DE602004024038D1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren - Google Patents

Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren

Info

Publication number
DE602004024038D1
DE602004024038D1 DE602004024038T DE602004024038T DE602004024038D1 DE 602004024038 D1 DE602004024038 D1 DE 602004024038D1 DE 602004024038 T DE602004024038 T DE 602004024038T DE 602004024038 T DE602004024038 T DE 602004024038T DE 602004024038 D1 DE602004024038 D1 DE 602004024038D1
Authority
DE
Germany
Prior art keywords
compositions
multichromophores
collecting
detecting
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004024038T
Other languages
English (en)
Inventor
Guillermo Bazan
Bin Liu
Shu Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE602004024038D1 publication Critical patent/DE602004024038D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Peptides Or Proteins (AREA)
DE602004024038T 2003-02-13 2004-02-13 Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren Expired - Lifetime DE602004024038D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44786003P 2003-02-13 2003-02-13
PCT/US2004/004286 WO2004077014A2 (en) 2003-02-13 2004-02-13 Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores

Publications (1)

Publication Number Publication Date
DE602004024038D1 true DE602004024038D1 (de) 2009-12-24

Family

ID=32927466

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004024038T Expired - Lifetime DE602004024038D1 (de) 2003-02-13 2004-02-13 Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren

Country Status (11)

Country Link
US (1) US8993335B2 (de)
EP (3) EP2351856A1 (de)
JP (1) JP4740111B2 (de)
CN (1) CN1771335A (de)
AT (1) ATE448327T1 (de)
AU (1) AU2004215006A1 (de)
CA (1) CA2515155C (de)
DE (1) DE602004024038D1 (de)
DK (1) DK1599609T3 (de)
ES (1) ES2440920T3 (de)
WO (1) WO2004077014A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
US9371559B2 (en) 2002-06-20 2016-06-21 The Regents Of The University Of California Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US10001475B2 (en) 2002-06-20 2018-06-19 The Regents Of The University Of California Light harvesting multichromophore compositions and methods of using the same
US7144950B2 (en) 2003-09-17 2006-12-05 The Regents Of The University Of California Conformationally flexible cationic conjugated polymers
CN1694967B (zh) 2002-08-26 2010-12-15 加州大学评议会 利用集光多发色团的多核苷酸的检测和分析的方法以及组合物
JP4740111B2 (ja) 2003-02-13 2011-08-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 集光性多発色団を用いてポリヌクレオチド結合タンパク質相互作用を検出及び分析するための方法並びに組成物
US8628690B2 (en) * 2004-02-23 2014-01-14 The Texas A&M University System Nanoemulsion compositions and methods of use thereof
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
WO2006074482A2 (en) * 2005-01-10 2006-07-13 The Regents Of The University Of California Methods and kits for strand-specific polynucleotide detection with cationic multichromophores
WO2006074471A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006083932A2 (en) * 2005-01-31 2006-08-10 The Regents Of The University Methods and compositions for aggregant detection
CA2598096C (en) * 2005-03-03 2014-02-11 National Research Council Of Canada Methods and compositions for the detection and analysis of nucleic acids by signal amplification
JP5420414B2 (ja) 2006-10-06 2014-02-19 シリゲン グループ リミテッド 指向性バイオマーカシグナル増幅用の蛍光方法および材料
WO2009009889A1 (en) * 2007-07-13 2009-01-22 National Research Council Of Canada Ultrasensitive detection of target using target-ready particles
WO2010151807A1 (en) 2009-06-26 2010-12-29 Sirigen, Inc. Signal amplified biological detection with conjugated polymers
US8575303B2 (en) 2010-01-19 2013-11-05 Sirigen Group Limited Reagents for directed biomarker signal amplification
US8611828B2 (en) * 2010-06-30 2013-12-17 Wolfgang Richter System and methods for self-powered, contactless, self-communicating sensor devices
CN102384978A (zh) * 2011-08-30 2012-03-21 南京邮电大学 一种检测脱氧核糖核酸结合蛋白的荧光检测方法
KR101441594B1 (ko) * 2012-12-27 2014-09-23 매쓰파워 주식회사 온도 민감 폴리머 합성체를 이용한 핵산 증폭 디스크 장치 및 이를 이용한 분석 방법
WO2015050869A1 (en) 2013-10-02 2015-04-09 Becton Dickinson And Company Polymersome encapsulation of hydrophobic fluorescent polymers
CN104292185B (zh) * 2014-09-03 2016-06-22 武汉工程大学 一种胺基n-氧化水/醇溶性寡聚物及其合成方法和应用
WO2016191004A1 (en) 2015-05-26 2016-12-01 Becton, Dickinson And Company Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light
US10472521B2 (en) 2015-12-16 2019-11-12 Becton, Dickinson And Company Photostable fluorescent polymeric tandem dyes including luminescent metal complexes
JP2019512573A (ja) 2016-03-28 2019-05-16 エーエーティー バイオクエスト インコーポレイテッド ポリフルオレノ[4,5−cde]オキセピンコンジュゲート及び分析物検出方法におけるそれらの使用
US10545137B2 (en) 2016-04-22 2020-01-28 Becton, Dickinson And Company Multiplex polymeric dye devices and methods for using the same
EP3481901A4 (de) 2016-07-07 2020-07-15 Becton, Dickinson and Company Fluoreszierende wassersolvatierte konjugierte polymere
US10920082B2 (en) 2016-07-11 2021-02-16 Becton, Dickinson And Company Blue-excitable water-solvated polymeric dyes
CN106770088B (zh) * 2016-11-24 2019-06-11 北京科技大学 用于dna检测的荧光复合纳米粒子的制备及检测方法
AU2017375751B2 (en) 2016-12-12 2021-05-20 Becton, Dickinson And Company Water-soluble polymeric dyes
WO2018148098A2 (en) 2017-02-08 2018-08-16 Becton, Dickinson And Company Dried dye reagent devices and methods for making and using the same
CN106857504B (zh) * 2017-02-10 2020-03-10 中国科学院化学研究所 一种抑制和/或破坏生物膜的方法
KR20230147735A (ko) 2017-06-16 2023-10-23 듀크 유니버시티 개선된 라벨 검출, 계산, 분석물 감지, 및 조정 가능한 난수 생성을 위한 공진기 네트워크
EP3438649B1 (de) * 2017-07-31 2020-03-11 Vestel Elektronik Sanayi ve Ticaret A.S. Identifizierungs-tag und verfahren zum identifizieren eines objekts
CN107417772B (zh) * 2017-09-07 2020-03-27 华中科技大学同济医学院附属协和医院 一种可拮抗hnRNPU蛋白RNA结合活性的多肽HIP-20及其应用
EP3732254A4 (de) 2017-12-26 2021-12-22 Becton, Dickinson and Company Tiefe uv-erregbare wassersolvatisierte polymerfarbstoffe
EP3833716A4 (de) * 2018-08-07 2022-04-27 Becton, Dickinson and Company Polymertandemfarbstoffe mit einem anhängenden schmalen emissionsakzeptor
CN117180836A (zh) 2018-11-13 2023-12-08 贝克顿·迪金森公司 干燥试剂滤网及其制造和使用方法
US20220306683A1 (en) * 2019-06-07 2022-09-29 The Trustees Of Princeton University Proximity-based labeling systems and applications thereof

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4950587A (en) 1988-09-02 1990-08-21 Eastman Kodak Company J-aggregating dye polymers as spectral sensitizers for silver halide photographic compositions
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US4948843A (en) 1989-05-30 1990-08-14 Eastman Kodak Company Dye polymer/sol-gel composites
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5763162A (en) 1990-03-14 1998-06-09 The Regents Of University Of California Multichromophore fluorescent DNA intercalation complexes
EP0562025B1 (de) 1990-12-06 2001-02-07 Affymetrix, Inc. (a Delaware Corporation) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5408109A (en) 1991-02-27 1995-04-18 The Regents Of The University Of California Visible light emitting diodes fabricated from soluble semiconducting polymers
ATE262374T1 (de) 1991-11-22 2004-04-15 Affymetrix Inc Kombinatorische strategien für polymersynthese
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5536820A (en) 1993-02-26 1996-07-16 E. I. Du Pont De Nemours And Company Avidin-binding azo reagents
EP0708837B1 (de) 1993-07-13 2006-03-08 Abbott Laboratories Durch fluoreszierenden polymer markierte konjugate und zwischen produkte
DE69532255D1 (de) 1994-05-26 2004-01-22 Canon Kk Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
AU7221398A (en) 1997-04-29 1998-11-24 Nycomed Imaging As Method of demarcating tissue
US5881083A (en) 1997-07-03 1999-03-09 The Regents Of The University Of California Conjugated polymers as materials for solid state laser
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
KR100575407B1 (ko) 1998-01-09 2006-05-03 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 효소 특이적 절단성 폴리뉴클레오티드 기질 및 이의 분석방법
CA2318779C (en) * 1998-01-22 2009-08-25 Luminex Corporation Microparticles with multiple fluorescent signals
US5968762A (en) 1998-03-19 1999-10-19 The University Of Connecticut Method for detecting bacteria in a sample
JP2000019171A (ja) * 1998-04-28 2000-01-21 Kazuko Matsumoto 標識プローブによる分析方法
DE69915466T2 (de) 1998-05-05 2005-01-20 Massachusetts Institute Of Technology, Cambridge Lichtemittierende polymere und vorrichtungen, die diese enthalten
EP1281744B1 (de) 1998-05-05 2008-09-24 Massachusetts Institute Of Technology Emittierende Polymere und Vorrichtungen diese Polymere enthaltend
US6263286B1 (en) 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
GB9819417D0 (en) 1998-09-07 1998-10-28 Secr Defence Reaction method
EP2306195A3 (de) 1998-09-18 2012-04-25 Massachusetts Institute of Technology Biologische Anwendungen von Halbleiternanokristallen
US6951682B1 (en) 1998-12-01 2005-10-04 Syntrix Biochip, Inc. Porous coatings bearing ligand arrays and use thereof
IL141383A (en) 1999-05-05 2005-11-20 Univ California Sensor containing a polymer for detecting biological agents and methods utilizing the same
US6541671B1 (en) 2002-02-13 2003-04-01 The Regents Of The University Of California Synthesis of 2H- and 13C-substituted dithanes
EP1234182A2 (de) 1999-06-30 2002-08-28 Iris Bio Technologies Hybridisierung von ziel-dna mit immobilisierten nukleinsäureanaloga
CA2381568A1 (en) 1999-07-30 2001-02-08 The Penn State Research Foundation Instruments, methods and reagents for surface plasmon resonance
US20020009728A1 (en) 2000-01-18 2002-01-24 Quantum Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US6984528B2 (en) 2000-03-20 2006-01-10 Analytical Biological Services Inc. Method for detecting an analyte by fluorescence
US6653080B2 (en) 2000-03-22 2003-11-25 Quantum Dot Corporation Loop probe hybridization assay for polynucleotide analysis
IL152711A0 (en) 2000-05-08 2003-06-24 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
WO2001095059A2 (en) 2000-06-06 2001-12-13 Dna Sciences, Inc. A method and system for populating a database
