DE602004018162D1 - hERG1-CHANNEL OPENER FOR THE TREATMENT OF HERZARRYTHMIES - Google Patents

hERG1-CHANNEL OPENER FOR THE TREATMENT OF HERZARRYTHMIES

Info

Publication number
DE602004018162D1
DE602004018162D1 DE602004018162T DE602004018162T DE602004018162D1 DE 602004018162 D1 DE602004018162 D1 DE 602004018162D1 DE 602004018162 T DE602004018162 T DE 602004018162T DE 602004018162 T DE602004018162 T DE 602004018162T DE 602004018162 D1 DE602004018162 D1 DE 602004018162D1
Authority
DE
Germany
Prior art keywords
treatment
herzarrythmies
herg1
channel opener
channel openers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004018162T
Other languages
German (de)
Inventor
Soeren Peter Olesen
Morten Grunnet
Palle Christophersen
Dorte Strobaek
Joachim Demnitz
Rie S Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE602004018162D1 publication Critical patent/DE602004018162D1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Surgical Instruments (AREA)
  • Processing Of Meat And Fish (AREA)
  • Finger-Pressure Massage (AREA)

Abstract

This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.
DE602004018162T 2003-09-04 2004-09-06 hERG1-CHANNEL OPENER FOR THE TREATMENT OF HERZARRYTHMIES Active DE602004018162D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301264 2003-09-04
PCT/EP2004/052046 WO2005023237A1 (en) 2003-09-04 2004-09-06 Erg channel openers for the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
DE602004018162D1 true DE602004018162D1 (en) 2009-01-15

Family

ID=34259076

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004018162T Active DE602004018162D1 (en) 2003-09-04 2004-09-06 hERG1-CHANNEL OPENER FOR THE TREATMENT OF HERZARRYTHMIES

Country Status (10)

Country Link
US (2) US7851492B2 (en)
EP (1) EP1663192B1 (en)
JP (2) JP2007504202A (en)
CN (1) CN1845726A (en)
AT (1) ATE415959T1 (en)
AU (1) AU2004269924A1 (en)
CA (1) CA2537746A1 (en)
DE (1) DE602004018162D1 (en)
MX (1) MXPA06002315A (en)
WO (1) WO2005023237A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287456A (en) * 2004-12-17 2008-10-15 神经研究公司 Diphenylurea derivatives useful as potassium channel activators
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
CA2630639A1 (en) * 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
EP1996190A1 (en) * 2006-03-14 2008-12-03 Neurosearch A/S Diphenylurea derivatives and their use as chloride channel blockers or bkca channel modulators
EP2212303A1 (en) * 2007-11-26 2010-08-04 NeuroSearch AS Novel benzamide derivatives useful as potassium channel modulators
US20130017198A1 (en) * 2010-03-25 2013-01-17 The Uab Research Foundation Manipulation of calcium channels to regulate after-depolarization events in cardiac myocytes
KR20160142887A (en) * 2014-04-17 2016-12-13 노파르티스 아게 Polycyclic herg activators
CN105343120A (en) * 2015-11-19 2016-02-24 宁波市医疗中心李惠利医院 Applications of AMO-103 in preparing medicines used for treating arrhythmia
JP7111359B2 (en) * 2018-02-08 2022-08-02 国立大学法人東北大学 Plant Potassium Ion Transporter Function Controlling Agent and Plant Growing Method
JP7336133B2 (en) * 2019-08-07 2023-08-31 国立大学法人東北大学 Diphenylurea compound derivative

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
CN1060467A (en) * 1990-09-25 1992-04-22 武田药品工业株式会社 1,3-benzoxazine derivatives, its production method and purposes
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
DK41193D0 (en) * 1993-04-07 1993-04-07 Neurosearch As ion channel openers
US5416097A (en) * 1993-05-19 1995-05-16 Berlex Laboratories, Inc. Potassium channel activators/openers
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
JPH11503110A (en) 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist
ATE316133T1 (en) 1995-03-09 2006-02-15 Univ Utah Res Found ßLONG QTß GENES AND METHOD FOR DIAGNOSING OR PREVENTING ßLONG QTß SYNDROME
AU2962297A (en) 1996-05-24 1998-01-05 Neurosearch A/S Phenyl derivatives useful as blockers of chloride channels
DE69716424T2 (en) 1996-05-24 2003-02-20 Neurosearch A/S, Ballerup PHENYL DERIVATIVES CONTAINING ACID GROUPS, THEIR PRODUCTION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
BR9808938A (en) * 1997-04-22 2000-08-01 Neurosearch As Compound, pharmaceutical composition, use of a compound, processes for treating a disorder or disease of a living animal body and for the preparation of a compound, and use of chloride channel blockers
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
CA2316853A1 (en) * 1998-01-14 1999-07-22 Ayatsugu Nakamura Potassium channel activators
US6207383B1 (en) 1998-07-27 2001-03-27 University Of Utah Research Foundation Mutations in and genomic structure of HERG—a long QT syndrome gene
AP2001002103A0 (en) 1998-10-22 2001-03-31 Neurosearch As Substituted phenyl derivatives, their preparation and use.
WO2002042735A2 (en) * 2000-10-30 2002-05-30 Vanderbuilt University Human kcr1 regulation of herg potassium channel block
CA2428979A1 (en) 2000-11-20 2002-05-30 Merck & Co., Inc. Human erg2 potassium channel
EP1361874A1 (en) 2001-02-15 2003-11-19 Neurosearch A/S Treatment of diseases characterized by excessive or insufficient cell death
WO2003000245A1 (en) 2001-06-22 2003-01-03 Poseidon Pharmaceuticals A/S Compounds for use in disorders associated with mast cell or basophil activity
CN100497302C (en) * 2002-09-05 2009-06-10 神经研究公司 Diarylurea derivatives and their use as chloride channel blockers
WO2005023238A1 (en) * 2003-09-04 2005-03-17 Poseidon Pharmaceuticals A/S Erg channel openers for the treatment of hyperexcitability-related neuronal diseases
CA2630639A1 (en) 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
US20090047703A1 (en) * 2007-08-17 2009-02-19 University Of Maryland, Baltimore ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease

Also Published As

Publication number Publication date
WO2005023237A1 (en) 2005-03-17
JP2007504202A (en) 2007-03-01
MXPA06002315A (en) 2006-05-22
EP1663192B1 (en) 2008-12-03
AU2004269924A1 (en) 2005-03-17
EP1663192A1 (en) 2006-06-07
US7851492B2 (en) 2010-12-14
US20060281794A1 (en) 2006-12-14
CN1845726A (en) 2006-10-11
CA2537746A1 (en) 2005-03-17
ATE415959T1 (en) 2008-12-15
US20110071164A1 (en) 2011-03-24
JP2011052004A (en) 2011-03-17

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