DE60044717D1 - Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen - Google Patents

Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen

Info

Publication number
DE60044717D1
DE60044717D1 DE60044717T DE60044717T DE60044717D1 DE 60044717 D1 DE60044717 D1 DE 60044717D1 DE 60044717 T DE60044717 T DE 60044717T DE 60044717 T DE60044717 T DE 60044717T DE 60044717 D1 DE60044717 D1 DE 60044717D1
Authority
DE
Germany
Prior art keywords
recipient
prevention
treatment
rejection
xenografts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044717T
Other languages
English (en)
Inventor
Hendrik J Schuurman
Emanuele Luigi Cozzi
Francoise Richard
Guy Taccard
David James White
Peter John Friend
John Wallwork
Paolo Brenner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910835.9A external-priority patent/GB9910835D0/en
Priority claimed from GBGB9925443.5A external-priority patent/GB9925443D0/en
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60044717D1 publication Critical patent/DE60044717D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DE60044717T 1999-05-10 2000-05-10 Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen Expired - Lifetime DE60044717D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9910835.9A GB9910835D0 (en) 1999-05-10 1999-05-10 Organic compounds
GBGB9925443.5A GB9925443D0 (en) 1999-10-27 1999-10-27 Organic compounds
PCT/EP2000/004250 WO2000067773A2 (en) 1999-05-10 2000-05-10 Combinations of immunosupressive agents for the treatment or prevention of graft rejections

Publications (1)

Publication Number Publication Date
DE60044717D1 true DE60044717D1 (de) 2010-09-02

Family

ID=26315533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60044717T Expired - Lifetime DE60044717D1 (de) 1999-05-10 2000-05-10 Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen

Country Status (7)

Country Link
US (5) US20020132764A1 (de)
EP (2) EP1181034B1 (de)
JP (1) JP2002544167A (de)
AT (1) ATE474590T1 (de)
AU (1) AU4565000A (de)
DE (1) DE60044717D1 (de)
WO (1) WO2000067773A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1208847E (pt) * 1996-07-30 2007-07-24 Novartis Ag Composições farmacêuticas para o tratamento da rejeição de transplantes, doenças autoimunes ou inflamatórias compreendendo ciclosporina a e 40-0-(2-hidroxietil)-rapamicina
AU3095601A (en) 2000-01-14 2001-07-24 Univ Pennsylvania O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disorders
GB0124953D0 (en) * 2001-10-17 2001-12-05 Novartis Ag Organic Compounds
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
AR045957A1 (es) * 2003-10-03 2005-11-16 Novartis Ag Composicion farmaceutica y combinacion
CA2924681C (en) 2013-09-24 2019-12-31 Giner, Inc. System for gas treatment of a cell implant
US11033666B2 (en) 2016-11-15 2021-06-15 Giner Life Sciences, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
US11642501B2 (en) 2017-05-04 2023-05-09 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5178858A (en) * 1987-12-02 1993-01-12 Reichert Thomas A Method for prevention of graft versus host disease
US5135934A (en) 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
ATE232730T1 (de) 1991-08-23 2003-03-15 Alberta Res Council Verfahren und zusammensetzungen zur verhinderung der antikörper-vermittelten abstossung von xenogenen transplantaten
US5516781A (en) * 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5843452A (en) * 1992-11-09 1998-12-01 Pharmagenesis, Inc. Immunotherapy composition and method
EP0804734B1 (de) 1994-05-13 2005-05-04 Miltenyi Biotec GmbH An protein gebundene sterile und pyrogenfreie säulen zum binden und entfernen von substanzen aus blut
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
IL115742A (en) 1994-10-26 2000-06-01 Novartis Ag Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
US5697109A (en) 1994-10-28 1997-12-16 Barton Medical Corporation Patient transport system
US5631282A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. Triterpenes
BE1009856A5 (fr) 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
GB9601120D0 (en) 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
ID18663A (id) 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
PT1208847E (pt) * 1996-07-30 2007-07-24 Novartis Ag Composições farmacêuticas para o tratamento da rejeição de transplantes, doenças autoimunes ou inflamatórias compreendendo ciclosporina a e 40-0-(2-hidroxietil)-rapamicina
GB9619706D0 (en) 1996-09-20 1996-11-06 Pharmacia Spa Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole comp und
US5962415A (en) * 1996-09-20 1999-10-05 Bristol-Myers Squibb Co. Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods of use thereof
WO1998047915A1 (en) 1997-04-18 1998-10-29 Novartis Ag Neoglycoproteins
WO1999003336A1 (fr) 1997-07-14 1999-01-28 Nippon Meat Packers, Inc. Mammiferes transgeniques

Also Published As

Publication number Publication date
ATE474590T1 (de) 2010-08-15
AU4565000A (en) 2000-11-21
US20080199478A1 (en) 2008-08-21
US20020132764A1 (en) 2002-09-19
US20050277585A1 (en) 2005-12-15
US8435520B2 (en) 2013-05-07
EP1980263A1 (de) 2008-10-15
US20110142953A1 (en) 2011-06-16
EP1181034A2 (de) 2002-02-27
WO2000067773A2 (en) 2000-11-16
JP2002544167A (ja) 2002-12-24
EP1181034B1 (de) 2010-07-21
US20070060511A1 (en) 2007-03-15
WO2000067773A3 (en) 2001-06-28

Similar Documents

Publication Publication Date Title
ATE319312T1 (de) Suppressorzellen zur prävention und behandlung von immunantworten bei transplantationen
ATE269354T1 (de) Depsipeptide und deren analoge zur verwendung als immunosuppressiva
ATE340586T1 (de) Pharmazeutische zusammensetzungen zur behandlung der transplantatabstossung sowie der autoimmun- oder entzündlichen zustände
MY113490A (en) Modified anti-icam-1 antibodies and their use in the treatment of inflammation
NL300056I1 (nl) Toepassing van rapamycine en derivaten en vóórgeneesmiddelen daarvan bij de bereiding van een geneesmiddel voor het remmen van de afstoting van een transplantaat in zoogdieren.
ES2110320T3 (es) Dispositivo de tratamiento de la superficie de carrocerias de vehiculos.
ATE424893T1 (de) Behandlung und vorbeugung von insulin- produzierende zelltransplantatabstossung
IL156917A0 (en) Method and apparatus to remove substances from vessels of the heart and other parts of the body to minimize or avoid renal or other harm or dysfunction
ATE350019T1 (de) Verfahren zur behandlung von kapseln und trockenen gepulverten pharmazeutischen formulierungen
ATE265857T1 (de) Pharmazeutische oder diätetische zusammensetzung zur prävention oder behandlung von hyperoxalurie
MXPA03008820A (es) Compuestos generadores de monoxido de carbono, para el tratamiento de desordenes vasculares, inflamatorios e inmunologicos.
DE60044717D1 (de) Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen
WO2004031129A3 (en) Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
DE60020727D1 (de) Zusammensetzung zur vorbeugung und behandlung von transplantatabstossung
CA2060474A1 (en) Pharmaceutical use
DE69626816D1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
WO1999056666A8 (en) The treatment of sexual dysfunction in certain patient groups
ATE294582T1 (de) Verwendung von alpha-1-adrenorezeptor- antagonisten zur herstellung eines medikaments für die vorbeugung und die behandlung von krebs
DE69737088D1 (de) Therapeutisches agens zur behandlung von fiv infektionen
IT1283589B1 (it) Procedimento per il trattamento di rifiuti solidi urbani e assimilati, nonche' impianto per la realizzazione del procedimento
ATE340584T1 (de) Zusammensetzung und verfahren zur behandlung chronischer allograft-abstossung
RU2002120789A (ru) Способ лечения инфекции синтетического сосудистого протеза
ATE283063T1 (de) Allogene und xenogene transplantation
RU99112339A (ru) Способ лечения туберкулеза периферических лимфатических узлов
RU98109220A (ru) Способ лечения экземы