DE602004002964D1 - 7-azaindolderivate als cox2-inhibitoren - Google Patents

7-azaindolderivate als cox2-inhibitoren

Info

Publication number
DE602004002964D1
DE602004002964D1 DE602004002964T DE602004002964T DE602004002964D1 DE 602004002964 D1 DE602004002964 D1 DE 602004002964D1 DE 602004002964 T DE602004002964 T DE 602004002964T DE 602004002964 T DE602004002964 T DE 602004002964T DE 602004002964 D1 DE602004002964 D1 DE 602004002964D1
Authority
DE
Germany
Prior art keywords
cox2 inhibitors
azaindol
derivatives
azaindol derivatives
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004002964T
Other languages
English (en)
Other versions
DE602004002964T2 (de
Inventor
Paul Beswick
Robert Gleave
Martin Swarbrick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE602004002964D1 publication Critical patent/DE602004002964D1/de
Application granted granted Critical
Publication of DE602004002964T2 publication Critical patent/DE602004002964T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602004002964T 2003-08-13 2004-08-11 7-azaindolderivate als cox2-inhibitoren Expired - Fee Related DE602004002964T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0319037 2003-08-13
GBGB0319037.8A GB0319037D0 (en) 2003-08-13 2003-08-13 7-Azaindole Derivatives
PCT/EP2004/009073 WO2005016924A1 (en) 2003-08-13 2004-08-11 7-azaindole derivatives as cox2 inhibitors

Publications (2)

Publication Number Publication Date
DE602004002964D1 true DE602004002964D1 (de) 2006-12-07
DE602004002964T2 DE602004002964T2 (de) 2007-05-10

Family

ID=28052458

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004002964T Expired - Fee Related DE602004002964T2 (de) 2003-08-13 2004-08-11 7-azaindolderivate als cox2-inhibitoren

Country Status (8)

Country Link
US (1) US20060270880A1 (de)
EP (1) EP1654262B1 (de)
JP (1) JP2007501834A (de)
AT (1) ATE343576T1 (de)
DE (1) DE602004002964T2 (de)
ES (1) ES2274483T3 (de)
GB (1) GB0319037D0 (de)
WO (1) WO2005016924A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003258630A1 (en) 2002-08-19 2004-03-11 Glaxo Group Limited Pyrimidine derivatives as selective cox-2 inhibitors
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
EP1742627A4 (de) 2004-05-06 2009-08-26 Plexxikon Inc Pde4b-hemmer und ihre verwendung
WO2006026754A2 (en) * 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
US7727142B2 (en) * 2006-03-03 2010-06-01 Acorn Cardiovascular, Inc. Delivery tool for cardiac support device
MX2009010890A (es) 2007-04-18 2009-10-26 Astrazeneca Ab Nuevo proceso para la fabricacion del compuesto de 2-hidroxi-3-[5-(morfolin-4-ilmetil)piridin-2-il]1h-indol-5-carbon itrilo 701.
WO2020168068A1 (en) * 2019-02-13 2020-08-20 The University Of Vermont And State Agricultural College Small molecule antagonist to pacap receptor and uses thereof
EP4027993A4 (de) * 2019-09-13 2023-09-20 The Broad Institute Inc. Cyclooxygenase-inhibitoren und verwendungen davon

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149109A (en) * 1962-02-20 1964-09-15 Searle & Co Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines
GB1121922A (en) * 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives
US5474955A (en) * 1993-08-06 1995-12-12 Micron Technology, Inc. Method for optimizing thermal budgets in fabricating semconductors
CA2276945C (en) * 1993-11-30 2006-08-01 G.D. Searle & Co. Tricyclic-substituted pyrazolyl benzenesulfonamides and pharmaceutical compositions thereof
US6020343A (en) * 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
AP9801302A0 (en) * 1997-07-23 2000-01-23 Pfizer Indole compounds as anti-inflammatory/analgesic agents..
EP1510519B1 (de) * 1997-09-05 2006-02-15 Glaxo Group Limited Pharmazeutische Zusammensetzung, enthaltend 2,3-Diaryl-Pyrazolo[1,5-b]Pyridazin Derivate
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6306866B1 (en) * 1998-03-06 2001-10-23 American Cyanamid Company Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
ATE482945T1 (de) * 1998-05-26 2010-10-15 Chugai Pharmaceutical Co Ltd Heterozyklische indolderivate und mono- oder diazaindol-derivate
US6313072B1 (en) * 1999-02-18 2001-11-06 American Cyanamid Company Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
WO2000052008A1 (en) * 1999-02-27 2000-09-08 Glaxo Group Limited Pyrazolopyridines
GB9927844D0 (en) * 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
GB9930358D0 (en) * 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0003224D0 (en) * 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
US6756498B2 (en) * 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
US6861249B1 (en) * 2002-04-09 2005-03-01 David Kent Microbial spray for animal waste

Also Published As

Publication number Publication date
GB0319037D0 (en) 2003-09-17
WO2005016924A1 (en) 2005-02-24
EP1654262A1 (de) 2006-05-10
DE602004002964T2 (de) 2007-05-10
ATE343576T1 (de) 2006-11-15
US20060270880A1 (en) 2006-11-30
EP1654262B1 (de) 2006-10-25
JP2007501834A (ja) 2007-02-01
ES2274483T3 (es) 2007-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee