DE602005020049D1 - Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie - Google Patents

Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie

Info

Publication number
DE602005020049D1
DE602005020049D1 DE602005020049T DE602005020049T DE602005020049D1 DE 602005020049 D1 DE602005020049 D1 DE 602005020049D1 DE 602005020049 T DE602005020049 T DE 602005020049T DE 602005020049 T DE602005020049 T DE 602005020049T DE 602005020049 D1 DE602005020049 D1 DE 602005020049D1
Authority
DE
Germany
Prior art keywords
hydrocodone
preparative chromatography
column
separating
cleaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005020049T
Other languages
English (en)
Inventor
Enrico A Antonini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE602005020049D1 publication Critical patent/DE602005020049D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/287—Non-polar phases; Reversed phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE602005020049T 2004-10-27 2005-10-26 Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie Active DE602005020049D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62243004P 2004-10-27 2004-10-27
PCT/US2005/038603 WO2006052456A1 (en) 2004-10-27 2005-10-26 Method for separation and purification of hydrocodone by preparative chromatography

Publications (1)

Publication Number Publication Date
DE602005020049D1 true DE602005020049D1 (de) 2010-04-29

Family

ID=35833523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005020049T Active DE602005020049D1 (de) 2004-10-27 2005-10-26 Verfahren zur trennung und reinigung von hydrocodon durch präparative chromatographie

Country Status (11)

Country Link
US (1) US7692013B2 (de)
EP (1) EP1807433B1 (de)
JP (1) JP2008518237A (de)
CN (1) CN101065384A (de)
AT (1) ATE461199T1 (de)
AU (1) AU2005305236A1 (de)
CA (1) CA2585533A1 (de)
DE (1) DE602005020049D1 (de)
ES (1) ES2341121T3 (de)
MX (1) MX2007004855A (de)
WO (1) WO2006052456A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2621943A1 (en) * 2005-03-11 2006-09-21 Noramco, Inc. Hydrocodone polymorphs
US7625918B2 (en) 2005-03-11 2009-12-01 Noramco, Inc. Hydrocodone polymorphs
US8492547B2 (en) * 2009-07-09 2013-07-23 Mallinckrodt Llc Method for the enrichment of buprenorphine using chromatographic techniques
KR102196230B1 (ko) 2012-09-17 2020-12-29 더블유.알. 그레이스 앤드 캄파니-콘. 크로마토그래피 매질 및 장치
PL3094390T3 (pl) 2014-01-16 2021-12-06 W.R. Grace & Co. - Conn. Nośniki do chromatografii powinowactwa i urządzenia do chromatografii
ES2929099T3 (es) 2014-05-02 2022-11-24 Grace W R & Co Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado
JP2018517559A (ja) 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
CN107304213B (zh) * 2016-04-20 2021-08-20 李显林 一种罂粟提取物处理方法及设备
WO2018009856A1 (en) 2016-07-08 2018-01-11 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone and other opiates
US20220395767A1 (en) * 2021-06-15 2022-12-15 Perkinelmer Health Sciences, Inc. Enhancing lcms analyte signals

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715626A (en) * 1950-07-05 1955-08-16 Merck & Co Inc Process of preparing dihydrocodeinone
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
DE69325096T2 (de) * 1992-04-06 1999-09-30 Biosite Diagnostics Inc., San Diego Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
US5677279A (en) * 1996-12-16 1997-10-14 Amylin Pharmaceuticals, Inc. Methods and compositions for treating pain with amylin or agonists thereof
GB9717629D0 (en) * 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
GB9904786D0 (en) * 1999-03-02 1999-04-28 Merck Sharp & Dohme Therapeutic agents
AU2001282875A1 (en) * 2000-08-21 2002-03-04 Pharmacia And Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002030542A2 (en) * 2000-10-12 2002-04-18 Robert Corcoran Purification of substance by reaction affinity chromatography
JP2005522460A (ja) 2002-02-28 2005-07-28 マリンクロッド・インコーポレイテッド 逆相分取用クロマトグラフィーを用いる少なくとも１種の麻薬性アルカロイドの分離および精製のための方法およびシステム
US7226925B2 (en) * 2002-06-19 2007-06-05 Biovitrum Ab Compounds, their use and preparation
US7629355B2 (en) * 2003-10-14 2009-12-08 Lawson John A Treatment of chemical dependency with substantially nonaddicting normorphine and norcodeine derivatives

Also Published As

Publication number Publication date
WO2006052456A1 (en) 2006-05-18
MX2007004855A (es) 2007-06-13
EP1807433A1 (de) 2007-07-18
EP1807433B1 (de) 2010-03-17
JP2008518237A (ja) 2008-05-29
AU2005305236A1 (en) 2006-05-18
US7692013B2 (en) 2010-04-06
CA2585533A1 (en) 2006-05-18
CN101065384A (zh) 2007-10-31
US20070293676A1 (en) 2007-12-20
ES2341121T3 (es) 2010-06-15
ATE461199T1 (de) 2010-04-15

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