DE602004021509D1 - Spezifischer Marker Lmx1a für dopaminerge Neuronen - Google Patents

Spezifischer Marker Lmx1a für dopaminerge Neuronen

Info

Publication number
DE602004021509D1
DE602004021509D1 DE602004021509T DE602004021509T DE602004021509D1 DE 602004021509 D1 DE602004021509 D1 DE 602004021509D1 DE 602004021509 T DE602004021509 T DE 602004021509T DE 602004021509 T DE602004021509 T DE 602004021509T DE 602004021509 D1 DE602004021509 D1 DE 602004021509D1
Authority
DE
Germany
Prior art keywords
lmx1a
cells
dopaminergic neurons
specific marker
cell cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004021509T
Other languages
English (en)
Inventor
Yuichi Ono
Yasuko Nakagawa
Tomoya Nakatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of DE602004021509D1 publication Critical patent/DE602004021509D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9413—Dopamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
DE602004021509T 2003-11-26 2004-11-26 Spezifischer Marker Lmx1a für dopaminerge Neuronen Active DE602004021509D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003395493 2003-11-26
PCT/JP2004/017574 WO2005052190A1 (ja) 2003-11-26 2004-11-26 ドーパミン産生ニューロン特異的マーカーLmx1a

Publications (1)

Publication Number Publication Date
DE602004021509D1 true DE602004021509D1 (de) 2009-07-23

Family

ID=34631489

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004021509T Active DE602004021509D1 (de) 2003-11-26 2004-11-26 Spezifischer Marker Lmx1a für dopaminerge Neuronen

Country Status (7)

Country Link
US (2) US8187804B2 (de)
EP (1) EP1712638B1 (de)
JP (1) JP4236270B2 (de)
CN (1) CN1906309B (de)
AT (1) ATE433501T1 (de)
DE (1) DE602004021509D1 (de)
WO (1) WO2005052190A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG146441A1 (en) 2002-10-22 2008-10-30 Eisai R&D Man Co Ltd Gene specifically expressed in postmitotic dopaminergic neuron precursor cells
WO2004065599A1 (ja) * 2003-01-24 2004-08-05 Eisai Co., Ltd. Lrp4/Corinドーパミン産生ニューロン増殖前駆細胞マーカー
AU2005264579B2 (en) 2004-07-22 2010-06-10 Eisai R&D Management Co., Ltd. Lrp4/Corin dopaminergic neuron progenitor cell markers
EP1838841A2 (de) * 2004-12-23 2007-10-03 The Ludwig Institute for Cancer Research Technisch hergestellte dopaminneuronen und deren verwendungen
JP4926965B2 (ja) 2005-08-18 2012-05-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ドーパミン産生ニューロン増殖前駆細胞マーカーＮａｔｏ３
JP4926966B2 (ja) * 2005-08-18 2012-05-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ドーパミン産生ニューロン増殖前駆細胞マーカーＭｓｘ１／２
CN101466836A (zh) 2006-04-11 2009-06-24 卫材R&D管理有限公司 多巴胺能神经元祖细胞标志物187a5
WO2011144901A1 (en) 2010-05-20 2011-11-24 The University Of Newcastle Upon Tyne Expansion and directed differentiation of epidermal neural crest stem cells
CN105941328B (zh) * 2010-11-05 2019-04-09 斯坦福大学托管董事会 一种鉴定抑制前额叶皮质中的兴奋性或抑制性神经元的去极化的化合物的***
EP2737057B1 (de) * 2011-07-27 2018-10-24 Kyoto University Neue marker für dopaminerge neuronale vorläuferzellen
CN103275935B (zh) * 2012-12-12 2015-09-23 中国医学科学院医学生物学研究所 SHH/Lmx1a信号通路调控NTN修饰的rASCs分化多巴胺能神经元的方法
WO2015034012A1 (ja) 2013-09-05 2015-03-12 国立大学法人京都大学 新規ドーパミン産生神経前駆細胞の誘導方法
EP3447130A4 (de) 2016-04-22 2019-11-13 Kyoto University Verfahren zur herstellung von dopaminproduzierenden neuralen vorläuferzellen
JP2019106895A (ja) * 2017-12-15 2019-07-04 インダストリー‐ユニバーシティー コーぺレーション ファンデーション ハンヤン ユニバーシティ 神経幹細胞または神経前駆細胞からドーパミン神経細胞への分化方法
WO2022222974A1 (zh) * 2021-04-21 2022-10-27 上海跃赛生物科技有限公司 一种质控和富集人多巴胺能神经前体细胞的方法
CN114716508B (zh) * 2022-04-12 2023-10-10 中山大学 靶向dat蛋白的多肽及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270998B2 (en) * 2000-06-01 2007-09-18 Japan Science And Technology Corporation Method of concentrating and separating dopaminergic neurons
WO2002063938A2 (en) * 2000-12-05 2002-08-22 Layton Bioscience Inc. Production and use of dopaminergic cells to treat dopaminergic deficiencies
WO2003010329A2 (en) * 2001-07-26 2003-02-06 Incyte Genomics, Inc. Nucleic acid-associated proteins
SG146441A1 (en) 2002-10-22 2008-10-30 Eisai R&D Man Co Ltd Gene specifically expressed in postmitotic dopaminergic neuron precursor cells
US20060292669A1 (en) * 2002-11-28 2006-12-28 Eisai Co., Ltd. Mammalian prickle gene
WO2004065599A1 (ja) 2003-01-24 2004-08-05 Eisai Co., Ltd. Lrp4/Corinドーパミン産生ニューロン増殖前駆細胞マーカー
EP1838841A2 (de) * 2004-12-23 2007-10-03 The Ludwig Institute for Cancer Research Technisch hergestellte dopaminneuronen und deren verwendungen

Also Published As

Publication number Publication date
US20120178083A1 (en) 2012-07-12
CN1906309B (zh) 2011-12-14
EP1712638A1 (de) 2006-10-18
US8580523B2 (en) 2013-11-12
CN1906309A (zh) 2007-01-31
US20070254281A1 (en) 2007-11-01
JPWO2005052190A1 (ja) 2007-12-06
EP1712638B1 (de) 2009-06-10
US8187804B2 (en) 2012-05-29
ATE433501T1 (de) 2009-06-15
WO2005052190A1 (ja) 2005-06-09
EP1712638A4 (de) 2007-10-03
JP4236270B2 (ja) 2009-03-11

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