DE60033402D1 - In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern - Google Patents

In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern

Info

Publication number
DE60033402D1
DE60033402D1 DE60033402T DE60033402T DE60033402D1 DE 60033402 D1 DE60033402 D1 DE 60033402D1 DE 60033402 T DE60033402 T DE 60033402T DE 60033402 T DE60033402 T DE 60033402T DE 60033402 D1 DE60033402 D1 DE 60033402D1
Authority
DE
Germany
Prior art keywords
library
fusion protein
polypeptides
solid phase
phase carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60033402T
Other languages
English (en)
Other versions
DE60033402T2 (de
Inventor
Per-Ake Nygren
Mathias Uhlen
Olof Nord
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affibody AB
Original Assignee
Affibody AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody AB filed Critical Affibody AB
Application granted granted Critical
Publication of DE60033402D1 publication Critical patent/DE60033402D1/de
Publication of DE60033402T2 publication Critical patent/DE60033402T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60033402T 1999-07-20 2000-07-20 In-vitro-Selektion und wahlweise Identifizierung von Polypeptiden unter Verwendung von festen Trägern Expired - Lifetime DE60033402T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9917027 1999-07-20
GBGB9917027.6A GB9917027D0 (en) 1999-07-20 1999-07-20 In vitro selection and optional identification of polypeptides using solid support carriers
PCT/GB2000/002809 WO2001005808A2 (en) 1999-07-20 2000-07-20 In vitro selection and optional identification of polypeptides using solid support carriers

Publications (2)

Publication Number Publication Date
DE60033402D1 true DE60033402D1 (de) 2007-03-29
DE60033402T2 DE60033402T2 (de) 2007-11-29

Family

ID=10857605

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033402T Expired - Lifetime DE60033402T2 (de) 1999-07-20 2000-07-20 In-vitro-Selektion und wahlweise Identifizierung von Polypeptiden unter Verwendung von festen Trägern

Country Status (13)

Country Link
US (2) US6955877B1 (de)
EP (2) EP1200577B1 (de)
JP (1) JP2003505041A (de)
AT (1) ATE353963T1 (de)
AU (1) AU761985B2 (de)
CA (1) CA2379143A1 (de)
DE (1) DE60033402T2 (de)
DK (1) DK1200577T3 (de)
ES (1) ES2279761T3 (de)
GB (1) GB9917027D0 (de)
NO (1) NO20020276L (de)
WO (1) WO2001005808A2 (de)
ZA (1) ZA200200194B (de)

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DE10123644A1 (de) * 2001-05-04 2002-11-07 Lifebits Ag Verfahren zum Aufbringen von Proteinen auf einen Träger
US7731697B2 (en) * 2003-04-12 2010-06-08 Incumed Llc, A Nevada Limited Liability Co. Apparatus and method for percutaneous catheter implantation and replacement
US20050260653A1 (en) * 2004-04-14 2005-11-24 Joshua Labaer Nucleic-acid programmable protein arrays
US8796441B2 (en) * 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
US8932879B2 (en) * 2007-11-06 2015-01-13 Ambergen, Inc. Methods and compounds for phototransfer
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
EP2090890A1 (de) 2008-02-15 2009-08-19 Atlas Antibodies AB RBM3 als Marker für die Brustkrebsprognose
US20110144198A1 (en) 2008-05-16 2011-06-16 Atlas Antibodies Ab Breast cancer prognostics
WO2010086400A1 (en) 2009-01-30 2010-08-05 Atlas Antibodies Ab Combination treatment of breast cancer
WO2009146755A1 (en) * 2008-06-05 2009-12-10 Affibody Ab Polypeptide
EP2331140B1 (de) 2008-08-11 2018-07-04 Nektar Therapeutics Mehrarmige polymer-alkanoat-konjugate
EP2161577A1 (de) 2008-09-01 2010-03-10 Atlas Antibodies AB ANLN-Protein
EP2172477A1 (de) 2008-10-06 2010-04-07 Atlas Antibodies AB Neue Epitope und Verwendungen davon
EP2396657B1 (de) 2009-02-16 2013-11-13 Atlas Antibodies AB Rbm3 als marker für die prognose von malignem melanom
EP2524928A1 (de) 2011-05-18 2012-11-21 Atlas Antibodies AB RBM3 in Blasenkrebs
EP2293070A1 (de) 2009-08-13 2011-03-09 Atlas Antibodies AB Mittel und Verfahren zur Prognose von Eierstockkrebs
EP2241889A1 (de) 2009-04-16 2010-10-20 Atlas Antibodies AB RBM3-Protein bei Kolorektalkrebsprognosen
EP2259059A1 (de) 2009-05-29 2010-12-08 Atlas Antibodies AB Mittel und Verfahren zur Prognose von Eierstockkrebs
EP2315028A1 (de) 2009-10-26 2011-04-27 Atlas Antibodies AB PODXL-Protein bei Kolorektalkrebs
EP2390665A1 (de) 2010-05-27 2011-11-30 Atlas Antibodies AB Prostatakrebs-Biomarker
WO2012055854A1 (en) 2010-10-27 2012-05-03 Spiber Technologies Ab Spider silk fusion protein structures for binding to an organic target
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012110824A1 (en) 2011-02-18 2012-08-23 Astrazeneca Ab Binding agents with specificity for a nucleic acid modification
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
EP2544007A1 (de) 2011-07-07 2013-01-09 Atlas Antibodies AB Biomarker für Nierenfunktionsstörung
EP2573566A1 (de) 2011-09-20 2013-03-27 Atlas Antibodies AB RBM3 bei Prostatakrebsprognosen
EP2602622A1 (de) 2011-12-07 2013-06-12 Atlas Antibodies AB Vorhersage der Reaktion auf eine Platinbasierte Therapie
WO2013098676A1 (en) 2011-12-30 2013-07-04 Grifols, S.A. Method for purifying factor viii
WO2013116698A2 (en) * 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
AU2013255815B2 (en) 2012-05-02 2018-03-29 Spiber Technologies Ab Spider silk fusion protein structures without repetitive fragment for binding to an organic target
EP2844361B1 (de) 2012-05-02 2020-03-25 Spiber Technologies AB Spinnenseidenfusionsproteinstrukturen mit immunglobulinfragmenten als affinitätsliganden
EP2746768A1 (de) 2012-12-20 2014-06-25 Atlas Antibodies AB PODXL bei Blasenkrebs
EP2787350A1 (de) 2013-04-05 2014-10-08 Atlas Antibodies AB ASRGL1 bei Gebärmutterschleimhautkrebs
EP3023791A1 (de) 2014-11-21 2016-05-25 Atlas Antibodies AB Vorhersage des Ansprechens auf Behandlung mit Gemcitabin
PT3283508T (pt) 2015-04-17 2021-06-21 Alpine Immune Sciences Inc Proteínas imuno modulatórias com afinidades afináveis

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US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
EP0985142A4 (de) * 1997-05-23 2006-09-13 Lynx Therapeutics Inc System und gerät zur sequentiellen behandlung von analyten
DE69818458T3 (de) 1997-05-28 2009-12-17 Crescendo Biologics Ltd., Babraham Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
WO1998056954A1 (en) * 1997-06-13 1998-12-17 Affymetrix, Inc. Method to detect gene polymorphisms and monitor allelic expression employing a probe array
EP1801214B1 (de) 1997-07-07 2010-11-10 Medical Research Council In-vitro-Sortierverfahren
DK1032660T3 (da) * 1997-11-17 2010-01-18 Micromet Ag Fremgangsmåde til identivicering af bindingsstedsdominans som bevarer evnen til at binde til en epitop
US6265163B1 (en) * 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes

Also Published As

Publication number Publication date
ES2279761T3 (es) 2007-09-01
ATE353963T1 (de) 2007-03-15
GB9917027D0 (en) 1999-09-22
WO2001005808A2 (en) 2001-01-25
AU6005300A (en) 2001-02-05
JP2003505041A (ja) 2003-02-12
DE60033402T2 (de) 2007-11-29
NO20020276L (no) 2002-03-15
CA2379143A1 (en) 2001-01-25
EP1200577A2 (de) 2002-05-02
AU761985B2 (en) 2003-06-12
EP1826270A1 (de) 2007-08-29
DK1200577T3 (da) 2007-06-11
US6955877B1 (en) 2005-10-18
EP1200577B1 (de) 2007-02-14
US20060035265A1 (en) 2006-02-16
ZA200200194B (en) 2003-06-25
WO2001005808A3 (en) 2001-08-02
NO20020276D0 (no) 2002-01-18

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: NYGREN, PER-AKE, EKEROE, SE

Inventor name: UHLEN, MATHIAS, TAEBY, SE

Inventor name: NORD, OLOF, BROMMA, SE

8364 No opposition during term of opposition