DE60141297D1 - Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörper - Google Patents
Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörperInfo
- Publication number
- DE60141297D1 DE60141297D1 DE60141297T DE60141297T DE60141297D1 DE 60141297 D1 DE60141297 D1 DE 60141297D1 DE 60141297 T DE60141297 T DE 60141297T DE 60141297 T DE60141297 T DE 60141297T DE 60141297 D1 DE60141297 D1 DE 60141297D1
- Authority
- DE
- Germany
- Prior art keywords
- monoclonal antibody
- tuned
- human bst2
- bst2 antigen
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000740785 Homo sapiens Bone marrow stromal antigen 2 Proteins 0.000 title abstract 2
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000047829 human BST2 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000403245 | 2000-12-28 | ||
PCT/JP2001/011493 WO2002057316A1 (fr) | 2000-12-28 | 2001-12-26 | Nouvel anticorps monoclonal |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60141297D1 true DE60141297D1 (de) | 2010-03-25 |
Family
ID=18867405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60141297T Expired - Lifetime DE60141297D1 (de) | 2000-12-28 | 2001-12-26 | Gegen das menschliche bst2 antigen gerichteter monoklonaler antikörper |
Country Status (6)
Country | Link |
---|---|
US (1) | US7592005B2 (de) |
EP (1) | EP1354896B1 (de) |
JP (1) | JP4450555B2 (de) |
AT (1) | ATE457318T1 (de) |
DE (1) | DE60141297D1 (de) |
WO (1) | WO2002057316A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
NO347360B1 (no) * | 2003-10-10 | 2023-09-25 | Immunogen Inc | Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. |
US8435530B2 (en) * | 2004-06-11 | 2013-05-07 | Sbi Biotech Co., Ltd. | Methods for suppressing activity of activated interferon-producing cells |
US20100143899A1 (en) * | 2005-05-17 | 2010-06-10 | University Of Vermont And State Agricultural College | Methods and products for diagnosing cancer |
AU2007299843B2 (en) | 2006-09-18 | 2012-03-08 | Xencor, Inc | Optimized antibodies that target HM1.24 |
US8445442B2 (en) * | 2007-04-26 | 2013-05-21 | University Of Vermont And State Agricultural College | CCL18 and CCL3 methods and compositions for detecting and treating cancer |
AU2008312858A1 (en) * | 2007-10-16 | 2009-04-23 | Sbi Biotech Co., Ltd. | Anti-BST2 antibody |
CA3146422A1 (en) | 2008-03-18 | 2009-09-24 | Genentech, Inc. | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
AU2009248735B2 (en) * | 2008-05-23 | 2015-08-20 | Fit Biotech Oy | Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant |
ES2602971T3 (es) | 2010-03-02 | 2017-02-23 | Kyowa Hakko Kirin Co., Ltd. | Composición de anticuerpo modificado |
AU2011318574B2 (en) * | 2010-10-20 | 2016-03-03 | Oxford Biotherapeutics Ltd. | Antibodies |
CN107619443B (zh) * | 2016-07-14 | 2020-08-14 | 深圳宾德生物技术有限公司 | 抗人和鼠cd317的单克隆抗体及其制备方法和应用 |
US20210330801A1 (en) | 2017-03-02 | 2021-10-28 | Cadila Healthcare Limited | Novel protein drug conjugate formulation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA76934C2 (en) * | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
BR9811094A (pt) * | 1997-02-12 | 2000-07-18 | Chugai Pharmaceutical Co Ltd | Agente terapêutico para tumores linfáticos |
CA2282631A1 (en) | 1997-02-28 | 1998-09-03 | Chugai Seiyaku Kabushiki Kaisha | Lymphocyte activation inhibitors |
US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
JPH1192399A (ja) * | 1997-09-24 | 1999-04-06 | Chugai Pharmaceut Co Ltd | 骨髄腫治療剤 |
WO1999043703A1 (fr) | 1998-02-25 | 1999-09-02 | Chugai Seiyaku Kabushiki Kaisha | Technique de dosage immunochimique de l'anticorps anti-hm1.24 |
-
2001
- 2001-12-26 DE DE60141297T patent/DE60141297D1/de not_active Expired - Lifetime
- 2001-12-26 WO PCT/JP2001/011493 patent/WO2002057316A1/ja active Application Filing
- 2001-12-26 US US10/451,947 patent/US7592005B2/en not_active Expired - Fee Related
- 2001-12-26 EP EP01273341A patent/EP1354896B1/de not_active Expired - Lifetime
- 2001-12-26 AT AT01273341T patent/ATE457318T1/de not_active IP Right Cessation
- 2001-12-26 JP JP2002558389A patent/JP4450555B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1354896A1 (de) | 2003-10-22 |
EP1354896B1 (de) | 2010-02-10 |
US20040136982A1 (en) | 2004-07-15 |
JPWO2002057316A1 (ja) | 2004-05-20 |
ATE457318T1 (de) | 2010-02-15 |
EP1354896A4 (de) | 2004-06-16 |
US7592005B2 (en) | 2009-09-22 |
WO2002057316A1 (fr) | 2002-07-25 |
JP4450555B2 (ja) | 2010-04-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |