Reversed-Phase Sample Displacement Chromatography of Synthetic Peptides | |
de Veredas et al. | Continuous chromatographic separation of a baclofen precursor (N-Boc-4-[p-chloro-phenyl]-2-pyrrolidone) in a simulated moving bed using a polysaccharide carbamate as chiral stationary phase | |
WO2008067271A3 (en) | Prevention of leaching of ligands from affinity-based purification systems | |
Gerstner | Cleaner separations | |
AMOUZADEH | Gypsum as a Good Stationary Phase for Separation of Some Organic Compounds in Chromatography | |
JPH1144678A (ja) | フタル酸エステル類の分析法 | |
Kennedy et al. | Development of analytical and preparative chromatographic separations of novel growth hormone secretagogue compounds | |
Lewis | The use of porous glass beads in the separation and purification of ruthenium complexes with large organic ligands |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |