DE60027648D1 - Sulfonamide enthaltende indolderivate - Google Patents

Sulfonamide enthaltende indolderivate

Info

Publication number: DE60027648D1
Authority: DE; Germany
Prior art keywords: hydrogen; ring; represents hydrogen; cyanophenyl; group
Prior art date: 1999-02-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60027648T

Other languages

English (en)

Other versions

DE60027648T2 (de

Inventor

Toru Haneda

Akihiko Tsuruoka

Junichi Kamata

Tadashi Okabe

Keiko Takahashi

Kazumasa Nara

Shinichi Hamaoka

Norihiro Ueda

Takashi Owa

Toshiaki Wakabayashi

Yasuhiro Funahashi

Taro Semba

Naoko Hata

Yuji Yamamoto

Yoichi Ozawa

Naoko Tsukahara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eisai R&D Management Co Ltd

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-26

Filing date

2000-02-24

Publication date

2006-06-08

2000-02-24 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2006-06-08 Publication of DE60027648D1 publication Critical patent/DE60027648D1/de

2007-04-05 Application granted granted Critical

2007-04-05 Publication of DE60027648T2 publication Critical patent/DE60027648T2/de

2020-02-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

DE60027648T 1999-02-26 2000-02-24 Sulfonamide enthaltende indolderivate Expired - Lifetime DE60027648T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP11049870A JP2000247949A (ja)	1999-02-26	1999-02-26	スルホンアミド含有インドール化合物
JP4987099		1999-02-26
PCT/JP2000/001071 WO2000050395A1 (fr)	1999-02-26	2000-02-24	Composes indoles contenant un sulfonamide

Publications (2)

Publication Number	Publication Date
DE60027648D1 true DE60027648D1 (de)	2006-06-08
DE60027648T2 DE60027648T2 (de)	2007-04-05

Family

ID=12843091

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60027648T Expired - Lifetime DE60027648T2 (de)	1999-02-26	2000-02-24	Sulfonamide enthaltende indolderivate

Country Status (17)

Country	Link
US (3)	US6469043B1 (de)
EP (1)	EP1074542B1 (de)
JP (3)	JP2000247949A (de)
KR (1)	KR100627611B1 (de)
CN (1)	CN1132814C (de)
AT (1)	ATE325094T1 (de)
AU (1)	AU766936B2 (de)
CA (1)	CA2327253C (de)
DE (1)	DE60027648T2 (de)
DK (1)	DK1074542T3 (de)
ES (1)	ES2259997T3 (de)
HU (1)	HU228787B1 (de)
NO (1)	NO317299B1 (de)
NZ (1)	NZ507464A (de)
PT (1)	PT1074542E (de)
RU (1)	RU2208607C2 (de)
WO (1)	WO2000050395A1 (de)

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ATE464892T1 (de) *	2000-02-03	2010-05-15	Eisai R&D Man Co Ltd	Inhibitoren der integrinexpression
WO2002017897A2 (en) *	2000-08-30	2002-03-07	Primecyte, Inc.	Methods for treating tumors using sulfonyl compounds
TWI283575B (en) *	2000-10-31	2007-07-11	Eisai Co Ltd	Medicinal compositions for concomitant use as anticancer agent
US7122318B2 (en) *	2001-02-21	2006-10-17	Eisai Co., Ltd.	Method for testing effect of angiogenesis inhibitor via integrin expression inhibition
EP1433479B8 (de) *	2001-09-05	2008-01-23	Eisai R&D Management Co., Ltd.	Mittel zur anregung des appetits und mittel zur behandlung von anorexie
CN1551766A (zh) *	2001-09-05	2004-12-01	��ʽ��	淋巴细胞活化抑制剂和自身免疫性疾病治疗剂
AU2003211594A1 (en) *	2002-03-05	2003-09-16	Eisai Co., Ltd.	Antitumor agent comprising combination of sulfonamide-containing heterocyclic compound with angiogenesis inhibitor
EP1608626A1 (de) *	2003-03-28	2005-12-28	Cornell Research Foundation, Inc.	Migrastatin-analoga enthaltende zusammensetzungen und deren verwendung
WO2004091664A1 (ja) *	2003-04-18	2004-10-28	Eisai Co., Ltd.	細胞質リンゴ酸脱水素酵素阻害剤
WO2005026119A1 (ja) *	2003-09-10	2005-03-24	Eisai Co., Ltd.	スルホンアミド含有インドール化合物の製造方法
NZ546111A (en) *	2003-09-10	2008-11-28	Eisai R&D Man Co Ltd	Crystal of sulfonamide-containing indole compound and process for producing the same
ES2382942T3 (es) *	2003-11-13	2012-06-14	Sutter West Bay Hospitals	Terapia anti-pecam para la supresión de la metástasis
JP5149001B2 (ja) *	2004-05-25	2013-02-20	スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ	癌の処置におけるマイグラスタチンアナログ
EP1797877A4 (de)	2004-09-13	2010-12-15	Eisai Co Ltd	Gemeinsame verwendung einer verbindung auf sulfonamid-basis mit einem angiogenese-hemmer
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006034478A2 (en) *	2004-09-23	2006-03-30	Sloan-Kettering Institute For Cancer Research	Isomigrastatin analogs in the treatment of cancer
WO2006090930A1 (ja)	2005-02-28	2006-08-31	Eisai R & D Management Co., Ltd.	スルホンアミド化合物の新規併用
EP2308839B1 (de) *	2005-04-20	2017-03-01	Takeda Pharmaceutical Company Limited	Kondensierte heterozyklische verbindungen
CN101360422B (zh) *	2005-11-23	2013-10-23	得克萨斯大学体系董事会	致癌Ras特异性细胞毒化合物及其使用方法
US7625896B2 (en) *	2005-11-25	2009-12-01	Hoffman-La Roche Inc.	Pyridylsulfonamide derivatives
WO2007086605A1 (ja) *	2006-01-27	2007-08-02	Eisai R & D Management Co., Ltd.	スルホンアミド化合物の効果を予測する方法
US20100291592A1 (en)	2006-04-20	2010-11-18	Taro Semba	Novel marker for sensitivity against sulfonamide compound
DE102007012284A1 (de) *	2007-03-16	2008-09-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035334A1 (de)	2007-07-27	2009-01-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007035333A1 (de)	2007-07-27	2009-01-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
DE102007042154A1 (de)	2007-09-05	2009-03-12	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
US20090142832A1 (en) *	2007-11-29	2009-06-04	James Dalton	Indoles, Derivatives, and Analogs Thereof and Uses Therefor
JP2012136435A (ja) *	2009-03-30	2012-07-19	Eisai R & D Management Co Ltd	腫瘍組織の感受性を検査する方法
CN104334527B (zh)	2012-02-22	2017-05-24	桑福德-伯纳姆医学研究院	磺酰胺化合物及作为tnap抑制剂的用途
CN104098498A (zh) *	2014-07-30	2014-10-15	天津市斯芬克司药物研发有限公司	一种吲唑类化合物及其制备方法
RU2748835C1 (ru) *	2017-11-27	2021-05-31	Совет Научных И Прикладных Исследований	Индол(сульфонил)-n-гидроксибензамидные производные в качестве селективных ингибиторов hdac
WO2019147783A1 (en) *	2018-01-25	2019-08-01	Dana-Farber Cancer Institute, Inc.	Sulfonamide derivatives for protein degradation
US20220162193A1 (en) *	2019-04-10	2022-05-26	Peloton Therapeutics, Inc.	Pyrazolesulfonamides as antitumor agents
US20240092770A1 (en) *	2022-08-15	2024-03-21	Recursion Pharmaceuticals, Inc.	Heterocycle RMB39 Modulators

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Publication number	Priority date	Publication date	Assignee	Title
GB9115160D0 (en) *	1991-07-12	1991-08-28	Erba Carlo Spa	Methylen-oxindole derivatives and process for their preparation
JP3545461B2 (ja) *	1993-09-10	2004-07-21	エーザイ株式会社	二環式ヘテロ環含有スルホンアミド誘導体
KR0174752B1 (ko) *	1993-09-10	1999-02-01	나이토 하루오	이환식 헤테로환 함유 술폰아미드 유도체 및 그 제조방법
JP3690831B2 (ja)	1995-02-27	2005-08-31	エーザイ株式会社	インドール含有スルホンアミド誘導体
JP4130700B2 (ja) *	1996-02-26	2008-08-06	エーザイ・アール・アンド・ディー・マネジメント株式会社	抗腫瘍剤含有組成物
JP3868534B2 (ja)	1996-05-24	2007-01-17	エーザイ・アール・アンド・ディー・マネジメント株式会社	スルホンアミド誘導体の製造法および中間体
ATE464892T1 (de)	2000-02-03	2010-05-15	Eisai R&D Man Co Ltd	Inhibitoren der integrinexpression

1999
- 1999-02-26 JP JP11049870A patent/JP2000247949A/ja active Pending
2000
- 2000-02-24 EP EP00905321A patent/EP1074542B1/de not_active Expired - Lifetime
- 2000-02-24 HU HU0101434A patent/HU228787B1/hu not_active IP Right Cessation
- 2000-02-24 NZ NZ507464A patent/NZ507464A/en not_active IP Right Cessation
- 2000-02-24 WO PCT/JP2000/001071 patent/WO2000050395A1/ja active IP Right Grant
- 2000-02-24 DE DE60027648T patent/DE60027648T2/de not_active Expired - Lifetime
- 2000-02-24 CA CA002327253A patent/CA2327253C/en not_active Expired - Fee Related
- 2000-02-24 JP JP2000600978A patent/JP3866041B2/ja not_active Expired - Fee Related
- 2000-02-24 AU AU26916/00A patent/AU766936B2/en not_active Ceased
- 2000-02-24 PT PT00905321T patent/PT1074542E/pt unknown
- 2000-02-24 KR KR1020007011026A patent/KR100627611B1/ko not_active IP Right Cessation
- 2000-02-24 AT AT00905321T patent/ATE325094T1/de active
- 2000-02-24 DK DK00905321T patent/DK1074542T3/da active
- 2000-02-24 RU RU2000129508/04A patent/RU2208607C2/ru not_active IP Right Cessation
- 2000-02-24 US US09/647,215 patent/US6469043B1/en not_active Expired - Lifetime
- 2000-02-24 ES ES00905321T patent/ES2259997T3/es not_active Expired - Lifetime
- 2000-02-24 CN CN008002290A patent/CN1132814C/zh not_active Expired - Fee Related
- 2000-10-24 NO NO20005357A patent/NO317299B1/no not_active IP Right Cessation
2002
- 2002-03-18 US US10/098,421 patent/US6638964B2/en not_active Expired - Lifetime
- 2002-03-18 US US10/098,420 patent/US6673787B2/en not_active Expired - Lifetime
2010
- 2010-04-02 JP JP2010085696A patent/JP2010180229A/ja active Pending

Also Published As

Publication number	Publication date
EP1074542A1 (de)	2001-02-07
US6469043B1 (en)	2002-10-22
EP1074542B1 (de)	2006-05-03
KR20010042434A (ko)	2001-05-25
NZ507464A (en)	2003-10-31
JP2000247949A (ja)	2000-09-12
PT1074542E (pt)	2006-07-31
NO20005357L (no)	2000-12-22
CN1294579A (zh)	2001-05-09
EP1074542A4 (de)	2002-02-06
AU2691600A (en)	2000-09-14
RU2208607C2 (ru)	2003-07-20
US6638964B2 (en)	2003-10-28
JP2010180229A (ja)	2010-08-19
NO317299B1 (no)	2004-10-04
DK1074542T3 (da)	2006-08-14
WO2000050395A1 (fr)	2000-08-31
JP3866041B2 (ja)	2007-01-10
ATE325094T1 (de)	2006-06-15
CN1132814C (zh)	2003-12-31
DE60027648T2 (de)	2007-04-05
NO20005357D0 (no)	2000-10-24
KR100627611B1 (ko)	2006-09-25
US20020128480A1 (en)	2002-09-12
CA2327253C (en)	2007-10-16
HUP0101434A2 (hu)	2001-09-28
HU228787B1 (en)	2013-05-28
US20020128483A1 (en)	2002-09-12
US6673787B2 (en)	2004-01-06
ES2259997T3 (es)	2006-11-01
AU766936B2 (en)	2003-10-23
CA2327253A1 (en)	2000-08-31
HUP0101434A3 (en)	2001-10-29

Legal Events

Date	Code	Title	Description
2007-05-24	8364	No opposition during term of opposition
2008-09-11	8327	Change in the person/name/address of the patent owner	Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP

Publication	Publication Date	Title
DE60027648D1 (de)	2006-06-08	Sulfonamide enthaltende indolderivate
NZ514873A (en)	2004-05-28	4,5,6,7-tetrahydroindazole derivatives as antitumor agents
DE68924681T2 (de)	1996-04-04	Heterocyclische Biphosphonsäurederivate.
DK0928788T3 (da)	2003-03-24	Imidazolidin-4-on-derivater, der er nyttige som anticancer-midler
ATE289602T1 (de)	2005-03-15	Quinolin-2-on-derivate verwendbar als antikrebsmittel
EA200401056A1 (ru)	2005-04-28	Комбинация, содержащая производные тропана, полезные в терапии
HUP0400250A2 (hu)	2004-08-30	5-HT6 és/vagy 5-HT7 szerotonin receptorok ligandumaként alkalmazott 5-halogén-triptamin-származékok, előállításuk és alkalmazásuk gyógyszerkészítmények előállítására
DE69609325T2 (de)	2000-11-23	Derivate des radicicols
CA2134077A1 (en)	1993-11-11	4-imidomethyl-1-[2'phenyl-2'oxoethyl-]piperidines as serotonin 5ht2-antagonists, their preparation and use in therapy
ATE233242T1 (de)	2003-03-15	Chinoline und chinazoline verbindungen und ihre therapeutische anwendung
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
NO961797L (no)	1996-11-06	Anvendelse av benzopyranderivater for fremstilling av farmasöytiske sammensetninger beregnet for behandling av patologier forbundet med den Na+-uavhengige C1-HCO3-utbytter
TR200002831A2 (tr)	2001-04-20	Kinolin-4-İl türevleri I
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
MEP12408A (en)	2010-06-10	Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors
HUP0002715A2 (hu)	2001-06-28	Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására
HUP9902270A1 (hu)	2000-06-28	Analgetikus hatású akridinszármazékok, előállításuk és alkalmazásuk
EP0254527A3 (en)	1989-11-23	New tetracyclic indole derivatives
ATE79625T1 (de)	1992-09-15	Substituierte 1,3,4,9-tetrahydropyrano(3,4b>indol-1-essigs\|uren.