US20020177136A1 (en) 2000-08-23 2002-11-28 Mcbranch Duncan W. Peptide nucleic acid based molecular sensors for nucleic acids
WO2002068932A2 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
EP1373577A4 (de) 2001-03-16 2005-03-09 Qtl Biosystems Llc Bioassays auf grundlage des fluoreszenzpolymer-superquenching
AU2002252868C1 (en) 2001-04-05 2008-04-17 Infectio Diagnostic (I.D.I.), Inc. Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
WO2002084271A2 (en) 2001-04-16 2002-10-24 The Regents Of The University Of California Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides
IL160519A0 (en) 2001-08-23 2004-07-25 Qtl Biosystems Llc Bio-sensing platforms for detection and quantitation of biological molecules
DE10153829A1 (de) 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
AU2002363530A1 (en) 2001-11-07 2003-05-19 Sensor Technologies Llc Method of identifying energy transfer sensors for analytes
US20040023248A1 (en) 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
US6808542B2 (en) 2001-12-26 2004-10-26 American Dye Source, Inc. Photoluminescent markers and methods for detection of such markers
AU2003253590A1 (en) 2002-03-29 2003-11-10 Board Of Regents For The Oklahoma Agricultural And Mechanical Colleges, Acting For And On Behalf Of Oklahoma State University Implantable biosensor from stratified nanostructured membranes
CA2480673A1 (en) 2002-03-29 2003-10-09 Genentech, Inc. Methods and compositions for detection and quantitation of nucleic acid analytes
US20070059690A1 (en) 2002-05-31 2007-03-15 Amirul Islam "Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands"
EP2278027A3 (de) 2002-06-20 2011-02-16 The Regents of the University of California Verfahren und Zusammensetzungen zum Nachweis und zur Analyse von Polynukleotiden unter Verwendung von licht einfangenden Multichromophoren
CN1694967B (zh) 2002-08-26 2010-12-15 加州大学评议会 利用集光多发色团的多核苷酸的检测和分析的方法以及组合物
SG111090A1 (en) 2002-10-25 2005-05-30 Agency Science Tech & Res Cationic water-soluble conjugated polymers and their precursors
MXPA05006384A (es) * 2002-12-17 2005-08-29 Merck Patent Gmbh Anticuerpo humanizado (h14.18) del anticuerpo 14.18 de raton enlazado a gd2 y su fusion con il-2.
US20040121337A1 (en) 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
JP4740111B2 (ja) 2003-02-13 2011-08-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 集光性多発色団を用いてポリヌクレオチド結合タンパク質相互作用を検出及び分析するための方法並びに組成物
JP3912393B2 (ja) 2003-08-08 2007-05-09 セイコーエプソン株式会社 有機エレクトロルミネッセンス装置の製造方法
WO2005056628A2 (en) 2003-09-17 2005-06-23 The Regents Of The University Of California Methods and devices comprising soluble conjugated polymers
US7141437B2 (en) 2003-11-13 2006-11-28 Michigan Molecular Institute Solid-state colorimetric biosensors comprised of dendritic polymer networks
WO2005073338A2 (en) 2003-12-04 2005-08-11 Massachusetts Institute Of Technology Fluorescent, semi-conductive polymers, and devices comprising them
US7759127B2 (en) 2003-12-05 2010-07-20 Massachusetts Institute Of Technology Organic materials able to detect analytes
CA2544476A1 (en) 2003-12-12 2005-06-23 Infectio Recherche Inc. System for charge-based detection of nucleic acids
SE0401219D0 (sv) 2004-05-10 2004-05-10 Biochromix Ab Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
US7368086B2 (en) 2004-10-29 2008-05-06 Invitrogen Corporation Functionalized fluorescent nanocrystals, and methods for their preparation and use
WO2006074471A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
WO2006074482A2 (en) 2005-01-10 2006-07-13 The Regents Of The University Of California Methods and kits for strand-specific polynucleotide detection with cationic multichromophores
CA2598096C (en) 2005-03-03 2014-02-11 National Research Council Of Canada Methods and compositions for the detection and analysis of nucleic acids by signal amplification
JP2016031772A (ja) 2014-07-30 2016-03-07 株式会社日立ハイテクファインシステムズ 熱アシスト磁気ヘッド素子の検査方法及びその装置

