DE602005015893D1 - Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression - Google Patents

Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression

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Publication number
DE602005015893D1
DE602005015893D1 DE602005015893T DE602005015893T DE602005015893D1 DE 602005015893 D1 DE602005015893 D1 DE 602005015893D1 DE 602005015893 T DE602005015893 T DE 602005015893T DE 602005015893 T DE602005015893 T DE 602005015893T DE 602005015893 D1 DE602005015893 D1 DE 602005015893D1
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Prior art keywords
prognosis
analysis
nucleic acids
proliferation
gene expression
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DE602005015893T
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English (en)
Inventor
Susan Cottrell
Fabian Model
Carolina Haefliger
Gunter Weiss
Juergen Distler
Andrew Z Sledziewski
Xiaoling Song
Thomas L Skillman
Jeffrey G Thomas
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Epigenomics AG
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Epigenomics AG
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Publication of DE602005015893D1 publication Critical patent/DE602005015893D1/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005015893T 2004-12-02 2005-12-02 Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression Active DE602005015893D1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US63325004P 2004-12-02 2004-12-02
US63242604P 2004-12-02 2004-12-02
US66222005P 2005-03-14 2005-03-14
US72305405P 2005-10-03 2005-10-03
US72312505P 2005-10-03 2005-10-03
US74073605P 2005-11-30 2005-11-30
PCT/US2005/043974 WO2006071466A2 (en) 2004-12-02 2005-12-02 Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders

Publications (1)

Publication Number Publication Date
DE602005015893D1 true DE602005015893D1 (de) 2009-09-17

Family

ID=39661458

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005015893T Active DE602005015893D1 (de) 2004-12-02 2005-12-02 Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression

Country Status (9)

