DE60043509D1 - Biosynthese von Polyketidsynthase-Substrate - Google Patents
Biosynthese von Polyketidsynthase-SubstrateInfo
- Publication number
- DE60043509D1 DE60043509D1 DE60043509T DE60043509T DE60043509D1 DE 60043509 D1 DE60043509 D1 DE 60043509D1 DE 60043509 T DE60043509 T DE 60043509T DE 60043509 T DE60043509 T DE 60043509T DE 60043509 D1 DE60043509 D1 DE 60043509D1
- Authority
- DE
- Germany
- Prior art keywords
- polyketides
- biosynthesis
- polyketide synthase
- enzymes
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15909099P | 1999-10-13 | 1999-10-13 | |
US20608200P | 2000-05-18 | 2000-05-18 | |
US23237900P | 2000-09-14 | 2000-09-14 | |
PCT/US2000/028573 WO2001027306A2 (en) | 1999-10-13 | 2000-10-13 | Biosynthesis of polyketide synthase substrates |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60043509D1 true DE60043509D1 (de) | 2010-01-21 |
Family
ID=27388268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60043509T Expired - Lifetime DE60043509D1 (de) | 1999-10-13 | 2000-10-13 | Biosynthese von Polyketidsynthase-Substrate |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1222304B1 (de) |
JP (1) | JP5142435B2 (de) |
AT (1) | ATE451468T1 (de) |
AU (1) | AU780784B2 (de) |
CA (1) | CA2383965A1 (de) |
DE (1) | DE60043509D1 (de) |
ES (1) | ES2335385T3 (de) |
IL (1) | IL148439A0 (de) |
MX (1) | MXPA02003754A (de) |
NZ (1) | NZ517557A (de) |
WO (1) | WO2001027306A2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6627427B1 (en) | 1999-10-25 | 2003-09-30 | Kosan Biosciences, Inc. | Heterologous production of 15-methyl-6-deoxyerthronolide B |
ES2283323T3 (es) | 1999-10-27 | 2007-11-01 | Kosan Biosciences, Inc. | Produccion heterologa de policetidos. |
WO2002068613A1 (en) * | 2001-02-28 | 2002-09-06 | The Board Of Trustees Of The Leland Stanford Junior University | Biosynthesis of polyketide synthase substrates |
AU2003253949A1 (en) | 2002-07-15 | 2004-02-02 | Kosan Biosciences, Inc. | Metabolic pathways for starter units in polyketide biosynthesis |
SE532380C2 (sv) | 2008-09-23 | 2009-12-29 | Syntune Ab | Vågledare för utkoppling med låg reflex. |
US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
CN106834377B (zh) * | 2017-03-07 | 2020-05-05 | 鲁南制药集团股份有限公司 | 一种生产埃博霉素b的方法 |
CN110157756B (zh) * | 2019-03-11 | 2022-03-29 | 安徽大学 | 一种通过改造糖多孢红霉菌sace_0303基因提高红霉素产量的方法 |
CN111138444B (zh) * | 2020-01-08 | 2022-05-03 | 山东大学 | 一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098837A (en) | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
DK0725778T3 (da) * | 1993-09-20 | 2001-12-17 | Univ Leland Stanford Junior | Rekombinant produktion af hidtil ukendte polyketider |
US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5622866A (en) | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
ATE286133T1 (de) | 1995-07-06 | 2005-01-15 | Univ Leland Stanford Junior | Zellfreie synthese von polyketiden |
AU6655496A (en) * | 1995-08-11 | 1997-03-12 | Novo Nordisk A/S | Method for preparing polypeptide variants |
JP4709333B2 (ja) | 1995-10-13 | 2011-06-22 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | ホスホパンテテイニルトランスフェラーゼおよびその使用 |
US5998194A (en) | 1995-12-21 | 1999-12-07 | Abbott Laboratories | Polyketide-associated sugar biosynthesis genes |
WO1998007868A1 (en) | 1996-08-20 | 1998-02-26 | Novartis Ag | Rifamycin biosynthesis gene cluster |
US5834458A (en) | 1996-10-09 | 1998-11-10 | Eli Lilly And Company | Heterocyclic compounds and their use |
US6033883A (en) | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
WO1998027263A1 (en) * | 1996-12-18 | 1998-06-25 | E.I. Du Pont De Nemours And Company | Durable hydrophilic polymer coatings |
WO1998041628A1 (en) * | 1997-03-19 | 1998-09-24 | Zymogenetics, Inc. | Secreted salivary zsig32 polypeptides |
EP1029076A4 (de) * | 1997-10-15 | 2002-03-06 | Diversa Inc | Screening für neue verbindungen, die biologische interaktionen regulieren |
US7157615B2 (en) * | 1998-03-17 | 2007-01-02 | Nexia Biotechnologies, Inc. | Production of biofilaments in transgenic animals |
CA2343880C (en) * | 1998-10-02 | 2008-08-26 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant dna constructs therefor |
-
2000
- 2000-10-13 AT AT00972196T patent/ATE451468T1/de not_active IP Right Cessation
- 2000-10-13 JP JP2001530509A patent/JP5142435B2/ja not_active Expired - Lifetime
- 2000-10-13 MX MXPA02003754A patent/MXPA02003754A/es active IP Right Grant
- 2000-10-13 IL IL14843900A patent/IL148439A0/xx unknown
- 2000-10-13 EP EP00972196A patent/EP1222304B1/de not_active Revoked
- 2000-10-13 CA CA002383965A patent/CA2383965A1/en not_active Abandoned
- 2000-10-13 ES ES00972196T patent/ES2335385T3/es not_active Expired - Lifetime
- 2000-10-13 AU AU10892/01A patent/AU780784B2/en not_active Ceased
- 2000-10-13 NZ NZ517557A patent/NZ517557A/en unknown
- 2000-10-13 WO PCT/US2000/028573 patent/WO2001027306A2/en active IP Right Grant
- 2000-10-13 DE DE60043509T patent/DE60043509D1/de not_active Expired - Lifetime
- 2000-10-13 EP EP09172573.9A patent/EP2135955B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2383965A1 (en) | 2001-04-19 |
ATE451468T1 (de) | 2009-12-15 |
EP1222304A2 (de) | 2002-07-17 |
EP2135955A1 (de) | 2009-12-23 |
AU780784B2 (en) | 2005-04-14 |
ES2335385T3 (es) | 2010-03-26 |
NZ517557A (en) | 2004-05-28 |
WO2001027306A3 (en) | 2002-02-21 |
EP2135955B1 (de) | 2013-07-31 |
IL148439A0 (en) | 2002-09-12 |
WO2001027306A2 (en) | 2001-04-19 |
EP1222304B1 (de) | 2009-12-09 |
JP2003511085A (ja) | 2003-03-25 |
MXPA02003754A (es) | 2003-10-14 |
AU1089201A (en) | 2001-04-23 |
JP5142435B2 (ja) | 2013-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |