DE60042090D1 - Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung - Google Patents

Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung

Info

Publication number
DE60042090D1
DE60042090D1 DE60042090T DE60042090T DE60042090D1 DE 60042090 D1 DE60042090 D1 DE 60042090D1 DE 60042090 T DE60042090 T DE 60042090T DE 60042090 T DE60042090 T DE 60042090T DE 60042090 D1 DE60042090 D1 DE 60042090D1
Authority
DE
Germany
Prior art keywords
catalyzed
hydrogen
metal
cofactor regeneration
enzymatic reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042090T
Other languages
English (en)
Inventor
Robert T Hembre
Paul S Wagenknecht
Jonathan M Penney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Chemical Co
Original Assignee
Eastman Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Chemical Co filed Critical Eastman Chemical Co
Application granted granted Critical
Publication of DE60042090D1 publication Critical patent/DE60042090D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60042090T 1999-03-11 2000-03-10 Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung Expired - Lifetime DE60042090D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12383399P 1999-03-11 1999-03-11

Publications (1)

Publication Number Publication Date
DE60042090D1 true DE60042090D1 (de) 2009-06-04

Family

ID=22411167

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60024615T Expired - Lifetime DE60024615T2 (de) 1999-03-11 2000-03-10 Phosphine Stabilisatoren für oxidoreduktase Enzyme
DE60042090T Expired - Lifetime DE60042090D1 (de) 1999-03-11 2000-03-10 Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60024615T Expired - Lifetime DE60024615T2 (de) 1999-03-11 2000-03-10 Phosphine Stabilisatoren für oxidoreduktase Enzyme

Country Status (8)

Country Link
US (2) US6599723B1 (de)
EP (2) EP1621613B1 (de)
JP (1) JP2002537831A (de)
CN (1) CN1352681A (de)
AU (1) AU3874900A (de)
DE (2) DE60024615T2 (de)
MX (1) MXPA01009132A (de)
WO (1) WO2000053731A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1621613B1 (de) * 1999-03-11 2009-04-22 Eastman Chemical Company Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung
JP2010517574A (ja) 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
DE102008030036B4 (de) 2008-06-18 2013-04-11 Technische Universität Dresden Verfahren für enzymkatalysierte Synthesen, zur Optimierung biotechnologischer und biosensorischer Prozesse und zur Regeneration von Cofaktoren
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
SI2510089T1 (sl) 2009-12-08 2015-12-31 Codexis, Inc. Sinteza prazolnih spojin
EP2566497B1 (de) 2010-05-04 2015-07-29 Codexis, Inc. Biokatalysatoren zur ezetimib-synthese
CN101972676B (zh) * 2010-09-17 2012-05-09 北京化工大学 一种手性氧化催化剂及其制备方法
EP2649187B1 (de) 2010-12-08 2017-11-22 Codexis, Inc. Biokatalysatoren und verfahren zur synthese von armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
GB201116971D0 (en) * 2011-10-03 2011-11-16 Isis Innovation Cofactor regeneration system
US9139819B2 (en) 2011-11-18 2015-09-22 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
US9193957B2 (en) 2012-05-11 2015-11-24 Codexis, Inc. Engineered imine reductases and methods for the reductive animation of ketone and amine compounds
CN104372039A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 双酶法制备瑞舒伐他汀侧链中间体的方法
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
WO2017123763A1 (en) 2016-01-13 2017-07-20 Rennovia Inc. Processes for the preparation of 2,5-furandicarboxylic acid and intermediates and derivatives thereof
EP3652161A1 (de) 2017-07-12 2020-05-20 Stora Enso Oyj Gereinigte 2,5-furandicarbonsäure-signalwegprodukte
EP3587393B1 (de) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Enzymatisches verfahren zur herstellung von droxidopa
CN113049712A (zh) * 2021-03-23 2021-06-29 上海创诺医药集团有限公司 一种测定环丙基甲基酮含量的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2588746A (en) * 1947-03-29 1952-03-11 Boyd R Mckinley Formation tester and pipe perforator
US3860484A (en) * 1972-09-28 1975-01-14 Xerox Corp Enzyme stabilization
FR2398046A1 (fr) * 1977-07-18 1979-02-16 Inst Francais Du Petrole Synthese enzymatique de la l-carnitine
US4352885A (en) 1980-05-09 1982-10-05 Wisconsin Alumni Research Foundation Preparation of a novel NADP linked alcohol-aldehyde/ketone oxidoreductase from thermophilic anaerobic bacteria for analytical and commercial use
DE3221339A1 (de) 1982-06-05 1983-12-08 Basf Ag, 6700 Ludwigshafen Verfahren zur elektrochemischen hydrierung von nicotinamidadenin-dinucleotid
US4652885A (en) * 1985-03-04 1987-03-24 The United States Of America As Represented By The Secretary Of The Army Dual mode antenna for millimeter wave and infrared radiation
DE3600274A1 (de) * 1986-01-08 1987-07-09 Basf Ag Verfahren zur selektiven regenerierung von mediatoren und katalysator dafuer
TW338768B (en) 1994-06-02 1998-08-21 Ciba Sc Holding Ag Oligometic HALS phosphites and HALS phosphonites as stabilizers
US5817467A (en) * 1995-11-16 1998-10-06 Kyowa Medex Co., Ltd. Method for quantitatively determining creatinine kinase and a reagent therefor
EP1621613B1 (de) * 1999-03-11 2009-04-22 Eastman Chemical Company Enzymatische Reduktion mit Hydrogen mittels metallkatalysierter Kofaktorregenerierung
US20040091985A1 (en) * 2002-02-22 2004-05-13 Metcalf William W. NAD phosphite oxidoreductase, a novel catalyst from bacteria for regeneration of NAD(P)H

Also Published As

Publication number Publication date
EP1181356B1 (de) 2005-12-07
EP1621613B1 (de) 2009-04-22
DE60024615T2 (de) 2006-07-06
MXPA01009132A (es) 2002-07-30
JP2002537831A (ja) 2002-11-12
EP1181356A2 (de) 2002-02-27
WO2000053731A2 (en) 2000-09-14
AU3874900A (en) 2000-09-28
CN1352681A (zh) 2002-06-05
US20030124696A1 (en) 2003-07-03
US7195889B2 (en) 2007-03-27
DE60024615D1 (de) 2006-01-12
US6599723B1 (en) 2003-07-29
WO2000053731A3 (en) 2001-11-29
EP1621613A1 (de) 2006-02-01

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