DE60134414D1 - 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden - Google Patents
4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methodenInfo
- Publication number
- DE60134414D1 DE60134414D1 DE60134414T DE60134414T DE60134414D1 DE 60134414 D1 DE60134414 D1 DE 60134414D1 DE 60134414 T DE60134414 T DE 60134414T DE 60134414 T DE60134414 T DE 60134414T DE 60134414 D1 DE60134414 D1 DE 60134414D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- related methods
- pyrimidinamine derivatives
- pyrimidinamine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22379100P | 2000-08-08 | 2000-08-08 | |
| PCT/US2001/024659 WO2002012198A2 (en) | 2000-08-08 | 2001-08-06 | 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60134414D1 true DE60134414D1 (de) | 2008-07-24 |
Family
ID=22837982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60134414T Expired - Lifetime DE60134414D1 (de) | 2000-08-08 | 2001-08-06 | 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20030008883A1 (de) |
| EP (1) | EP1313713B1 (de) |
| JP (1) | JP2004505952A (de) |
| CN (1) | CN1468225A (de) |
| AR (1) | AR031601A1 (de) |
| AT (1) | ATE398109T1 (de) |
| AU (1) | AU2001281120A1 (de) |
| BR (1) | BR0113165A (de) |
| CA (1) | CA2419030A1 (de) |
| DE (1) | DE60134414D1 (de) |
| HK (1) | HK1054033A1 (de) |
| IL (1) | IL154240A0 (de) |
| MX (1) | MXPA03001226A (de) |
| NZ (1) | NZ524100A (de) |
| WO (1) | WO2002012198A2 (de) |
| ZA (1) | ZA200301868B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2355472T3 (es) | 2002-05-22 | 2011-03-28 | Amgen Inc. | Derivados de aminopirimidina para su uso como ligandos del receptor vaniloide para el tratamiento del dolor. |
| US7419984B2 (en) * | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| JP2007523875A (ja) * | 2003-07-15 | 2007-08-23 | ニューロジェン・コーポレーション | バニロイド受容体リガンドとしての置換ピリミジン−４−イルアミン類縁体 |
| CN1826328A (zh) * | 2003-07-22 | 2006-08-30 | 神经能质公司 | 经取代的吡啶－2－基胺类似物 |
| RU2377241C2 (ru) * | 2003-11-24 | 2009-12-27 | Ф.Хоффманн-Ля Рош Аг | Производные пиразоло-имидазопиримидина, обладающие антагонистической активностью в отношении кортикотропин-рилизинг фактора (crf) |
| CA2556239A1 (en) * | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| MXPA06012613A (es) | 2004-05-07 | 2007-01-31 | Amgen Inc | Derivados heterociclicos nitrogenados como moduladores de proteina cinasa y uso para el tratamiento de angiogenesis y cancer. |
| CN1972934A (zh) | 2004-06-28 | 2007-05-30 | 奥坦纳医药公司 | 4,6－二取代嘧啶及其作为蛋白激酶抑制剂的用途 |
| US7314933B2 (en) | 2004-10-22 | 2008-01-01 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| HU0900798D0 (en) | 2009-12-21 | 2010-03-01 | Vichem Chemie Kutato Kft | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| US20130109714A1 (en) * | 2010-03-26 | 2013-05-02 | National University Corporation Hokkaido University | Neurodegenerative disease therapeutic agent |
| CA2882733C (en) * | 2012-08-23 | 2021-07-27 | Virostatics Srl | Novel 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents |
| CA2932608C (en) * | 2013-12-11 | 2023-02-14 | Biogen Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| SG11202003441VA (en) * | 2017-10-17 | 2020-05-28 | Merck Patent Gmbh | PYRIMIDINE ΤΒΚ/ΙΚΚε INHIBITOR COMPOUNDS AND USES THEREOF |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5068271A (en) * | 1988-09-21 | 1991-11-26 | Uniroyal Chemical Company, Inc. | Arylenediamine substituted pyrimidines compositions |
| DE3905364A1 (de) * | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| US5506231A (en) * | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
| AU692484B2 (en) * | 1993-10-12 | 1998-06-11 | Du Pont Pharmaceuticals Company | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof |
| ATE232521T1 (de) * | 1998-03-27 | 2003-02-15 | Janssen Pharmaceutica Nv | Hiv hemmende pyrimidin derivate |
| ES2221440T3 (es) * | 1998-10-16 | 2004-12-16 | Daiichi Suntory Pharma Co Ltd | Derivados de acido aminofenoxiacetico como neuroprotectores. |
| JP2003146987A (ja) * | 1999-05-31 | 2003-05-21 | Dainippon Pharmaceut Co Ltd | ２−アリールプリン−９−アセトアミド誘導体 |
-
2001
- 2001-08-06 DE DE60134414T patent/DE60134414D1/de not_active Expired - Lifetime
- 2001-08-06 IL IL15424001A patent/IL154240A0/xx unknown
- 2001-08-06 WO PCT/US2001/024659 patent/WO2002012198A2/en active Application Filing
- 2001-08-06 US US09/922,874 patent/US20030008883A1/en not_active Abandoned
- 2001-08-06 EP EP01959581A patent/EP1313713B1/de not_active Expired - Lifetime
- 2001-08-06 JP JP2002518176A patent/JP2004505952A/ja active Pending
- 2001-08-06 NZ NZ524100A patent/NZ524100A/en not_active Application Discontinuation
- 2001-08-06 AU AU2001281120A patent/AU2001281120A1/en not_active Abandoned
- 2001-08-06 CN CNA018166938A patent/CN1468225A/zh active Pending
- 2001-08-06 BR BR0113165-6A patent/BR0113165A/pt not_active IP Right Cessation
- 2001-08-06 CA CA002419030A patent/CA2419030A1/en not_active Abandoned
- 2001-08-06 AT AT01959581T patent/ATE398109T1/de not_active IP Right Cessation
- 2001-08-06 MX MXPA03001226A patent/MXPA03001226A/es active IP Right Grant
- 2001-08-08 AR ARP010103803A patent/AR031601A1/es unknown
-
2003
- 2003-03-06 ZA ZA200301868A patent/ZA200301868B/en unknown
- 2003-03-25 US US10/396,158 patent/US20030212079A1/en not_active Abandoned
- 2003-03-25 US US10/395,971 patent/US20040006094A1/en not_active Abandoned
- 2003-09-08 HK HK03106375.9A patent/HK1054033A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001281120A1 (en) | 2002-02-18 |
| IL154240A0 (en) | 2003-07-31 |
| WO2002012198A3 (en) | 2002-06-06 |
| EP1313713B1 (de) | 2008-06-11 |
| US20040006094A1 (en) | 2004-01-08 |
| WO2002012198A2 (en) | 2002-02-14 |
| EP1313713A2 (de) | 2003-05-28 |
| US20030008883A1 (en) | 2003-01-09 |
| MXPA03001226A (es) | 2004-09-10 |
| US20030212079A1 (en) | 2003-11-13 |
| CN1468225A (zh) | 2004-01-14 |
| AR031601A1 (es) | 2003-09-24 |
| ZA200301868B (en) | 2004-06-25 |
| ATE398109T1 (de) | 2008-07-15 |
| JP2004505952A (ja) | 2004-02-26 |
| BR0113165A (pt) | 2003-07-15 |
| NZ524100A (en) | 2005-01-28 |
| CA2419030A1 (en) | 2002-02-14 |
| HK1054033A1 (zh) | 2003-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |