DE60039876D1 - Neuartiges verfahren zur herstellung bicyclischer amino-alkohole - Google Patents
Neuartiges verfahren zur herstellung bicyclischer amino-alkoholeInfo
- Publication number
- DE60039876D1 DE60039876D1 DE60039876T DE60039876T DE60039876D1 DE 60039876 D1 DE60039876 D1 DE 60039876D1 DE 60039876 T DE60039876 T DE 60039876T DE 60039876 T DE60039876 T DE 60039876T DE 60039876 D1 DE60039876 D1 DE 60039876D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- novel method
- amino alcohols
- bicyclic amino
- bicyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001414 amino alcohols Chemical class 0.000 title 1
- XZFDKWMYCUEKSS-UHFFFAOYSA-N 6,6-Dimethylbicyclo[3.1.1]heptan-2-one Chemical compound C1C2C(C)(C)C1CCC2=O XZFDKWMYCUEKSS-UHFFFAOYSA-N 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002923 oximes Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18867499 | 1999-07-02 | ||
| PCT/JP2000/004171 WO2001002334A1 (fr) | 1999-07-02 | 2000-06-26 | Nouveau procede de production d'amino-alcool bicyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60039876D1 true DE60039876D1 (de) | 2008-09-25 |
Family
ID=16227874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60039876T Expired - Fee Related DE60039876D1 (de) | 1999-07-02 | 2000-06-26 | Neuartiges verfahren zur herstellung bicyclischer amino-alkohole |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6723857B1 (de) |
| EP (2) | EP1808427A3 (de) |
| JP (1) | JP3730170B2 (de) |
| AT (1) | ATE404524T1 (de) |
| AU (1) | AU5430100A (de) |
| DE (1) | DE60039876D1 (de) |
| WO (1) | WO2001002334A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2898893A1 (fr) * | 2006-03-27 | 2007-09-28 | Ppg Sipsy Soc Par Actions Simp | Procede d'alkylation diastereoselective d'ether d'oxime du compose nopinone et nouveaux intermediaires pour la synthese de derives 2-amino-nopinone diastereospecifiques substitues sur le carbone 3 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06239917A (ja) | 1993-02-19 | 1994-08-30 | Mitsubishi Petrochem Co Ltd | α‐オレフィン重合用触媒成分およびそれを用いたα‐オレフィン重合体の製造法 |
| HU226458B1 (en) | 1996-12-13 | 2008-12-29 | Shionogi & Co | Benzothiophenecarboxamide derivatives, pharmaceutical compositions thereof and intermediates |
| RU2185380C1 (ru) * | 1998-03-31 | 2002-07-20 | Сионоги Энд Ко., Лтд. | Способ получения производных бензотиофенкарбоксамида и аминоспиртов (варианты) |
| HUP0101728A3 (en) | 1998-03-31 | 2002-04-29 | Shionogi & Co | 5-hydroxybenzo[b]thiophene-3-carboxylic acid and their derivatives and methods for producing them |
| ATE295183T1 (de) * | 1998-06-03 | 2005-05-15 | Shionogi & Co | Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten |
-
2000
- 2000-06-26 WO PCT/JP2000/004171 patent/WO2001002334A1/ja active IP Right Grant
- 2000-06-26 AU AU54301/00A patent/AU5430100A/en not_active Abandoned
- 2000-06-26 JP JP2001507777A patent/JP3730170B2/ja not_active Expired - Fee Related
- 2000-06-26 EP EP07008812A patent/EP1808427A3/de not_active Withdrawn
- 2000-06-26 DE DE60039876T patent/DE60039876D1/de not_active Expired - Fee Related
- 2000-06-26 EP EP00939160A patent/EP1193243B1/de not_active Expired - Lifetime
- 2000-06-26 AT AT00939160T patent/ATE404524T1/de not_active IP Right Cessation
- 2000-06-26 US US10/019,670 patent/US6723857B1/en not_active Expired - Fee Related
-
2004
- 2004-02-25 US US10/784,930 patent/US7214832B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6723857B1 (en) | 2004-04-20 |
| EP1193243B1 (de) | 2008-08-13 |
| EP1193243A1 (de) | 2002-04-03 |
| US20040171882A1 (en) | 2004-09-02 |
| JP3730170B2 (ja) | 2005-12-21 |
| ATE404524T1 (de) | 2008-08-15 |
| EP1808427A3 (de) | 2008-06-25 |
| WO2001002334A1 (fr) | 2001-01-11 |
| EP1193243A4 (de) | 2004-08-11 |
| EP1808427A2 (de) | 2007-07-18 |
| AU5430100A (en) | 2001-01-22 |
| US7214832B2 (en) | 2007-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |