DE60127820D1 - Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit - Google Patents

Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit

Info

Publication number
DE60127820D1
DE60127820D1 DE60127820T DE60127820T DE60127820D1 DE 60127820 D1 DE60127820 D1 DE 60127820D1 DE 60127820 T DE60127820 T DE 60127820T DE 60127820 T DE60127820 T DE 60127820T DE 60127820 D1 DE60127820 D1 DE 60127820D1
Authority
DE
Germany
Prior art keywords
taxol
production
starting materials
supercritical liquid
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60127820T
Other languages
English (en)
Other versions
DE60127820T2 (de
Inventor
Jin Woong Kim
Young Hae Choi
Ki Pung Yoo
Min Jeong Noh
Joo Hee Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanwha Chemical Corp
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Publication of DE60127820D1 publication Critical patent/DE60127820D1/de
Application granted granted Critical
Publication of DE60127820T2 publication Critical patent/DE60127820T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60127820T 2000-02-25 2001-02-24 Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit Expired - Lifetime DE60127820T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020000009255A KR100666652B1 (ko) 2000-02-25 2000-02-25 식물 원료로부터 초임계 유체를 이용하여 탁솔을 제조하는방법
KR2000009255 2000-02-25
PCT/KR2001/000282 WO2001062753A1 (en) 2000-02-25 2001-02-24 Method and apparatus for preparing taxol using supercritical fluid from source materials

Publications (2)

Publication Number Publication Date
DE60127820D1 true DE60127820D1 (de) 2007-05-24
DE60127820T2 DE60127820T2 (de) 2007-12-27

Family

ID=19649887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60127820T Expired - Lifetime DE60127820T2 (de) 2000-02-25 2001-02-24 Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit

Country Status (8)

Country Link
US (1) US6503396B2 (de)
EP (1) EP1261596B1 (de)
KR (1) KR100666652B1 (de)
CN (1) CN1205197C (de)
AT (1) ATE359280T1 (de)
AU (1) AU2001237736A1 (de)
DE (1) DE60127820T2 (de)
WO (1) WO2001062753A1 (de)

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US6648609B2 (en) * 2002-04-05 2003-11-18 Berger Instruments, Inc. Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
CA2559077A1 (en) * 2004-03-16 2005-09-22 Universite Laval Process for extraction of diterpenes and triterpenes from biomaterial
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US20060074254A1 (en) * 2004-09-30 2006-04-06 Zisheng Zhang Process for extracting taxanes
EP1792542A1 (de) * 2005-12-02 2007-06-06 SCF Technologies A/S Verfahren zur Hestellung eines einen verringerten Inhalt an Spezies enthaltenden vorbereiteten Lebensmittels
WO2007092827A2 (en) * 2006-02-08 2007-08-16 Waters Investments Limited Improved separation method
EP1818328A1 (de) * 2006-02-10 2007-08-15 6570763 Canada Inc. Chromatographisches Verfahren zur Isolierung und Reinigung von Taxanderivaten
JP5060791B2 (ja) * 2007-01-26 2012-10-31 独立行政法人森林総合研究所 木材の乾燥方法、木材への薬剤浸透方法及び乾燥装置
US8215922B2 (en) 2008-06-24 2012-07-10 Aurora Sfc Systems, Inc. Compressible fluid pumping system for dynamically compensating compressible fluids over large pressure ranges
US9163618B2 (en) 2008-06-24 2015-10-20 Agilent Technologies, Inc. Automated conversion between SFC and HPLC
US8419936B2 (en) * 2010-03-23 2013-04-16 Agilent Technologies, Inc. Low noise back pressure regulator for supercritical fluid chromatography
US8293111B2 (en) * 2010-05-17 2012-10-23 Uti Limited Partnership Apparatus, system, and method for chromatography using a water stationary phase
AU2011303892B2 (en) * 2010-09-15 2016-05-26 Basf Plant Science Company Gmbh Extraction device and method for extracting ingredients from a biological sample
AU2011332011B2 (en) 2010-11-23 2017-01-12 Lexington Pharmaceuticals Laboratories, Llc Low temperature chlorination of carbohydrates
CN102649776A (zh) * 2011-02-25 2012-08-29 苏州宝泽堂医药科技有限公司 一种高乌甲素的制备方法
SG2013049648A (en) 2011-10-14 2014-12-30 Lexington Pharmaceuticals Lab Llc Chlorination of carbohydrates and carbohydrate derivatives
CN103030673B (zh) * 2012-12-31 2015-07-22 浙江大学宁波理工学院 一种从南方红豆杉叶中提取杨梅素-3-o-芸香糖的方法
WO2014150976A1 (en) 2013-03-15 2014-09-25 Cba Pharma, Inc. Supercritical fluid extraction of bis-benzyl isoquinolines
CN104059034A (zh) * 2014-06-06 2014-09-24 庞作仁 超声波逆流无毒提取紫杉醇的生产***及工艺
US10857482B1 (en) * 2016-12-07 2020-12-08 Rien Havens Botanical super heated processing equipment
CN110305079A (zh) * 2019-06-12 2019-10-08 苏州岚云医药科技有限公司 一种抗癌药物超临界流体萃取提纯法
US12023601B2 (en) 2019-09-09 2024-07-02 Alden Botanica LLC Carbon dioxide extraction processes, devices, methods, and systems
US20220315859A1 (en) * 2019-09-13 2022-10-06 Dalrada Health Products Plant oil extraction device
CN112979594B (zh) * 2021-02-26 2021-12-14 南通科鑫超临界设备有限公司 一种穿心莲内酯超临界萃取工艺
CN113896695B (zh) * 2021-05-26 2023-12-01 四川杉宝生物科技有限公司 从曼地亚红豆杉中同时提取三尖杉宁碱和紫杉醇的方法
CN113831306A (zh) * 2021-09-30 2021-12-24 王强 一种超临界co2流体萃取法提取紫杉醇的方法