Also Published As

Publication number Publication date
EP1599609A4 (de) 2007-10-31
CN1771335A (zh) 2006-05-10
EP2351856A1 (de) 2011-08-03
ES2440920T3 (es) 2014-01-31
JP2006517801A (ja) 2006-08-03
DK1599609T3 (da) 2010-03-29
ATE448327T1 (de) 2009-11-15
EP1599609A2 (de) 2005-11-30
CA2515155A1 (en) 2004-09-10
AU2004215006A1 (en) 2004-09-10
WO2004077014A3 (en) 2005-07-14
US8993335B2 (en) 2015-03-31
EP2161343B1 (de) 2013-10-23
EP1599609B1 (de) 2009-11-11
CA2515155C (en) 2013-11-19
WO2004077014A2 (en) 2004-09-10
EP2161343A1 (de) 2010-03-10
JP4740111B2 (ja) 2011-08-03
US20050003386A1 (en) 2005-01-06

Similar Documents

Publication Publication Date Title
DE602004024038D1 (de) Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotidbindungsproteinwechselwirkungen unter verwendung licht sammelnder multichromophoren
DE60333646D1 (de) Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren
WO2004092324A3 (en) Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
ATE428929T1 (de) Reagens, ausstattung und verfahren zur probenanalyse
DE60133111D1 (de) Verfahren zur erkennung und zum assay von nukleinsäuresequenzen
WO2005017184A3 (en) Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates
DE60040603D1 (de) Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
DE602004030114D1 (de) System zum nachweis von polynukleotiden
DE60334029D1 (de) Hochempfindliche assays für die pathogendetektion unterverwendung der metallverstärkten fluoreszenz
ATE398187T1 (de) Verfahren zum nachweis von ziel-nukleinsäuren mittels pcr
ATE438740T1 (de) Verfahren und nukleinsäuren zur analyse von mit der prognose von störungen der proliferation von prostatazellen assoziierter genexpression
ATE488588T1 (de) Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker
DE60216777D1 (de) Multiplex-hpv-pcr-fluoreszenzassays unter verwendung mehrerer fluorophore
ATE533052T1 (de) Reagenzien, kits und verfahren zum nachweis biologischer moleküle mittels energieübertragung von einem aktivierten chemilumineszenzsubstrat auf einen energieakzeptorfarbstoff
ATE522812T1 (de) Verfahren und zusammensetzung zum bestimmen von homocystein
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
ATE553216T1 (de) Sonden, bibliotheken und kits zur analyse von nukleinsäuregemischen und verfahren zu deren konstruktion
ATE452990T1 (de) Verfahren zur zählung und identifikation von mikroorganismen
ATE371857T1 (de) Verfahren zur identifikation von fluoreszierenden,lumineszierenden und/oder absorbierenden substanzen auf und/oder in probenträgern
ATE449185T1 (de) Nukleinsäuren zur identifizierung von pilzen und verfahren zu deren verwendung
ATE372392T1 (de) Verfahren zur bestimmung der menge einer zielnukleinsäure in einer probe
WO2001068913A3 (en) Nucleic acid detection method and system
CN219608936U (zh) 一种基于raa等温扩增试剂的猫瘟病毒核酸胶体金试纸条
WO2002084271A3 (en) Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides
ATE493516T1 (de) Verfahren und vorrichtung zur authentifizierung von mit einer markierung versehenen gegenständen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition