DE60036456D1 - Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid - Google Patents

Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid

Info

Publication number
DE60036456D1
DE60036456D1 DE60036456T DE60036456T DE60036456D1 DE 60036456 D1 DE60036456 D1 DE 60036456D1 DE 60036456 T DE60036456 T DE 60036456T DE 60036456 T DE60036456 T DE 60036456T DE 60036456 D1 DE60036456 D1 DE 60036456D1
Authority
DE
Germany
Prior art keywords
present
polypeptide
patient
endotoxin
antimicrobial effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036456T
Other languages
English (en)
Other versions
DE60036456T2 (de
Inventor
David M Mann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agennix Inc
Original Assignee
Agennix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agennix Inc filed Critical Agennix Inc
Publication of DE60036456D1 publication Critical patent/DE60036456D1/de
Application granted granted Critical
Publication of DE60036456T2 publication Critical patent/DE60036456T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60036456T 1999-02-05 2000-01-27 Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid Expired - Lifetime DE60036456T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/245,527 US6399570B1 (en) 1999-02-05 1999-02-05 Antimicrobial/endotoxin neutralizing polypeptide
US245527 1999-02-05
PCT/IB2000/000271 WO2000049040A2 (en) 1999-02-05 2000-01-27 Antimicrobial/endotoxin neutralizing polypeptide

Publications (2)

Publication Number Publication Date
DE60036456D1 true DE60036456D1 (de) 2007-10-31
DE60036456T2 DE60036456T2 (de) 2008-06-19

Family

ID=22927039

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036456T Expired - Lifetime DE60036456T2 (de) 1999-02-05 2000-01-27 Antimikrobiell wirksames oder endotoxin neutralisierendes polypeptid

Country Status (12)

Country Link
US (2) US6399570B1 (de)
EP (1) EP1151009B1 (de)
JP (1) JP2002541066A (de)
CN (1) CN1362969A (de)
AT (1) ATE373679T1 (de)
AU (1) AU758150B2 (de)
CA (1) CA2362153C (de)
DE (1) DE60036456T2 (de)
DK (1) DK1151009T3 (de)
ES (1) ES2293892T3 (de)
MX (1) MXPA01007956A (de)
WO (1) WO2000049040A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US7060677B1 (en) 1999-11-11 2006-06-13 Am-Pharma B.V. Antimicrobial activity of the first cationic cluster of human lactoferrin
US20040082504A1 (en) * 2002-05-10 2004-04-29 Atul Varadhachary Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
US7238661B2 (en) * 2002-05-24 2007-07-03 Agennix, Inc. Oral lactoferrin in the treatment of respiratory disorders
DE60335997D1 (de) * 2002-09-16 2011-03-24 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
EP1581243A4 (de) * 2002-12-06 2008-01-02 Agennix Inc Orales lactoferrin für sepsisbehandlung
WO2004052305A2 (en) 2002-12-10 2004-06-24 Agennix Incorporated Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
US7034126B2 (en) 2003-05-14 2006-04-25 Agennix, Inc. Lactoferrin in the treatment of diabetes mellitus
CA2527904A1 (en) * 2003-06-06 2005-05-26 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
US7125963B2 (en) * 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
MX2008008548A (es) * 2005-12-30 2008-09-10 Evonik Roehm Gmbh Peptidos utiles como petidos penetradores de celulas.
EP2050461A1 (de) 2007-10-19 2009-04-22 PharmaSurgics in Sweden AB Peptide basierend auf der menschlichen Lactoferrinsequenz und ihre Verwendung
EP2060586A1 (de) * 2007-11-14 2009-05-20 PharmaSurgics in Sweden AB Neue synthetische Arginin-substituierte Peptide und ihre Verwendung
US20090209486A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090209487A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions of carbohydrates as dietary supplements
US20090208588A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown GERD carbohydrate compositions
US20090209488A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of exercise induced asthma
US20090209489A1 (en) * 2008-02-19 2009-08-20 Roger Wayne Brown Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system
CN101294188B (zh) * 2008-06-20 2011-06-15 江南大学 乳铁蛋白抗菌肽及其制备方法与它们的用途
JP5177901B2 (ja) * 2009-12-02 2013-04-10 株式会社明治 栄養組成物
CN101798337B (zh) * 2010-01-29 2013-04-24 中国人民解放军第三军医大学第一附属医院 内毒素中和肽突变体及其应用
EP2481751A1 (de) * 2011-01-26 2012-08-01 PharmaSurgics in Sweden AB Humanem Lactoferrin abgeleitete Peptide
JP5763024B2 (ja) * 2012-09-07 2015-08-12 株式会社明治 栄養組成物
WO2014124047A1 (en) * 2013-02-06 2014-08-14 Academia Sinica Antimicrobial peptides derived from hepatitis b virus core protein arginine-rich domain
CN106794218A (zh) * 2014-10-08 2017-05-31 学校法人庆应义塾 白细胞的细胞外诱捕网形成抑制剂
KR101996774B1 (ko) * 2014-11-03 2019-07-04 메르크 파텐트 게엠베하 생체분자를 정제하기 위한 가용성 인테인 융합 단백질 및 방법
BR112018074478A2 (pt) * 2016-05-27 2019-03-19 Academia Sinica peptídeo antimicrobiano modificado derivado de um domínio rico em arginina
CN105999236A (zh) * 2016-07-06 2016-10-12 方雅悯 一种治疗牛***炎的药剂及其应用

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US4977137B1 (en) 1987-06-03 1994-06-28 Baylor College Medicine Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract
US6020015A (en) * 1988-09-22 2000-02-01 Gaull; Gerald E. Infant formula compositions and nutrition containing genetically engineered human milk proteins
JP2805490B2 (ja) * 1989-02-07 1998-09-30 雪印乳業株式会社 細菌毒素中和剤
US5141743A (en) * 1989-04-27 1992-08-25 University Technologies International, Inc. Method for isolating and purifying transferrin and lactoferrin receptor proteins and vaccines containing the same
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5766939A (en) 1989-05-05 1998-06-16 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US6100054A (en) 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
US5849881A (en) * 1989-05-05 1998-12-15 Baylor College Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
US5198419A (en) * 1989-12-08 1993-03-30 Immuno Japan Inc. Formulated medicines for enhancing the efficacy of beta-lactam antibiotics in prophylaxis and treatment against infectious disease due to pathogenic bacteria
EP0438750B1 (de) 1990-01-23 1993-10-27 Morinaga Milk Industry Co., Ltd. Laktoferrinhydrolysat zur Verwendung als antibakterielles Mittel
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US5240909B1 (en) * 1990-03-14 1998-01-20 Dietrich Nitsche Use of lactoferrin for treatment of toxic effects of endotoxins
DE4008033A1 (de) 1990-03-14 1991-09-19 Nitsche Dietrich Verwendung von lactoferrin zur bekaempfung der toxischen wirkung des endotoxins
JP2818056B2 (ja) 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤
EP0579830B1 (de) * 1990-11-13 1997-02-05 Santen Pharmaceutical Co., Ltd. Therapeutische agens bei hornhautverletzungen
JP3110078B2 (ja) 1991-06-21 2000-11-20 森永乳業株式会社 高純度抗菌性ペプチドの大量製造法
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DK0559425T3 (da) * 1992-03-02 1999-08-30 Japan Immuno Inc Anvendelse af proteiner tilhørende transferrin/lactoferrinfamilien til stimulering af immunsystemet
ZA932568B (en) 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin
JP3100005B2 (ja) * 1992-07-28 2000-10-16 雪印乳業株式会社 ヒト免疫不全ウィルス感染・増殖抑制剤
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US20040082504A1 (en) * 2002-05-10 2004-04-29 Atul Varadhachary Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
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SE526038C2 (sv) * 2002-07-08 2005-06-21 Gambro Lundia Ab Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav
DE60335997D1 (de) * 2002-09-16 2011-03-24 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
EP1581243A4 (de) * 2002-12-06 2008-01-02 Agennix Inc Orales lactoferrin für sepsisbehandlung
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US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof

Also Published As

Publication number Publication date
US6399570B1 (en) 2002-06-04
EP1151009A2 (de) 2001-11-07
DK1151009T3 (da) 2008-01-28
US20030105006A1 (en) 2003-06-05
AU2822600A (en) 2000-09-04
WO2000049040A3 (en) 2000-12-14
CA2362153C (en) 2009-11-24
US7244706B2 (en) 2007-07-17
JP2002541066A (ja) 2002-12-03
CN1362969A (zh) 2002-08-07
ATE373679T1 (de) 2007-10-15
CA2362153A1 (en) 2000-08-24
ES2293892T3 (es) 2008-04-01
WO2000049040A2 (en) 2000-08-24
DE60036456T2 (de) 2008-06-19
MXPA01007956A (es) 2004-08-19
EP1151009B1 (de) 2007-09-19
AU758150B2 (en) 2003-03-13

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