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US4683063A (en) * 1985-05-08 1987-07-28 Vitamins, Inc. Method for carrying out extractions in subterranean well
US4898673A (en) * 1987-07-11 1990-02-06 Vitamins, Inc. Dynamic supercritical fluid extraction system
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
ATE180477T1 (de) * 1991-04-19 1999-06-15 Univ Mississippi Verfahren und zubereitungen zur isolierung von taxanen
CA2072400C (en) * 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
KR0133947B1 (ko) 1992-09-15 1998-04-22 윤종용 음성채널절환장치
US5854064A (en) * 1996-07-31 1998-12-29 Aphios Corporation Methods for fractionation of biologically-derived materials
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
KR0132275B1 (ko) * 1994-04-14 1998-04-17 한동근 탁솔의 향류 초임계 추출 및 정제방법과 그의 장치
KR100278917B1 (ko) 1994-11-21 2001-01-15 김영환 반도체 소자의 콘택 마스크 제조방법
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
KR100208656B1 (ko) * 1996-11-19 1999-07-15 변상요 초임계유체를 이용한 추출과 정제의 온라인 연속공정에 의한 탁솔의 제조장치
CN1099899C (zh) 1997-12-31 2003-01-29 孙传经 生产型超临界二氧化碳制备色谱及其用途
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6291241B1 (en) * 1999-03-29 2001-09-18 Trevor Percival Castor Methods for making Hypericum fractions and St. John's Wort products

Also Published As

Publication number Publication date
CN1205197C (zh) 2005-06-08
US20020000410A1 (en) 2002-01-03
WO2001062753A1 (en) 2001-08-30
KR20010084323A (ko) 2001-09-06
KR100666652B1 (ko) 2007-01-09
EP1261596A4 (de) 2004-06-30
US6503396B2 (en) 2003-01-07
ATE359280T1 (de) 2007-05-15
DE60127820T2 (de) 2007-12-27
EP1261596A1 (de) 2002-12-04
AU2001237736A1 (en) 2001-09-03
CN1406235A (zh) 2003-03-26
EP1261596B1 (de) 2007-04-11

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