DE602005017099D1 - Verfahren zur Herstellung von amorphem Cefuroximaxetil - Google Patents

Verfahren zur Herstellung von amorphem Cefuroximaxetil

Info

Publication number
DE602005017099D1
DE602005017099D1 DE602005017099T DE602005017099T DE602005017099D1 DE 602005017099 D1 DE602005017099 D1 DE 602005017099D1 DE 602005017099 T DE602005017099 T DE 602005017099T DE 602005017099 T DE602005017099 T DE 602005017099T DE 602005017099 D1 DE602005017099 D1 DE 602005017099D1
Authority
DE
Germany
Prior art keywords
preparation
cefuroximaxetil
amorphous
amorphous cefuroximaxetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602005017099T
Other languages
English (en)
Inventor
Jianfeng Chen
Jie Zhong
Zhigang Shen
Jiyado Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing University of Chemical Technology
Nanomaterials Technology Pte Ltd
Original Assignee
Beijing University of Chemical Technology
Nanomaterials Technology Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing University of Chemical Technology, Nanomaterials Technology Pte Ltd filed Critical Beijing University of Chemical Technology
Publication of DE602005017099D1 publication Critical patent/DE602005017099D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005017099T 2004-07-22 2005-07-14 Verfahren zur Herstellung von amorphem Cefuroximaxetil Expired - Fee Related DE602005017099D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2004100693980A CN100448879C (zh) 2004-07-22 2004-07-22 一种无定型头孢呋辛酯的制备方法

Publications (1)

Publication Number Publication Date
DE602005017099D1 true DE602005017099D1 (de) 2009-11-26

Family

ID=34666780

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017099T Expired - Fee Related DE602005017099D1 (de) 2004-07-22 2005-07-14 Verfahren zur Herstellung von amorphem Cefuroximaxetil

Country Status (4)

Country Link
US (1) US7507813B2 (de)
EP (1) EP1619198B1 (de)
CN (1) CN100448879C (de)
DE (1) DE602005017099D1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006019619A1 (de) * 2006-04-25 2007-10-31 Grünenthal GmbH Kristalline Modifikation von Cefuroximaxetil
CN100448447C (zh) * 2007-03-08 2009-01-07 北京化工大学 一种制备超细***龙粉体的方法
US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
WO2017046756A1 (en) * 2015-09-18 2017-03-23 Lupin Limited Proxetil and axetil esters of cefixime
CN106265542A (zh) * 2016-09-22 2017-01-04 北京化工大学 一种阿霉素纳米药物颗粒的制备方法
CN108210468B (zh) * 2016-12-22 2019-10-29 北京化工大学 一种甲苯磺酸索拉非尼口服纳米制剂的制备方法
CN108586493A (zh) * 2017-12-18 2018-09-28 蚌埠丰原医药科技发展有限公司 一种结晶型头孢呋辛酯的制备方法
CN109956959A (zh) * 2019-04-30 2019-07-02 华北制药股份有限公司 一种7-苯乙酰氨基去乙酰氧基头孢g酸及其制备方法
CN114195608B (zh) * 2021-11-08 2023-03-31 北京化工大学 一种Suzuki反应单体的纯化方法
CN114354800B (zh) * 2021-12-31 2023-04-28 山东大学 头孢呋辛酯中乙酰溴含量的分析方法
CN115724773A (zh) * 2022-12-05 2023-03-03 宁夏东吴农化股份有限公司 一种超重力水解结晶法制备超细硝基胍的方法
CN116284050B (zh) * 2022-12-19 2024-04-12 华北制药河北华民药业有限责任公司 一种高效率结晶型头孢呋辛酯转无定型粉体的方法及产品

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1571683A (en) 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
CN1020036C (zh) 1991-10-08 1993-03-10 北京化工学院 旋转床超重力场强化传递与反应装置
CN1021546C (zh) 1992-01-16 1993-07-14 北京化工学院 带有抽吸装置的旋转床超重力场装置
TW293010B (en) * 1994-04-20 1996-12-11 Hui-Po Wang Method for preparing cephalosporin derivatives
CN1038578C (zh) 1995-05-26 1998-06-03 北京化工大学 超细碳酸钙的制备方法
CN1036766C (zh) 1995-07-06 1997-12-24 北京化工大学 错流旋转床超重力场装置
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
CN1111537C (zh) * 1997-05-15 2003-06-18 第一制糖株式会社 高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
IN186539B (de) * 1997-09-29 2001-09-29 Ranbaxy Lab Ltd
US6384213B1 (en) * 1998-10-23 2002-05-07 Ranbaxy Laboratories Limited Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
IN190831B (de) * 1999-03-19 2003-08-23 Ranbaxy Lab Ltd
CN1112320C (zh) 2000-01-18 2003-06-25 北京化工大学 一种连续法制备沉淀碳酸钙的方法
IN190849B (de) * 2000-07-17 2003-08-23 Ranbaxy Lab Ltd
IL154168A0 (en) * 2000-08-22 2003-07-31 Ribapharm Inc Improved specificity in treatment of diseases
KR20020016052A (ko) * 2000-08-24 2002-03-04 최현식 무정형 세푸록심 악세틸의 제조방법
CN1095483C (zh) 2000-10-16 2002-12-04 北京化工大学 纳米碳酸钙塑料增韧母料
WO2003010170A1 (en) * 2001-07-25 2003-02-06 Lupin Limited An improved method for preparation of cefuroxime axetil
ITMI20011763A1 (it) * 2001-08-10 2003-02-10 Antibioticos Spa Processo di preparazione di cefuroxime axelite ad elevata purezza
ITMI20011925A1 (it) * 2001-09-14 2003-03-14 Antibioticos Spa Metodo applicabile su scala industriale per la preparazione di cefuroxime axetile cristallino
CN1326860C (zh) 2002-08-06 2007-07-18 北京化工大学 头孢拉定晶体以及制备头孢拉定的方法

Also Published As

Publication number Publication date
US7507813B2 (en) 2009-03-24
EP1619198A1 (de) 2006-01-25
CN100448879C (zh) 2009-01-07
US20060020130A1 (en) 2006-01-26
EP1619198B1 (de) 2009-10-14
CN1600785A (zh) 2005-03-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee