DE602004024394D1 - Feedback-resistente acetohydroxysäure-synthetase-mutanten - Google Patents

Feedback-resistente acetohydroxysäure-synthetase-mutanten

Info

Publication number
DE602004024394D1
DE602004024394D1 DE602004024394T DE602004024394T DE602004024394D1 DE 602004024394 D1 DE602004024394 D1 DE 602004024394D1 DE 602004024394 T DE602004024394 T DE 602004024394T DE 602004024394 T DE602004024394 T DE 602004024394T DE 602004024394 D1 DE602004024394 D1 DE 602004024394D1
Authority
DE
Germany
Prior art keywords
nucleic acid
polypeptide
sequence
acid sequences
cited above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004024394T
Other languages
English (en)
Inventor
Miroslav Patek
Veronika Elisakova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Evonik Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa GmbH filed Critical Evonik Degussa GmbH
Publication of DE602004024394D1 publication Critical patent/DE602004024394D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE602004024394T 2003-06-26 2004-06-08 Feedback-resistente acetohydroxysäure-synthetase-mutanten Expired - Fee Related DE602004024394D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20030014640 EP1491634A1 (de) 2003-06-26 2003-06-26 Feedback resistente Acetohydroxysäure-Synthetase Mutanten
PCT/EP2004/006157 WO2005003357A1 (en) 2003-06-26 2004-06-08 Feedback resistant acetohydroxy acid synthethase mutants

Publications (1)

Publication Number Publication Date
DE602004024394D1 true DE602004024394D1 (en) 2010-01-14

Family

ID=33395884

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004024394T Expired - Fee Related DE602004024394D1 (en) 2003-06-26 2004-06-08 Feedback-resistente acetohydroxysäure-synthetase-mutanten

Country Status (11)

Country Link
US (2) US7585959B2 (de)
EP (2) EP1491634A1 (de)
JP (1) JP2007506407A (de)
KR (1) KR20060024437A (de)
CN (1) CN100523197C (de)
AT (1) ATE450611T1 (de)
BR (1) BRPI0411975A (de)
DE (1) DE602004024394D1 (de)
RU (1) RU2325439C2 (de)
WO (1) WO2005003357A1 (de)
ZA (1) ZA200510448B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2355763C2 (ru) * 2006-09-13 2009-05-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная ацетолактатсинтаза и способ продукции разветвленных l-аминокислот
WO2012014228A1 (en) 2010-07-28 2012-02-02 Abhishek Narain Singh A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation
DE102011118019A1 (de) 2011-06-28 2013-01-03 Evonik Degussa Gmbh Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens
EP2811028B1 (de) 2013-06-03 2017-02-01 Evonik Degussa GmbH Verfahren zur Herstellung von L-Valin unter Verwendung rekombinanter Corynebakterien enthaltend das durch Propionat induzierbare ilvBN-Operon
KR101720836B1 (ko) 2014-08-05 2017-04-03 씨제이제일제당 (주) 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법
CN105886431B (zh) * 2016-04-27 2019-05-10 天津科技大学 一株谷氨酸棒状杆菌及其高产异亮氨酸的方法
WO2017194696A1 (en) 2016-05-12 2017-11-16 Danmarks Tekniske Universitet Bacterial cells with improved tolerance to isobutyric acid
US11021697B2 (en) 2017-07-11 2021-06-01 Cj Cheiljedang Corporation Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
KR101996129B1 (ko) 2017-07-11 2019-07-04 씨제이제일제당 (주) 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
CN113195711A (zh) * 2018-12-12 2021-07-30 株式会社Co2资源化研究所 具有增强的产缬氨酸能力的嗜氢菌属细菌基因重组体
CN110229797B (zh) * 2019-06-05 2020-08-28 天津科技大学 一种乙酰羟酸合成酶及其应用
KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물
KR20230045990A (ko) * 2021-09-29 2023-04-05 씨제이제일제당 (주) 신규한 아세토하이드록시산 신테아제 변이체 및 이를 이용한 l-이소류신 생산방법
AU2022357997A1 (en) * 2021-09-29 2024-04-18 Cj Cheiljedang Corporation Novel acetohydroxy acid synthase variant, and method for producing l-isoleucine using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2748418B2 (ja) * 1988-08-03 1998-05-06 味の素株式会社 組換えｄｎａ、該組換えｄｎａを有する微生物
DE3942947A1 (de) * 1989-12-23 1991-06-27 Forschungszentrum Juelich Gmbh Verfahren zur herstellung von l-isoleucin und dafuer geeignete mikroorganismen und rekombinante dna
JP4623825B2 (ja) * 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
RU2209246C2 (ru) * 2000-01-26 2003-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Малая субъединица изозима iii и изозим iii синтетазы ацетогидроксикислот из escherichia coli, фрагмент днк (варианты), штамм бактерии escherichia coli - продуцент l-валина (варианты) и способ получения l-валина
US6965021B2 (en) * 2000-10-13 2005-11-15 Archer-Daniels-Midland Company Feedback-resistant pyruvate carboxylase gene from corynebacterium

Also Published As

Publication number Publication date
JP2007506407A (ja) 2007-03-22
RU2325439C2 (ru) 2008-05-27
KR20060024437A (ko) 2006-03-16
ATE450611T1 (de) 2009-12-15
EP1491634A1 (de) 2004-12-29
EP1636366A1 (de) 2006-03-22
ZA200510448B (en) 2006-12-27
US7585959B2 (en) 2009-09-08
WO2005003357A1 (en) 2005-01-13
CN1813065A (zh) 2006-08-02
EP1636366B1 (de) 2009-12-02
BRPI0411975A (pt) 2006-08-29
RU2006102024A (ru) 2006-09-10
US20070292914A1 (en) 2007-12-20
US20100086966A1 (en) 2010-04-08
CN100523197C (zh) 2009-08-05

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