DE60115878D1 - Schmerz signalisierende moleküle - Google Patents

Schmerz signalisierende moleküle

Info

Publication number
DE60115878D1
DE60115878D1 DE60115878T DE60115878T DE60115878D1 DE 60115878 D1 DE60115878 D1 DE 60115878D1 DE 60115878 T DE60115878 T DE 60115878T DE 60115878 T DE60115878 T DE 60115878T DE 60115878 D1 DE60115878 D1 DE 60115878D1
Authority
DE
Germany
Prior art keywords
expressed
signaling molecules
pain signaling
novel
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60115878T
Other languages
English (en)
Other versions
DE60115878T2 (de
Inventor
J Anderson
Xinzhong Dong
Mark Zylka
Sang-Kyou Han
Melvin Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/704,707 external-priority patent/US7691604B1/en
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of DE60115878D1 publication Critical patent/DE60115878D1/de
Application granted granted Critical
Publication of DE60115878T2 publication Critical patent/DE60115878T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60115878T 2000-05-04 2001-05-04 Schmerz signalisierende moleküle Expired - Lifetime DE60115878T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US20202700P 2000-05-04 2000-05-04
US202027P 2000-05-04
US22234400P 2000-08-01 2000-08-01
US222344P 2000-08-01
US09/704,707 US7691604B1 (en) 2000-05-04 2000-11-03 MRG polypeptides and nucleic acids encoding the same
US704707 2000-11-03
US28549301P 2001-04-19 2001-04-19
US285493P 2001-04-19
PCT/US2001/014519 WO2001083555A2 (en) 2000-05-04 2001-05-04 Pain signaling molecules

Publications (2)

Publication Number Publication Date
DE60115878D1 true DE60115878D1 (de) 2006-01-19
DE60115878T2 DE60115878T2 (de) 2006-08-24

Family

ID=27498450

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60115878T Expired - Lifetime DE60115878T2 (de) 2000-05-04 2001-05-04 Schmerz signalisierende moleküle

Country Status (7)

Country Link
EP (1) EP1280904B1 (de)
JP (1) JP2003533188A (de)
AT (1) ATE312919T1 (de)
AU (1) AU2001259508A1 (de)
CA (1) CA2407219A1 (de)
DE (1) DE60115878T2 (de)
WO (1) WO2001083555A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020064822A1 (en) * 2000-03-13 2002-05-30 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
US20030092035A1 (en) * 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
DE60135773D1 (en) 2000-10-17 2008-10-23 Astrazeneca Ab Assays
US20040076951A1 (en) * 2000-10-25 2004-04-22 Ming-Hui Wei Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof
US20040143092A1 (en) * 2001-02-08 2004-07-22 Alex Smolyar Regulation of human dorsal root receptor-like g protein-coupled receptor
DE10225443A1 (de) 2002-06-08 2003-12-18 Aventis Pharma Gmbh Verfahren zur Identifizierung von Agonisten oder Antagonisten für den G-Protein gekoppelten Rezeptor mas like 1
WO2004039972A1 (ja) * 2002-10-29 2004-05-13 Takeda Pharmaceutical Company Limited Ｈｉ７ｔ２１３遺伝子導入動物および新規なｈｉ７ｔ２１３タンパク質およびそのｄｎａ
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
DE10310758A1 (de) * 2003-03-11 2004-09-23 Grünenthal GmbH Identifizierung von schmerzrelevanten Genen der SNSR (Sensory Neuron Specific Receptor)-Familie
WO2005003763A2 (en) * 2003-06-18 2005-01-13 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor 3 (mrgx3)
JP2007507538A (ja) 2003-10-02 2007-03-29 エラン ファーマシューティカルズ，インコーポレイテッド 疼痛軽減方法
WO2005114208A1 (en) * 2004-05-13 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas-related gene mrgd (mrgd)
WO2006005470A2 (en) * 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor e (mrge)
WO2006066599A2 (en) * 2004-12-22 2006-06-29 Rheoscience A/S Mas related g protein coupled receptors as drug targets
CN112266931B (zh) * 2020-10-15 2022-04-29 海湃泰克(北京)生物医药科技有限公司 特异性表达hMRGPRX4的转基因大鼠的构建方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704836D0 (sv) * 1997-12-22 1997-12-22 Astra Pharma Inc Novel receptor
JP2000023676A (ja) * 1998-07-14 2000-01-25 Asahi Chem Ind Co Ltd ７回膜貫通型受容体蛋白質ｅｒｇ５