Country Link
US (2) US20090197250A1 (de)
EP (5) EP2311984A1 (de)
JP (2) JP5745202B2 (de)
AT (1) ATE438740T1 (de)
AU (1) AU2005322435B2 (de)
CA (1) CA2593546A1 (de)
DE (1) DE602005015893D1 (de)
ES (2) ES2331146T3 (de)
WO (1) WO2006071466A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
WO2006113466A2 (en) * 2005-04-15 2006-10-26 Epigenomics Ag. Methods and nucleic acids for analyses of cellular proliferative disorders
US10053735B2 (en) * 2005-09-21 2018-08-21 Therawis Diagnostics Gmbh Markers for the prediction of outcome of anthracycline treatment
WO2007039290A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
WO2007039291A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods, apparatus and nomograms to determine prostate cancer progression
US7770717B2 (en) * 2005-10-12 2010-08-10 Scanvaegt International A/S Device for transfer of items
WO2007060671A2 (en) * 2005-11-27 2007-05-31 Compugen Ltd. Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
US20090062645A1 (en) * 2007-09-03 2009-03-05 Jens Fehre Method for diagnosis and treatment of prostate cancer
CA2706604A1 (en) * 2007-11-23 2009-05-28 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
CA2708163A1 (en) * 2007-12-11 2009-06-18 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
US8841268B2 (en) * 2008-05-07 2014-09-23 Sapporo Medical University Method and kit for detection of cancer, and therapeutic agent for cancer
US9315802B2 (en) 2009-12-30 2016-04-19 Quest Diagnostics Investments Incorporated RNA isolation from soluble urine fractions
DE102010028105A1 (de) * 2010-04-22 2011-10-27 Siemens Aktiengesellschaft Verfahren, Vorrichtung und Gerätesystem für die Therapie von Prostatakrebs
US9663781B2 (en) 2010-12-30 2017-05-30 Quest Diagnostics Investments Incorporated Diagnosis of prostate cancer
EP2514836B1 (de) * 2011-04-19 2016-06-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Prostatakrebsmarker
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
KR101467289B1 (ko) * 2013-01-22 2014-12-02 한국원자력의학원 Wdfy3를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도
US20150010518A1 (en) * 2013-07-03 2015-01-08 The University Of British Columbia Nr2e1 mini-promoters
WO2015023285A1 (en) * 2013-08-15 2015-02-19 Xia Xueliang James Biomarkers for use in colorectal cancer
JP6427750B2 (ja) * 2013-10-02 2018-11-28 コニカミノルタ株式会社 Cxcl1、ならびにsmoxおよび/またはid1の発現量に基づく肺癌患者の予後を判定するためのデータ収集方法およびキット
GB2524948A (en) * 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
GB201404998D0 (en) * 2014-03-20 2014-05-07 Univ Birmingham Atrial fibrillation therapy
EP3037545A1 (de) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin DNS-Methylierungstest auf Prostatakrebs
EP3246415A1 (de) * 2016-05-18 2017-11-22 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Verfahren zur prognose von prostatakrebs
US11705230B1 (en) 2021-11-30 2023-07-18 Vignet Incorporated Assessing health risks using genetic, epigenetic, and phenotypic data sources
US11901083B1 (en) 2021-11-30 2024-02-13 Vignet Incorporated Using genetic and phenotypic data sets for drug discovery clinical trials
CN114015771A (zh) * 2022-01-05 2022-02-08 北京华诺奥美基因医学检验实验室有限公司 一种snrpn父源缺失的检测引物组、试剂盒及非诊断目的的检测方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5245022A (en) 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
JPH09506253A (ja) 1993-11-30 1997-06-24 マクギル・ユニヴァーシティ Dnaメチルトランスフェラーゼの阻害
US5597696A (en) * 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5514758A (en) 1994-09-30 1996-05-07 The Goodyear Tire & Rubber Company Process for making latex for high performance masking tape
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
US6331393B1 (en) 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
AU2002214576A1 (en) * 2000-10-13 2002-04-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genes related to development of refractory prostate cancer
CA2439779A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions based on their effect on the methylation status of the dna
CA2439854A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
WO2002077895A2 (en) * 2001-03-26 2002-10-03 Epigenomics Ag Method for epigenetic feature selection
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US20060024684A1 (en) * 2002-10-01 2006-02-02 Epigenomics Ag Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
JP4649331B2 (ja) * 2002-10-01 2011-03-09 エピゲノミクス アーゲー ***細胞増殖障害の改良治療方法および核酸
SE524468C2 (sv) * 2002-12-09 2004-08-10 Axlon Int Ab Anordning och metod för sortering av mynt
US20040146868A1 (en) * 2003-01-24 2004-07-29 Epigenomics Ag Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer
EP1689889B1 (de) 2003-12-01 2017-08-30 Epigenomics AG Verfahren und nukleinsäuren zur analyse der mit der entwicklung von prostatazellproliferationsstörungen assoziierten genexpression
US9017944B2 (en) 2003-12-11 2015-04-28 Epigenomics Ag Methods for the prognosis of breast cancer
DE602007014278D1 (de) * 2006-02-28 2011-06-16 Charite Universitaetsmedizin Nachweis und Qualitätskontrolle von Regulator-T-Zellen mittels DNA-Methylierungsanalyse des FoxP3-Gens

Also Published As

Publication number Publication date
US20090197250A1 (en) 2009-08-06
EP1831399B1 (de) 2009-08-05
EP2284279A1 (de) 2011-02-16
EP2213749A1 (de) 2010-08-04
JP5883677B2 (ja) 2016-03-15
EP2280084B1 (de) 2015-02-11
JP2012120538A (ja) 2012-06-28
AU2005322435A1 (en) 2006-07-06
WO2006071466A2 (en) 2006-07-06
AU2005322435B2 (en) 2012-02-23
WO2006071466A3 (en) 2007-03-15
JP5745202B2 (ja) 2015-07-08
EP1831399A2 (de) 2007-09-12
ATE438740T1 (de) 2009-08-15
EP2311984A1 (de) 2011-04-20
WO2006071466A8 (en) 2009-06-18
JP2008522590A (ja) 2008-07-03
CA2593546A1 (en) 2006-07-06
ES2534139T3 (es) 2015-04-17
US20160312287A1 (en) 2016-10-27
ES2331146T3 (es) 2009-12-22
EP2280084A1 (de) 2011-02-02
EP2311984A8 (de) 2011-12-28

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