DE60106497D1 - Ein verfahren zur herstellung von natrium fosinopril - Google Patents

Ein verfahren zur herstellung von natrium fosinopril

Info

Publication number: DE60106497D1
Authority: DE; Germany
Prior art keywords: fosinopril; producing sodium; sodium fosinopril; mixture; desired isomer
Prior art date: 2001-04-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE2001606497

Other languages

English (en)

Inventor

Kumar Dubey

Saswata Lahiri

Vir Singh

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lupin Laboratories Ltd

Original Assignee

Lupin Laboratories Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-30

Filing date

2001-08-17

Publication date

2004-11-18

2001-08-17 Application filed by Lupin Laboratories Ltd filed Critical Lupin Laboratories Ltd

2004-11-18 Application granted granted Critical

2004-11-18 Publication of DE60106497D1 publication Critical patent/DE60106497D1/de

2021-08-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 title abstract 3
229960002490 fosinopril Drugs 0.000 title abstract 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1
239000011734 sodium Substances 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salts Chemical class 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)

DE2001606497 2001-04-30 2001-08-17 Ein verfahren zur herstellung von natrium fosinopril Expired - Lifetime DE60106497D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN411MU2001		2001-04-30
PCT/IN2001/000144 WO2002088149A2 (en)	2001-04-30	2001-08-17	A process for manufacture of fosinopril sodium
US10/297,224 US7078532B2 (en)	2001-04-30	2001-08-17	Process for manufacture of fosinopril sodium

Publications (1)

Publication Number	Publication Date
DE60106497D1 true DE60106497D1 (de)	2004-11-18

Family

ID=36575252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE2001606497 Expired - Lifetime DE60106497D1 (de)	2001-04-30	2001-08-17	Ein verfahren zur herstellung von natrium fosinopril

Country Status (7)

Country	Link
US (4)	US7078532B2 (de)
EP (1)	EP1383779B1 (de)
JP (1)	JP2004520440A (de)
AT (1)	ATE279423T1 (de)
CA (1)	CA2411876A1 (de)
DE (1)	DE60106497D1 (de)
WO (1)	WO2002088149A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2004520440A (ja) *	2001-04-30	2004-07-08	ルピンラボラトリーズリミティド	フォシノプリルナトリウムの製造方法
ES2195752B1 (es) *	2001-11-30	2004-10-16	Quimica Sintetica, S.A.	Procedimiento para la preparacion de polimorfos cristalinos de la sal sodica del fosinopril.
MXPA06014152A (es) *	2004-06-11	2007-01-29	Takeda Pharmaceutical	Metodo de amidacion novedoso, altamente selectivo.
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
CN107365268B (zh) *	2016-05-11	2021-02-05	常州制药厂有限公司	一种降压药福辛普利钠及其关键中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4337201A (en) *	1980-12-04	1982-06-29	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
US4873356A (en) *	1987-09-30	1989-10-10	E. R. Squibb & Sons, Inc.	Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby
US5008399A (en) *	1990-01-19	1991-04-16	E. R. Squibb & Sons, Inc.	Diastereoselective preparation of phosphinate esters
US5162543A (en) *	1990-02-16	1992-11-10	E. R. Squibb & Sons, Inc.	Selective processes for fosinopril polymorphs
JP2004520440A (ja) *	2001-04-30	2004-07-08	ルピンラボラトリーズリミティド	フォシノプリルナトリウムの製造方法

2001
- 2001-08-17 JP JP2002585447A patent/JP2004520440A/ja active Pending
- 2001-08-17 CA CA002411876A patent/CA2411876A1/en not_active Abandoned
- 2001-08-17 EP EP01967669A patent/EP1383779B1/de not_active Expired - Lifetime
- 2001-08-17 WO PCT/IN2001/000144 patent/WO2002088149A2/en active IP Right Grant
- 2001-08-17 US US10/297,224 patent/US7078532B2/en not_active Expired - Fee Related
- 2001-08-17 AT AT01967669T patent/ATE279423T1/de not_active IP Right Cessation
- 2001-08-17 DE DE2001606497 patent/DE60106497D1/de not_active Expired - Lifetime
2005
- 2005-08-17 US US11/206,259 patent/US20060160772A1/en not_active Abandoned
- 2005-11-09 US US11/270,349 patent/US20060063939A1/en not_active Abandoned
- 2005-11-09 US US11/270,358 patent/US20060122401A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060063939A1 (en)	2006-03-23
CA2411876A1 (en)	2002-11-07
US20040225127A1 (en)	2004-11-11
WO2002088149A3 (en)	2003-06-05
JP2004520440A (ja)	2004-07-08
US20060160772A1 (en)	2006-07-20
US7078532B2 (en)	2006-07-18
ATE279423T1 (de)	2004-10-15
WO2002088149A2 (en)	2002-11-07
US20060122401A1 (en)	2006-06-08
EP1383779B1 (de)	2004-10-13
EP1383779A2 (de)	2004-01-28

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Legal Events

Date	Code	Title	Description
2005-09-15	8332	No legal effect for de