DE60042552D1 - Metabolische manipulation der produktion von aminosäuren - Google Patents

Metabolische manipulation der produktion von aminosäuren

Info

Publication number
DE60042552D1
DE60042552D1 DE60042552T DE60042552T DE60042552D1 DE 60042552 D1 DE60042552 D1 DE 60042552D1 DE 60042552 T DE60042552 T DE 60042552T DE 60042552 T DE60042552 T DE 60042552T DE 60042552 D1 DE60042552 D1 DE 60042552D1
Authority
DE
Germany
Prior art keywords
production
amino acids
metabolic manipulation
metabolic
manipulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042552T
Other languages
English (en)
Inventor
John P Rayapati
Corey M Crafton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Archer Daniels Midland Co
Original Assignee
Archer Daniels Midland Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archer Daniels Midland Co filed Critical Archer Daniels Midland Co
Application granted granted Critical
Publication of DE60042552D1 publication Critical patent/DE60042552D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60042552T 1999-08-02 2000-08-02 Metabolische manipulation der produktion von aminosäuren Expired - Lifetime DE60042552D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14637999P 1999-08-02 1999-08-02
PCT/US2000/020979 WO2001009286A1 (en) 1999-08-02 2000-08-02 Metabolic engineering of amino acid production

Publications (1)

Publication Number Publication Date
DE60042552D1 true DE60042552D1 (de) 2009-08-27

Family

ID=22517109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042552T Expired - Lifetime DE60042552D1 (de) 1999-08-02 2000-08-02 Metabolische manipulation der produktion von aminosäuren

Country Status (12)

Country Link
US (2) US7323321B2 (de)
EP (1) EP1200553B1 (de)
JP (3) JP2003506030A (de)
KR (1) KR100815041B1 (de)
CN (1) CN1367823A (de)
AU (1) AU779019B2 (de)
BR (1) BR0012963B1 (de)
CA (1) CA2380613C (de)
DE (1) DE60042552D1 (de)
MX (1) MXPA02001174A (de)
NZ (1) NZ516893A (de)
WO (1) WO2001009286A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063314A1 (de) * 2000-12-20 2002-07-04 Degussa Neue für das ilvE-Gen kodierende Nukleotidsequenzen
BR0304860A (pt) * 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
AR058584A1 (es) 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
EP2262894B1 (de) 2008-03-03 2014-07-09 Global Bio-Chem Technology Group Company Limited Rekombinanter mikroorganismus und verfahren zur herstellung von l-lysin
DE102010003419B4 (de) 2010-03-30 2019-09-12 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von L-Ornithin
CN103945931B (zh) 2011-09-26 2017-03-22 基因技术股份公司 高效的小体积核酸合成
WO2014153188A2 (en) 2013-03-14 2014-09-25 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
AU2012333515B2 (en) * 2011-11-02 2015-07-16 Ajinomoto Co., Inc. Method for secreting and producing proteins
AU2012333451B2 (en) 2011-11-02 2015-05-21 Ajinomoto Co., Inc. Method for secretory production of protein
CN102604881B (zh) * 2012-03-31 2013-12-18 福建省麦丹生物集团有限公司 生产l-异亮氨酸的工程菌及其应用
KR101720836B1 (ko) * 2014-08-05 2017-04-03 씨제이제일제당 (주) 피드백 저항성 아세토하이드록시산 신타아제 변이체 및 이를 이용한 l-발린의 생산방법
EP3229959B1 (de) 2014-12-09 2019-05-15 Life Technologies Corporation Hocheffiziente kleinvolumige nukleinsäuresynthese
US11021697B2 (en) 2017-07-11 2021-06-01 Cj Cheiljedang Corporation Acetohydroxy acid synthase variant, microorganism comprising the same, and method of producing L-branched-chain amino acid using the same
KR101996129B1 (ko) * 2017-07-11 2019-07-04 씨제이제일제당 (주) 아세토하이드록시산 신타아제 변이체, 이를 포함하는 미생물 또는 이를 이용하는 l-분지쇄 아미노산 생산 방법
WO2019118548A1 (en) * 2017-12-15 2019-06-20 Archer Daniels Midland Company Engineered strains of corynebacteria
AU2019243241B2 (en) * 2018-03-27 2022-12-01 Cj Cheiljedang Corporation A Novel Promoter And A Method For Producing L-Amino Acid Using The Same
EP3847270A1 (de) 2018-09-07 2021-07-14 Archer Daniels Midland Company Gentechnisch veränderte stämme von corynebakterium
KR102147381B1 (ko) * 2019-11-22 2020-08-24 씨제이제일제당 주식회사 아세토하이드록시산 신타제 신규 변이체 및 이를 포함하는 미생물

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US370057A (en) * 1887-09-20 Machine for packing cube sugar in boxes
US2979439A (en) * 1958-11-04 1961-04-11 Kyowa Hakko Kogyo Kk Method of producing l-lysine by fermentation
GB1118719A (en) * 1966-03-14 1968-07-03 Kyowa Hakko Kogyo Kk Process for producing l-lysine by fermentation
IT1045451B (it) * 1966-03-23 1980-05-10 Ajinomoto Kk Metodo per recuperare lisina da brodo di fermentazione
GB1180104A (en) * 1966-06-15 1970-02-04 Ajinomoto Kk Method of Producing L-Lysine.
JPS4828078B1 (de) * 1969-03-20 1973-08-29
JPS5544597B1 (de) * 1969-06-09 1980-11-13
JPS5610036B1 (de) * 1969-07-23 1981-03-05
US3825472A (en) * 1972-04-27 1974-07-23 Ajinomoto Kk Method of producing l-lysine by fermentation
JPS4981586A (de) 1972-12-12 1974-08-06
JPS579796B2 (de) * 1974-03-15 1982-02-23
JPS539394A (en) * 1976-07-09 1978-01-27 Kyowa Hakko Kogyo Co Ltd Preparation of l-lysine by fermentation
JPS56160997A (en) * 1980-05-16 1981-12-11 Ajinomoto Co Inc Preparation of l-lysine by fermenaition method
JPS58893A (ja) * 1981-06-25 1983-01-06 Ajinomoto Co Inc 発酵法によるｌ−イソロイシンの製造法
US5236831A (en) * 1981-12-29 1993-08-17 Kiowa Hakko Kogyo Co., Ltd. Amino acid synthesis in corynebacteria using E. coli genes
US4601983A (en) * 1983-06-15 1986-07-22 Ajinomoto Co., Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-threonine and L-isoleucine
EP0167132B1 (de) * 1984-06-29 1992-01-02 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Isoleucin durch Fermentation
DE3682709D1 (de) * 1985-05-13 1992-01-16 Toray Industries Verfahren zur herstellung von l-threonin durch fermentation.
DE3619111A1 (de) * 1986-06-06 1987-12-17 Degussa Verfahren zur fermentativen herstellung von l-isoleucin aus d,l-(alpha)-hydroxyburyrat
JPH0644872B2 (ja) * 1987-01-14 1994-06-15 三井東圧化学株式会社 発酵法によるｌ−スレオニンの製造方法
US5188948A (en) * 1987-04-16 1993-02-23 Ajinomoto Co., Inc. Process for producing L-valine by fermentation
US6261825B1 (en) * 1989-04-10 2001-07-17 Regents Of The University Of Minnesota Production of amino acids using auxotrophic mutants of methylotrophic bacillus
JP2876739B2 (ja) * 1990-08-03 1999-03-31 味の素株式会社 発酵法によるｌ―リジンの製造法
DE69116964T2 (de) * 1990-09-18 1996-10-02 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von L-Valin
DE69534592T2 (de) * 1994-03-04 2006-08-10 Ajinomoto Co., Inc. Verfahren für die herstellung von l-lysin
WO1996006180A1 (fr) * 1994-08-19 1996-02-29 Ajinomoto Co., Inc. Procede de production de l-lysine et d'acide l-glutamique par fermentation
JP3704737B2 (ja) * 1995-03-30 2005-10-12 味の素株式会社 Ｌ−ロイシンの製造方法
DE19547361A1 (de) * 1995-12-19 1997-06-26 Degussa Verfahren zur Herstellung von L-Aminosäuren durch Fermentation

Also Published As

Publication number Publication date
EP1200553B1 (de) 2009-07-15
EP1200553A1 (de) 2002-05-02
JP2010022374A (ja) 2010-02-04
US7635579B2 (en) 2009-12-22
JP2006280383A (ja) 2006-10-19
CA2380613A1 (en) 2001-02-08
MXPA02001174A (es) 2002-07-30
WO2001009286A1 (en) 2001-02-08
CN1367823A (zh) 2002-09-04
BR0012963A (pt) 2002-04-23
US20060154345A1 (en) 2006-07-13
KR100815041B1 (ko) 2008-03-18
US20080090272A1 (en) 2008-04-17
JP2003506030A (ja) 2003-02-18
US7323321B2 (en) 2008-01-29
JP5319489B2 (ja) 2013-10-16
NZ516893A (en) 2003-02-28
BR0012963B1 (pt) 2013-09-24
AU6617400A (en) 2001-02-19
AU779019B2 (en) 2005-01-06
KR20020033749A (ko) 2002-05-07
CA2380613C (en) 2014-03-25

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