Also Published As

Publication number Publication date
EP1280904A2 (de) 2003-02-05
WO2001083555A3 (en) 2002-05-02
JP2003533188A (ja) 2003-11-11
EP1280904B1 (de) 2005-12-14
CA2407219A1 (en) 2001-11-08
ATE312919T1 (de) 2005-12-15
DE60115878T2 (de) 2006-08-24
WO2001083555A2 (en) 2001-11-08
AU2001259508A1 (en) 2001-11-12

Similar Documents

Publication Publication Date Title
DE60115878D1 (de) Schmerz signalisierende moleküle
SE9704836D0 (sv) Novel receptor
ATE407144T1 (de) T1r-geschmacksrezeptoren und dafür kodierende gene
DE60237431D1 (de) Rezeptor-selektive cannabimimetische aminoalkylindole
DE60332269D1 (de) Vorrichtung zur gerichteten stimulation von nerven
DE60135229D1 (de) T1r-geschmacksrezeptoren und ihre kodierenden gene
HK1029595A1 (en) Cyclic antagonists of c5a receptors and g protein-coupled receptors
DE602005026169D1 (de) Tetrahydroisochinolinverbindungen zur behandlung von zns-erkrankungen
EA200501430A1 (ru) Лиганды каннабиноидных рецепторов и их применение
ATE369144T1 (de) Verfahren zur steigerung des haarwuchses durch wnt polypeptid
DE602004020072D1 (de) 1,2,3,4-tetrasubstituiertes indol zur behandlung von atemwegserkrankungen
DE602005027322D1 (de) Verwendung von antikörpern gegen tweak zur behandlung von schlaganfall
DE60304695D1 (de) 7-ARYLSULFONAMID-2,3,4,5-TETRAHYDRO-1H-BENZOiDöAZEPINE MIT 5-HT6 REZEPTOR AFFINITÄT ZUR BEHANDLUNG VON ZENTRALNERVENSYSTEMERKRANKUNGEN
HUP0402496A2 (hu) Módosított polipeptidek
NO20055563L (no) Midler for behandlingen av lavere abdominale lidelser
ATE457309T1 (de) Modulatoren von peripheren 5-ht-rezeptoren
DE69729730D1 (de) Transgene mäuse, die den leukämie inhibierungsfaktor exprimieren können
ATE418337T1 (de) Verwendung von dihydroimidazolonen zur behandlung von epilepsie bei hunden
DE60004473D1 (de) Verwendung von gaba-b rezeptor liganden zur herstellungen von medikamenten zur behandlung von neurodegenerativen erkrankungen
ATE356785T1 (de) Künstliches pflanzenreinigungssystem
EP1545195A4 (de) Tiermodell für perimenopause und menopause und verfahren zur einleitung von ovarialinsuffizienz
ATE378052T1 (de) Verwendung von galanthamin zur behandlung von krankheitserscheinungen des zentralen nervensystems aufgrund von intoxikationen mit psychotropen substanzen
DE502004010674D1 (de) Kinnkette
DE60033562D1 (de) Künstliche promotoren zür protein expression in pflanzen
ATE341322T1 (de) Verwendung von aminomethyl chromanen zur behandlung der nebenwirkungen von neuroleptika

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8370 Indication related to discontinuation of the patent is to be deleted